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The map label for this gene is adrA

Identifier: 218693846

GI number: 218693846

Start: 428919

End: 430034

Strand: Direct

Name: adrA

Synonym: EC55989_0394

Alternate gene names: 218693846

Gene position: 428919-430034 (Clockwise)

Preceding gene: 218693845

Following gene: 218693848

Centisome position: 8.32

GC content: 53.85

Gene sequence:

>1116_bases
ATGTTCCCAAAAATAATGAATGATGAAAACTTTTTCAAAAAAGCGGCGGCGCATGGGGAGGAACCTCCTTTAACTCCTCA
AAACGAACATCAGCGGTCCGGGCTGCGCTTCGCCCGTCGCGTCAGACTACCCCGTGCGGTTGGCCTGGCTGGCATGTTCT
TACCGATTGCTTCAACGCTGGTTTCGCACCCGCCGCCGGGCTGGTGGTGGCTGGTGTTGGTCGGCTGGGCGTTCGTCTGG
CCGCATTTAGCCTGGCAGATAGCGAGCAGGGCCGTCGATCCGCTTAGCCGGGAAATTTACAACTTAAAAACCGATGCAGT
ATTAGCGGGAATGTGGGTAGGCGTAATGGGCGTAAACGTGCTGCCTTCCACCGCTATGTTGATGATTATGTGTCTGAATT
TGATGGGGGCAGGCGGCCCCCGTCTGTTTGTCGCGGGTCTGGTGTTGATGGTGGTTTCCTGCCTTGTCACCCTCGAGCTT
ACGGGCATTACCGTGTCGTTCAATAGTGCGCCGCTGGAATGGTGGCTCTCCCTTCCCATTATTGTCGTTTATCCTCTGCT
GTTTGGCTGGGTCAGCTACCAGACGGCAACCAAACTGGCGGAACATAAACGCAGGTTGCAGGTCATGAGTACCCGCGACG
GCATGACGGGCGTGTATAACCGACGTCATTGGGAAACTATGTTACGCAATGAATTTGATAACTGTCGGCGGCATAATCGC
GATGCAACGTTACTGATTATCGATATCGACCATTTCAAGAGCATCAACGATACCTGGGGTCATGATGTGGGCGATGAAGC
GATTGTGGCGCTTACCCGACAGTTACAAATTACCCTGCGCGGTAGCGATGTGATTGGTCGGTTTGGCGGCGATGAGTTTG
CAGTAATCATGTCCGGTACGCCAGCTGAGAGCGCCATTACCGCCATGTTACGGGTGCGTGAAGGGCTAAACACGTTACGC
TTGCCGAATACGCCACAGGTAACTTTACGGATTAGTGTGGGGGTTGCGCCGCTGAACCCACAAATGAGTCACTATCGTGA
GTGGTTGAAATCGGCAGATTTGGCGCTTTACAAAGCAAAGAAAGCCGGACGTAACCGCACCGAAGTGGCGGCCTGA

Upstream 100 bases:

>100_bases
ACCTGATAGTGCTAACGGGTGAGCTACGAAAGTGGCTCACCCGAAATTTCATACTTCTGCCTTTAGCCCCGTCTCTATAA
TTTGGGAAAATTGTTTCTGA

Downstream 100 bases:

>100_bases
CGTCCGGCGAAAGTCATCAGGATTTGCTGAGTTTTTCTGATTTTTCCATACACTTCGTCATCGCTTCGATCACTGCGGCA
CGGAAGCCTTTCTCTTCCAG

Product: diguanylate cyclase AdrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPPPGWWWLVLVGWAFVW
PHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLEL
TGITVSFNSAPLEWWLSLPIIVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVREGLNTLR
LPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA

Sequences:

>Translated_371_residues
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPPPGWWWLVLVGWAFVW
PHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLEL
TGITVSFNSAPLEWWLSLPIIVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVREGLNTLR
LPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA
>Mature_371_residues
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTLVSHPPPGWWWLVLVGWAFVW
PHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNVLPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLEL
TGITVSFNSAPLEWWLSLPIIVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGTPAESAITAMLRVREGLNTLR
LPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAKKAGRNRTEVAA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1786584, Length=371, Percent_Identity=99.4609164420485, Blast_Score=758, Evalue=0.0,
Organism=Escherichia coli, GI145693134, Length=159, Percent_Identity=35.2201257861635, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87081881, Length=171, Percent_Identity=35.672514619883, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787262, Length=165, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI87082007, Length=164, Percent_Identity=36.5853658536585, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788381, Length=177, Percent_Identity=29.9435028248588, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787802, Length=163, Percent_Identity=31.2883435582822, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787541, Length=179, Percent_Identity=31.8435754189944, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081977, Length=167, Percent_Identity=32.3353293413174, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87081974, Length=155, Percent_Identity=29.6774193548387, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788085, Length=180, Percent_Identity=28.3333333333333, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1787816, Length=165, Percent_Identity=29.6969696969697, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787056, Length=147, Percent_Identity=36.0544217687075, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788956, Length=150, Percent_Identity=30, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR007894 [H]

Pfam domain/function: PF00990 GGDEF; PF05230 MASE2 [H]

EC number: NA

Molecular weight: Translated: 41543; Mature: 41543

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
CCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHCCC
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHH
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
CCEEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHEEEEEECCCEEECCCCCCEEEEEECC
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
CHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHH
KAGRNRTEVAA
HCCCCCCCCCC
>Mature Secondary Structure
MFPKIMNDENFFKKAAAHGEEPPLTPQNEHQRSGLRFARRVRLPRAVGLAGMFLPIASTL
CCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
VSHPPPGWWWLVLVGWAFVWPHLAWQIASRAVDPLSREIYNLKTDAVLAGMWVGVMGVNV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHCCC
LPSTAMLMIMCLNLMGAGGPRLFVAGLVLMVVSCLVTLELTGITVSFNSAPLEWWLSLPI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCHHHHHHHHH
IVVYPLLFGWVSYQTATKLAEHKRRLQVMSTRDGMTGVYNRRHWETMLRNEFDNCRRHNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DATLLIIDIDHFKSINDTWGHDVGDEAIVALTRQLQITLRGSDVIGRFGGDEFAVIMSGT
CCEEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHEEEEEECCCEEECCCCCCEEEEEECC
PAESAITAMLRVREGLNTLRLPNTPQVTLRISVGVAPLNPQMSHYREWLKSADLALYKAK
CHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCCHHHHHHH
KAGRNRTEVAA
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]