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The map label for this gene is aidB [H]

Identifier: 218692520

GI number: 218692520

Start: 4931959

End: 4933584

Strand: Direct

Name: aidB [H]

Synonym: ECED1_4974

Alternate gene names: 218692520

Gene position: 4931959-4933584 (Clockwise)

Preceding gene: 218692519

Following gene: 218692523

Centisome position: 94.67

GC content: 54.61

Gene sequence:

>1626_bases
GTGCACTGGCAAACTCACACCGTTTTTAATCAACTTATACCATTAAATAACAGCAACTTATACCTGTCTGATGGCGCGCT
TTGCGAAGCGGTAACGCGTGAAGGTGCTAGCTGGGATAGCGATTTTCTCGCCAGTATTGGTCAGCAGTTAGGAACGGCTG
AATCCCTTGAACTGGGGCGGCTGGCGAATGTGAATCCGCCTGAATTATTGCGCTACGATGCGCAAGGACGCCGTCTGGAC
GATGTGCGTTTTCACCCCGCCTGGCACCTGCTGATGCAGGCGCTATGTACCAATCGGGTGCACAATCTTGCCTGGGAAGA
AGACGCTCGCTCCGGCGCATTTGTGGCGCGCGCGGCGCGTTTTATGTTACATGCGCAGGTTGAGGCTGGGTCGTTATGTC
CGATAACGATGACCTTTGCCGCCACGCCATTGTTGTTACAGATGTTACCCGCGCCGTTTCAGGACTGGACCACGCCGCTG
CTGAGCGATCGCTACGATTCTCACTTATTGCCAGGTGGGCAAAAACGTGGCTTGTTGATCGGCATGGGAATGACGGAAAA
GCAGGGCGGTTCCGATGTCATGAGCAACACCACCCGCGCAGAGCGTCTGGACGATGGTTCTTATCGGCTGGTGGGGCATA
AATGGTTTTTCTCGGTGCCGCAAAGCGATGCGCATCTGGTGCTGGCACAGACCGCGGGCGGTTTGTCCTGCTTTTTTGTG
CCGCGCTTTTTGCCTGACGGGCAACGCAACGCGATTCGCCTCGAGCGGCTGAAAGATAAGCTGGGTAATCGCTCTAACGC
CAGCTGCGAAGTGGAGTTTCAGGATGCCATTGGCTGGTTGTTGGGGCAGGAAGGGGAAGGAATTCGTCTGATCCTGAAAA
TGGGTGGGATGACGCGTTTTGATTGCGCCCTGGGTAGCCATGCCATGATGCGCCGTGCATTTTCGCTGGCGATTTACCAT
GCACATCAACGCCATGTTTTTGGTAATCCATTGATCCAACAGCCTCTTATGCGTCATGTCTTAAGTCGCATGGCACTTCA
GCTTGAAGGGCAAACGGCGTTGCTGTTTCGTCTTGCGCGAGCGTGGGACCGGCGCGCCGATGCCAAAGAAGCTCTGTGGG
CGCGTTTATTTACGCCTGCGGCGAAATTTGTGATCTGCAAACGTGGCATTCCGTTTGTGGCCGAAGCGATGGAGGTGCTG
GGCGGCATTGGTTATTGCGAGGAGAGCGAGCTGCCGCGGCTTTACCGGGAGATGCCGGTAAACAGTATTTGGGAAGGTTC
CGGCAATATTATGTGCCTAGATGTGCTGCGCGTTCTCAATAAGCAAGCGGGCGTATACGACTTATTGTCGGAAGCATTTG
TGGAAGTGAAAGGGCAGGATCGCTATTTTGATCGCGCGGTTCGTCGTTTACAGCAGCAGCTGCGTAAGCCAGCTGAAGAA
TTGGGGCGAGAGATTACTCATCAGCTATTCCTGCTGGGCTGCGGTGCGCAAATGTTGAAATATGCCTCTCCGCCAATGGC
GCAGGCGTGGTGTAAGGTGATGTTAGATACGCGCGGCGGCGTACGGTTGTCAGAGCAGATCCAGAATGATTTATTGCTGC
GGGCGACGGGAGGAGTGTGTTTGTAA

Upstream 100 bases:

>100_bases
ATTACATTGCTGGATAAGAATGTTTTAGCAATCTCTTTCTGTCATGAATCCATGGCAGTGACCATACTAATGGTGACTGC
CATTGATGGAGGGAGACACA

Downstream 100 bases:

>100_bases
GCGTATACGACTGATGCGACGCTGGTTTCGATTAACTAAATGAAATATTTTAAAATTGTAGGCCGGACAAGGCGCTCGCG
CCGCATCCGGCATTGTTCAT

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MHWQTHTVFNQLIPLNNSNLYLSDGALCEAVTREGASWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQGRRLD
DVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPL
LSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLDDGSYRLVGHKWFFSVPQSDAHLVLAQTAGGLSCFFV
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYH
AHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGIPFVAEAMEVL
GGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
LGREITHQLFLLGCGAQMLKYASPPMAQAWCKVMLDTRGGVRLSEQIQNDLLLRATGGVCL

