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The map label for this gene is hemH

Identifier: 218693937

GI number: 218693937

Start: 525366

End: 526328

Strand: Direct

Name: hemH

Synonym: EC55989_0488

Alternate gene names: 218693937

Gene position: 525366-526328 (Clockwise)

Preceding gene: 218693936

Following gene: 218693939

Centisome position: 10.19

GC content: 54.72

Gene sequence:

>963_bases
ATGCGTCAGACTAAAACCGGTATCCTGCTGGCAAACCTGGGTACGCCCGATGCCCCCACACCTGAAGCGGTAAAACGCTA
TCTGAAACAATTTTTAAGCGACAGACGCGTGGTTGATACCTCACGGTTGTTATGGTGGCCGTTGCTGCGCGGCGTGATTT
TGCCGCTGCGCTCGCCGCGTGTGGCGAAGCTGTACGCCTCGGTCTGGATGGAAGACGGCTCGCCGCTGATGGTTTACAGC
CGCCAGCAACAGCAGGCGTTGGCACAACGTTTACCGGATACGCCCGTAGCGCTGGGCATGAGCTACGGCTCGCCATCACT
GGAAAGCGCCGTCGATGAACTCCTGGCAGAGCATGTAGATCATATTGTGGTGCTGCCGCTTTATCCGCAATTCTCCTGTT
CTACGGTCGGTGCGGTATGGGATGAACTGGCACGCATTCTGGCGCGCAAACGTAGCATTCCGGGGATATCGTTTATTCGT
GATTACGCCGATAACCACGATTACATTAATGCACTGGCGAACAGCGTACGCGCTTCTTTTGCCAAACATGGCGAACCGGA
TCTGCTGCTGCTCTCTTATCATGGCATTCCTCAGCGTTATGCAGATGAAGGCGATGATTACCCGCAACGTTGCCGCACAA
CGACTCGCGAACTGGCTTCCGCACTGGGGATGGCACCGGAAAAAGTGATGATGACCTTTCAGTCGCGCTTTGGCCGGGAA
CCCTGGCTGATGCCTTATACCGACGAAACGCTGAAAATGCTCGGAGAAAAAGGCGTAGGTCATATTCAGGTGATGTGCCC
GGGCTTTGCTGCGGATTGTCTGGAGACGCTGGAAGAGATTGCCGAGCAAAACCGTGAGGTCTTCCTCGGTGCCGGCGGGA
AAAAATATGAATATATTCCGGCGCTTAATGCCACGCCGGAACATATCGAAATGATGGCCAATCTTGTTGCCGCGTATCGC
TAA

Upstream 100 bases:

>100_bases
GCGCTATTCCTTTTTCTGATTTGACCTCTCACAGCAATTAGTTCTTCTTCCTCACTTTTCCGCTACAATTATCAACAAGT
TGAATCGATAAGAGGCGGTA

Downstream 100 bases:

>100_bases
AGCTGAGCGGTAAAGAACTGAGCGCCGTCGCGAAGAGCCTCGTCGGCGGTTTTCATCATCCGTGAATAATGCAAAAAGGC
ATGCAGCGTACCTGGGTAGA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEDGSPLMVYS
RQQQQALAQRLPDTPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR

Sequences:

>Translated_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEDGSPLMVYS
RQQQQALAQRLPDTPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
>Mature_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEDGSPLMVYS
RQQQQALAQRLPDTPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=26.3473053892216, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=26.4264264264264, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=99.0625, Blast_Score=656, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=27.2189349112426, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=25.8928571428571, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=26.7657992565056, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35899; Mature: 35899

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VAKLYASVWMEDGSPLMVYSRQQQQALAQRLPDTPVALGMSYGSPSLESAVDELLAEHVD
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
HIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEC
ALNATPEHIEMMANLVAAYR
CCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VAKLYASVWMEDGSPLMVYSRQQQQALAQRLPDTPVALGMSYGSPSLESAVDELLAEHVD
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
HIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEC
ALNATPEHIEMMANLVAAYR
CCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA