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The map label for this gene is mlrA

Identifier: 218695738

GI number: 218695738

Start: 2430366

End: 2431097

Strand: Direct

Name: mlrA

Synonym: EC55989_2376

Alternate gene names: 218695738

Gene position: 2430366-2431097 (Clockwise)

Preceding gene: 218695734

Following gene: 218695739

Centisome position: 47.15

GC content: 53.14

Gene sequence:

>732_bases
ATGGCGCTTTACACAATTGGTGAAGTGGCGTTGCTTTGTGATATTAACCCTGTCACGTTACGCGCGTGGCAGAGGCGTTA
CGGGTTGCTGAAACCGCAACGGACAGACGGCGGTCATCGACTGTTCAACGATGCCGATATTGACCGTATCCGCGAGATCA
AACGCTGGATCGACAACGGCGTGCAGGTCAGCAAAGTTAAAATGCTGCTCAGTAATGAAAATGTTGATGTGCAGAACGGC
TGGCGCGATCAGCAAGAAACATTACTGACCTACCTGCAAAGCGGCAATCTGCATAGCCTGCGAACGTGGATCAAAGAGCG
CGGTCAGGATTACCCCGCCCAGACACTCACCACACATCTGTTTATTCCTCTGCGCCGACGGCTTCAGTGCCAACAACCGA
CTCTCCAGGCGCTGCTGGCGATCCTCGACGGCGTACTGATCAACTACATCGCCATTTGTCTGGCTTCGGCACGTAAAAAA
CAGGGTAAAGATGCGCTGGTGGTTGGCTGGAATATTCAGGATACCACCCGTCTGTGGCTGGAGGGCTGGATTGCCAGTCA
ACAAGGATGGCGCATTGATGTCCTCGCCCACTCGCTCAATCAACTACGCCCTGAACTATTCGAAGGCCGTACATTGCTGG
TGTGGTGCGGTGAAAATCGAACCTCCGCCCAACAGCAGCAACTCACCAGTTGGCAAGAACAAGGCCATGATATTTTCCCA
CTCGGCATTTAA

Upstream 100 bases:

>100_bases
ATAAAATCACCCTATAGATGCACAAAAAACGGGCAAAACTACCTGGTTCGCAAAACTGCGTCTAAAGTTAAACCGGGACC
TCGCGAGCAAGGGTGAGACG

Downstream 100 bases:

>100_bases
TGATTCGTTAACAAATGCGCTTTACTGTACAATCCTTTCGTTAACATAAGGAGTGCAATATGCGCATAGCTAAAATTGGG
GTCATCGCCCTGTTCCTGTT

Product: DNA-binding transcriptional regulator

Products: NA

Alternate protein names: MerR-like regulator A

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNENVDVQNG
WRDQQETLLTYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKK
QGKDALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENRTSAQQQQLTSWQEQGHDIFP
LGI

Sequences:

>Translated_243_residues
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNENVDVQNG
WRDQQETLLTYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKK
QGKDALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENRTSAQQQQLTSWQEQGHDIFP
LGI
>Mature_242_residues
ALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNGVQVSKVKMLLSNENVDVQNGW
RDQQETLLTYLQSGNLHSLRTWIKERGQDYPAQTLTTHLFIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKKQ
GKDALVVGWNIQDTTRLWLEGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENRTSAQQQQLTSWQEQGHDIFPL
GI

Specific function: Transcriptional activator of the csg genes required for production of the curli (AgF)

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1788448, Length=243, Percent_Identity=100, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI1787409, Length=239, Percent_Identity=48.5355648535565, Blast_Score=242, Evalue=2e-65,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): MLRA_ECOLI (P33358)

Other databases:

- EMBL:   AF288173
- EMBL:   AF288174
- EMBL:   U00007
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   F64980
- RefSeq:   AP_002723.1
- RefSeq:   NP_416631.1
- ProteinModelPortal:   P33358
- SMR:   P33358
- STRING:   P33358
- EnsemblBacteria:   EBESCT00000000508
- EnsemblBacteria:   EBESCT00000016764
- GeneID:   949029
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW2115
- KEGG:   eco:b2127
- EchoBASE:   EB1946
- EcoGene:   EG12008
- eggNOG:   COG0789
- GeneTree:   EBGT00050000010907
- HOGENOM:   HBG417247
- OMA:   WLEAWIA
- ProtClustDB:   PRK15043
- BioCyc:   EcoCyc:EG12008-MONOMER
- Genevestigator:   P33358
- InterPro:   IPR009061
- InterPro:   IPR000551
- SMART:   SM00422

Pfam domain/function: PF00376 MerR; SSF46955 Putativ_DNA_bind

EC number: NA

Molecular weight: Translated: 28047; Mature: 27915

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00552 HTH_MERR_1; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNG
CCEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
VQVSKVKMLLSNENVDVQNGWRDQQETLLTYLQSGNLHSLRTWIKERGQDYPAQTLTTHL
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHH
FIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKKQGKDALVVGWNIQDTTRLWL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
EGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENRTSAQQQQLTSWQEQGHDIFP
HHHHCCCCCCCHHHHHHHHHHHCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEC
LGI
CCC
>Mature Secondary Structure 
ALYTIGEVALLCDINPVTLRAWQRRYGLLKPQRTDGGHRLFNDADIDRIREIKRWIDNG
CEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
VQVSKVKMLLSNENVDVQNGWRDQQETLLTYLQSGNLHSLRTWIKERGQDYPAQTLTTHL
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHH
FIPLRRRLQCQQPTLQALLAILDGVLINYIAICLASARKKQGKDALVVGWNIQDTTRLWL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
EGWIASQQGWRIDVLAHSLNQLRPELFEGRTLLVWCGENRTSAQQQQLTSWQEQGHDIFP
HHHHCCCCCCCHHHHHHHHHHHCHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEC
LGI
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11489123; 9278503