Sequences:

>Translated_541_residues
MHWQTHTVFNQLIPLNNSNLYLSDGALCEAVTREGASWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQGRRLD
DVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPL
LSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLDDGSYRLVGHKWFFSVPQSDAHLVLAQTAGGLSCFFV
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYH
AHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGIPFVAEAMEVL
GGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
LGREITHQLFLLGCGAQMLKYASPPMAQAWCKVMLDTRGGVRLSEQIQNDLLLRATGGVCL
>Mature_541_residues
MHWQTHTVFNQLIPLNNSNLYLSDGALCEAVTREGASWDSDFLASIGQQLGTAESLELGRLANVNPPELLRYDAQGRRLD
DVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPL
LSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLDDGSYRLVGHKWFFSVPQSDAHLVLAQTAGGLSCFFV
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYH
AHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWDRRADAKEALWARLFTPAAKFVICKRGIPFVAEAMEVL
GGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
LGREITHQLFLLGCGAQMLKYASPPMAQAWCKVMLDTRGGVRLSEQIQNDLLLRATGGVCL

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=287, Percent_Identity=29.2682926829268, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI226958412, Length=271, Percent_Identity=25.0922509225092, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI226958414, Length=271, Percent_Identity=25.0922509225092, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI4501859, Length=252, Percent_Identity=25, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI7656849, Length=266, Percent_Identity=27.8195488721804, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI187960098, Length=274, Percent_Identity=25.1824817518248, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4557231, Length=274, Percent_Identity=25.1824817518248, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI21361497, Length=260, Percent_Identity=23.8461538461538, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI87082384, Length=541, Percent_Identity=98.7060998151571, Blast_Score=1100, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=330, Percent_Identity=25.4545454545455, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87081958, Length=258, Percent_Identity=25.968992248062, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=459, Percent_Identity=30.9368191721133, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI86563381, Length=459, Percent_Identity=30.9368191721133, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17538396, Length=271, Percent_Identity=28.7822878228782, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=267, Percent_Identity=23.5955056179775, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=270, Percent_Identity=24.0740740740741, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=261, Percent_Identity=24.5210727969349, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=269, Percent_Identity=24.5353159851301, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=268, Percent_Identity=24.2537313432836, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17505929, Length=298, Percent_Identity=26.510067114094, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356377, Length=312, Percent_Identity=25.6410256410256, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355753, Length=297, Percent_Identity=28.2828282828283, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=23.7536656891496, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646207, Length=274, Percent_Identity=25.5474452554745, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24660351, Length=279, Percent_Identity=25.4480286738351, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24666513, Length=269, Percent_Identity=22.3048327137546, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 60634; Mature: 60634

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHWQTHTVFNQLIPLNNSNLYLSDGALCEAVTREGASWDSDFLASIGQQLGTAESLELGR
CCCCHHHHHHHHCCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCC
LANVNPPELLRYDAQGRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAAR
CCCCCCHHHHEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
FMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPLLSDRYDSHLLPGGQKRGLLI
HHHHEECCCCCCCCEEHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCCCCCCCCCCCCEEE
GMGMTEKQGGSDVMSNTTRAERLDDGSYRLVGHKWFFSVPQSDAHLVLAQTAGGLSCFFV
ECCCCCCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEE
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRF
HHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCEE
DCALGSHAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLAR
HHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AWDRRADAKEALWARLFTPAAKFVICKRGIPFVAEAMEVLGGIGYCEESELPRLYREMPV
HHHHCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
NSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
CCEECCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LGREITHQLFLLGCGAQMLKYASPPMAQAWCKVMLDTRGGVRLSEQIQNDLLLRATGGVC
HHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHCCEEEEECCCCC
L
C
>Mature Secondary Structure
MHWQTHTVFNQLIPLNNSNLYLSDGALCEAVTREGASWDSDFLASIGQQLGTAESLELGR
CCCCHHHHHHHHCCCCCCCEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHCCCCC
LANVNPPELLRYDAQGRRLDDVRFHPAWHLLMQALCTNRVHNLAWEEDARSGAFVARAAR
CCCCCCHHHHEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
FMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPLLSDRYDSHLLPGGQKRGLLI
HHHHEECCCCCCCCEEHHHHHHHHHHHHCCCCHHHHCCHHHHCCCCCCCCCCCCCCCEEE
GMGMTEKQGGSDVMSNTTRAERLDDGSYRLVGHKWFFSVPQSDAHLVLAQTAGGLSCFFV
ECCCCCCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCEEEEEE
PRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDAIGWLLGQEGEGIRLILKMGGMTRF
HHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCEE
DCALGSHAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLAR
HHHHCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AWDRRADAKEALWARLFTPAAKFVICKRGIPFVAEAMEVLGGIGYCEESELPRLYREMPV
HHHHCCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
NSIWEGSGNIMCLDVLRVLNKQAGVYDLLSEAFVEVKGQDRYFDRAVRRLQQQLRKPAEE
CCEECCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LGREITHQLFLLGCGAQMLKYASPPMAQAWCKVMLDTRGGVRLSEQIQNDLLLRATGGVC
HHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHCCEEEEECCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]