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The map label for this gene is zwf

Identifier: 218695418

GI number: 218695418

Start: 2086022

End: 2087497

Strand: Reverse

Name: zwf

Synonym: EC55989_2030

Alternate gene names: 218695418

Gene position: 2087497-2086022 (Counterclockwise)

Preceding gene: 218695421

Following gene: 218695417

Centisome position: 40.5

GC content: 51.56

Gene sequence:

>1476_bases
ATGGCGGTAACGCAAACAGCCCAGGCCTGTGACCTGGTCATTTTCGGCGCGAAAGGCGACCTTGCGCGTCGTAAATTGCT
GCCTTCCCTGTATCAACTGGAAAAAGCCGGTCAGCTCAACCCGGACACCCGGATTATCGGCGTAGGGCGTGCTGACTGGG
ATAAAGCGGCATATACCAAAGTTGTCCGCGAGGCGCTCGAAACTTTCATGAAAGAAACCATTGATGAAGGTTTATGGGAC
ACCCTGAGTGCACGTCTGGATTTTTGTAATCTCGATGTCAATGACACTGCTGCATTCAACCGTCTCGGCGCGATGCTGGA
TCAAAAAAATCGTATCACCATTAACTACTTTGCCATGCCGCCCAGCACTTTTGGCGCAATTTGCAAAGGGCTTGGCGAGG
CAAAACTGAATGCTAAACCGGCACGCGTAGTCATGGAGAAACCGCTGGGGACGTCGCTGGCGACCTCGCAGGAAATCAAT
GATCAGGTTGGCGAATACTTCGAGGAGTGCCAGGTTTACCGTATCGACCACTATCTTGGTAAAGAAACGGTGCTGAACCT
GTTGGCGCTGCGTTTTGCTAACTCCCTGTTTGTGAATAACTGGGACAATCGCACCATTGATCATGTTGAGATTACCGTGG
CAGAAGAAGTGGGGATCGAAGGGCGCTGGGGCTATTTTGATAAAGCCGGTCAGATGCGTGACATGATTCAGAACCACCTG
CTACAAATTCTCTGCATGATTGCGATGTCTCCGCCATCTGACCTGAGCGCAGACAGCATCCGCGATGAAAAAGTGAAAGT
ACTGAAGTCCCTGCGCCGCATCGACCGCTCCAACGTACGCGAAAAAACCGTACGCGGGCAATATACTGCGGGCTTCGCCC
AGGGCAAAAAAGTGCCGGGATATCTGGAAGAAGAGGGCGCGAACAAGAGCAGCAATACAGAAACCTTCGTGGCGATCCGC
GTCGACATTGATAACTGGCGCTGGGCCGGTGTGCCATTCTACCTGCGTACTGGTAAACGTCTGCCGACCAAATGTTCTGA
AGTCGTGGTCTATTTCAAAACACCTGAACTGAATCTGTTTAAAGAGTCGTGGCAGGATCTGCCGCAGAATAAACTGACTA
TCCGTCTGCAACCTGATGAAGGCGTGGATATCCAGGTACTGAATAAAGTTCCTGGCCTTGACCACAAACATAACCTGCAA
ATCACCAAGCTGGATCTGAGCTATTCAGAAACCTTTAATCAGACGCATCTGGCGGATGCCTATGAACGTCTGCTGCTGGA
AACCATGCGTGGTATTCAGGCACTGTTTGTACGTCGTGATGAAGTGGAAGAAGCCTGGAAATGGGTAGACTCCATTACTG
AGGCGTGGGCGATGGACAATGATGCGCCGAAACCGTATCAGGCCGGAACCTGGGGACCCGTTGCCTCGGTGGCGATGATT
ACCCGTGATGGTCGTTCCTGGAATGAGTTTGAGTAA

Upstream 100 bases:

>100_bases
ACAGTTTTCGCAAGCTCGTAAAAGCAGTACAGTGCACCGTAAGAAAATTACAAGTATACCCTGGCTTAAGTACCGGGTTA
GTTAACTTAAGGAGAATGAC

Downstream 100 bases:

>100_bases
TATCTGCGCTTATCCTTTATGGTTATTTTACCGGTAACATGATCTTGCACAGATTGTAGAACAATTTTTACACTTTCAGG
CCTCGTGCGGATTCACCCAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTKVVREALETFMKETIDEGLWD
TLSARLDFCNLDVNDTAAFNRLGAMLDQKNRITINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEIN
DQVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHL
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKSSNTETFVAIR
VDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQ
ITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMI
TRDGRSWNEFE

Sequences:

>Translated_491_residues
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTKVVREALETFMKETIDEGLWD
TLSARLDFCNLDVNDTAAFNRLGAMLDQKNRITINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEIN
DQVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHL
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKSSNTETFVAIR
VDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQ
ITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMI
TRDGRSWNEFE
>Mature_490_residues
AVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTKVVREALETFMKETIDEGLWDT
LSARLDFCNLDVNDTAAFNRLGAMLDQKNRITINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEIND
QVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHLL
QILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKSSNTETFVAIRV
DIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQI
TKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMIT
RDGRSWNEFE

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=485, Percent_Identity=37.1134020618557, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI109389365, Length=485, Percent_Identity=37.1134020618557, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI52145310, Length=496, Percent_Identity=27.0161290322581, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=99.79633401222, Blast_Score=1019, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=36.2886597938144, Blast_Score=302, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6324088, Length=477, Percent_Identity=34.5911949685535, Blast_Score=277, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=36.3057324840764, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=36.3057324840764, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI221513548, Length=490, Percent_Identity=27.9591836734694, Blast_Score=176, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55732; Mature: 55601

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTK
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHH
VVREALETFMKETIDEGLWDTLSARLDFCNLDVNDTAAFNRLGAMLDQKNRITINYFAMP
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEECC
PSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEINDQVGEYFEECQVYRIDHYLG
CHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEHHHHHC
KETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHL
HHHHHHHHHHHHHHHHEEECCCCCEECEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
YLEEEGANKSSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCEEEECCCCCCCCCCCEEEEEECCCCHHH
KESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQITKLDLSYSETFNQTHLADA
HHHHHHCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEE
TRDGRSWNEFE
EECCCCCCCCC
>Mature Secondary Structure 
AVTQTAQACDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTK
CCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHH
VVREALETFMKETIDEGLWDTLSARLDFCNLDVNDTAAFNRLGAMLDQKNRITINYFAMP
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEECC
PSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEINDQVGEYFEECQVYRIDHYLG
CHHHHHHHHCCCCCCCCCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHHCEEEEHHHHHC
KETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHL
HHHHHHHHHHHHHHHHEEECCCCCEECEEEEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCC
YLEEEGANKSSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLF
CHHHCCCCCCCCCEEEEEEEEEECCCEECCCCEEEECCCCCCCCCCCEEEEEECCCCHHH
KESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQITKLDLSYSETFNQTHLADA
HHHHHHCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEEEEEECCHHHHCCHHHHHHH
YERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHEEEE
TRDGRSWNEFE
EECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]