Click here to switch to the map view.

The map label for this gene is gmhB

Identifier: 218693666

GI number: 218693666

Start: 223330

End: 223902

Strand: Direct

Name: gmhB

Synonym: EC55989_0198

Alternate gene names: 218693666

Gene position: 223330-223902 (Clockwise)

Preceding gene: 218693659

Following gene: 218693667

Centisome position: 4.33

GC content: 49.91

Gene sequence:

>573_bases
GTGGCAAAGAGCGTACCCGCAATTTTTCTTGATCGTGATGGCACCATTAATGTCGATCACGGCTATGTCCATGAGATCGA
CAACTTTGAATTTATCGACGGTGTTATTGACGCCATGCGCGAGCTAAAAAAAATGGGCTTTGCGCTGGTGGTAGTAACCA
ACCAGTCTGGCATTGCTCGCGGTAAATTTACCGAAGCACAGTTTGAAACGCTGACCGAGTGGATGGACTGGTCGCTGGCG
GACCGAGATGTCGATCTGGATGGTATCTATTATTGCCCGCATCATCCGCAGGGTAGTGTTGAAGAGTTTCGCCAGGTCTG
CGACTGCCGTAAACCACATCCGGGGATGCTTTTGTCAGCACGCGATTATTTGCATATTGATATGGCCGCTTCTTATATGG
TGGGCGATAAATTAGAAGATATGCAGGCAGCGGCTGCGGCGAACGTGGGAACAAAAGTGCTGGTGCGTACGGGTAAACCT
ATTACGCCTGAAGCAGAAAACGCGGCGGATTGGGTGTTAAATAGCCTGGCAGACCTGCCGCAAGCGATAAAAAAGCAGCA
AAAACCGGCATAA

Upstream 100 bases:

>100_bases
TCCAGACGTCTAAATCAATCAGGTTTATGCGAAGAGCACTTTCTTGCAGGTCGAAACATGCGATACTAGCGTCACATGCC
TTATTAAGGAGCTATAAAAG

Downstream 100 bases:

>100_bases
TGATTAAAAGATGAGCAATTGAAATAAAAATGCATTTTTCCACTTGTCTTCCTGAGACGACTCCCTATAATGCGCCTCCA
TCGACACGGCGGATGTGAAT

Product: D,D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLA
DRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKP
ITPEAENAADWVLNSLADLPQAIKKQQKPA

Sequences:

>Translated_190_residues
MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLA
DRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKP
ITPEAENAADWVLNSLADLPQAIKKQQKPA
>Mature_189_residues
AKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIARGKFTEAQFETLTEWMDWSLAD
RDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSARDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKPI
TPEAENAADWVLNSLADLPQAIKKQQKPA

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=190, Percent_Identity=99.4736842105263, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI87082027, Length=149, Percent_Identity=31.5436241610738, Blast_Score=78, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- InterPro:   IPR013954 [H]

Pfam domain/function: PF08645 PNK3P [H]

EC number: 3.1.1.-

Molecular weight: Translated: 21138; Mature: 21007

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIAR
CCCCCCEEEECCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
GKFTEAQFETLTEWMDWSLADRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEC
RDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKPITPEAENAADWVLNSLADLP
CCEEEEEHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
QAIKKQQKPA
HHHHHHCCCC
>Mature Secondary Structure 
AKSVPAIFLDRDGTINVDHGYVHEIDNFEFIDGVIDAMRELKKMGFALVVVTNQSGIAR
CCCCCEEEECCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
GKFTEAQFETLTEWMDWSLADRDVDLDGIYYCPHHPQGSVEEFRQVCDCRKPHPGMLLSA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEC
RDYLHIDMAASYMVGDKLEDMQAAAAANVGTKVLVRTGKPITPEAENAADWVLNSLADLP
CCEEEEEHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
QAIKKQQKPA
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11108008; 11206551; 11258796 [H]