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The map label for this gene is nanK [H]

Identifier: 218692464

GI number: 218692464

Start: 4869946

End: 4870821

Strand: Direct

Name: nanK [H]

Synonym: ECED1_4912

Alternate gene names: 218692464

Gene position: 4869946-4870821 (Clockwise)

Preceding gene: 218692463

Following gene: 218692465

Centisome position: 93.48

GC content: 40.41

Gene sequence:

>876_bases
ATGATAACACTGGCTGTTGATATAGGAGGAACGAAAATTTCAGCGGCGTTGATATCTGATGACGGTTTATTTTTGCTGAA
AAAACAGATATCAACACCTCATGAAAGATGTCCTGACGAAATGACAGGGGCTTTACGTCTACTGGTTTCTGAAATGAAGG
GAACAGCGGAGCGATTTGCAGTAGCATCAACAGGGATTATTAATAATGGAGTATTGACAGCTCTGAATCCAGACAATCTT
GGAGGGCTGAAAGAGTATCCTCTGAAAAATATAATGGAAGATATAACTGGTTTAAATGGAAGTGTGATAAATGATGCCCA
GGCAGCCGCATGGGCAGAATATACAGTTTTGCCAAAAGAAATTTGTGATATGGTTTTTATAACCGTTTCTACGGGGGTTG
GAGGGGGAATTGTAGTTAACAGAAAATTATTAACAGGTGTTTCTGGATTAGCCGGACATGTTGGGCATATATTGTCCGGA
GTAACGGATACAGAATGTGGATGTGGTCGTCGGGGATGCGTTGAAGCGGTTTCATCTGGTCGGGCCATCATGGGGGCAGC
AAAAAATAAACTTGCAGGATATAGCACCAAATATATTTTTGAATTAGCGAGACAGGGATATAAGGAAGCAGAATTTTTGA
CAGAGCGTTCTGCCAGTACTATTGCTGAATTAATAGTAAGTTTAAAATTACTGCTTGATTGTCAGGTTGTTGTTGTCGGA
GGAAGTGTTGGACTTGCTGATGGGTATGTTCAGAAAGTGTCGAAACATCTTTCCATATATTCTGAAATTTGTAATGTAAT
GCTGTTTCCGGCATATTTCAGAAGTGACTCTGGTCTTATTGGTGCAACTCTTTGGGACCGGGATTGTATTACTTAA

Upstream 100 bases:

>100_bases
ATTATCAAAACTTGCAGAGCGACTGCTCGAAGAACATGACAGAAACAAAAAAATGAAAATAATCTGAATAATTGCAAGAT
TGTTATATAGGTGAAAATGA

Downstream 100 bases:

>100_bases
AGTAATACTCCAGTGTATTATAAATCCGCTATTATTGTGAGGTTTAATATGGACTCCTGTATTCAGAAAAAGCAGGTTTG
GTATAAGCATCTTTCACCCA

Product: N-acetylmannosamine kinase

Products: NA

Alternate protein names: ManNAc kinase; N-acetyl-D-mannosamine kinase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MITLAVDIGGTKISAALISDDGLFLLKKQISTPHERCPDEMTGALRLLVSEMKGTAERFAVASTGIINNGVLTALNPDNL
GGLKEYPLKNIMEDITGLNGSVINDAQAAAWAEYTVLPKEICDMVFITVSTGVGGGIVVNRKLLTGVSGLAGHVGHILSG
VTDTECGCGRRGCVEAVSSGRAIMGAAKNKLAGYSTKYIFELARQGYKEAEFLTERSASTIAELIVSLKLLLDCQVVVVG
GSVGLADGYVQKVSKHLSIYSEICNVMLFPAYFRSDSGLIGATLWDRDCIT

Sequences:

>Translated_291_residues
MITLAVDIGGTKISAALISDDGLFLLKKQISTPHERCPDEMTGALRLLVSEMKGTAERFAVASTGIINNGVLTALNPDNL
GGLKEYPLKNIMEDITGLNGSVINDAQAAAWAEYTVLPKEICDMVFITVSTGVGGGIVVNRKLLTGVSGLAGHVGHILSG
VTDTECGCGRRGCVEAVSSGRAIMGAAKNKLAGYSTKYIFELARQGYKEAEFLTERSASTIAELIVSLKLLLDCQVVVVG
GSVGLADGYVQKVSKHLSIYSEICNVMLFPAYFRSDSGLIGATLWDRDCIT
>Mature_291_residues
MITLAVDIGGTKISAALISDDGLFLLKKQISTPHERCPDEMTGALRLLVSEMKGTAERFAVASTGIINNGVLTALNPDNL
GGLKEYPLKNIMEDITGLNGSVINDAQAAAWAEYTVLPKEICDMVFITVSTGVGGGIVVNRKLLTGVSGLAGHVGHILSG
VTDTECGCGRRGCVEAVSSGRAIMGAAKNKLAGYSTKYIFELARQGYKEAEFLTERSASTIAELIVSLKLLLDCQVVVVG
GSVGLADGYVQKVSKHLSIYSEICNVMLFPAYFRSDSGLIGATLWDRDCIT

Specific function: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family. NanK subfamily [H]

Homologues:

Organism=Escherichia coli, GI87082230, Length=276, Percent_Identity=53.2608695652174, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1787363, Length=262, Percent_Identity=27.8625954198473, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081733, Length=311, Percent_Identity=23.7942122186495, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.60 [H]

Molecular weight: Translated: 30770; Mature: 30770

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLAVDIGGTKISAALISDDGLFLLKKQISTPHERCPDEMTGALRLLVSEMKGTAERFA
CEEEEEECCCCEEEEEEECCCCCEEEHHHHCCCHHHCCHHHHHHHHHHHHHHHCHHHHHH
VASTGIINNGVLTALNPDNLGGLKEYPLKNIMEDITGLNGSVINDAQAAAWAEYTVLPKE
HHHCCEECCCEEEEECCCCCCCCHHCCHHHHHHHHCCCCCCEECCHHHHHHHHHEECHHH
ICDMVFITVSTGVGGGIVVNRKLLTGVSGLAGHVGHILSGVTDTECGCGRRGCVEAVSSG
HHCEEEEEEECCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCC
RAIMGAAKNKLAGYSTKYIFELARQGYKEAEFLTERSASTIAELIVSLKLLLDCQVVVVG
CEEEHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
GSVGLADGYVQKVSKHLSIYSEICNVMLFPAYFRSDSGLIGATLWDRDCIT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MITLAVDIGGTKISAALISDDGLFLLKKQISTPHERCPDEMTGALRLLVSEMKGTAERFA
CEEEEEECCCCEEEEEEECCCCCEEEHHHHCCCHHHCCHHHHHHHHHHHHHHHCHHHHHH
VASTGIINNGVLTALNPDNLGGLKEYPLKNIMEDITGLNGSVINDAQAAAWAEYTVLPKE
HHHCCEECCCEEEEECCCCCCCCHHCCHHHHHHHHCCCCCCEECCHHHHHHHHHEECHHH
ICDMVFITVSTGVGGGIVVNRKLLTGVSGLAGHVGHILSGVTDTECGCGRRGCVEAVSSG
HHCEEEEEEECCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCC
RAIMGAAKNKLAGYSTKYIFELARQGYKEAEFLTERSASTIAELIVSLKLLLDCQVVVVG
CEEEHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEE
GSVGLADGYVQKVSKHLSIYSEICNVMLFPAYFRSDSGLIGATLWDRDCIT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]