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The map label for this gene is zraR [H]

Identifier: 218692285

GI number: 218692285

Start: 4662603

End: 4663928

Strand: Direct

Name: zraR [H]

Synonym: ECED1_4711

Alternate gene names: 218692285

Gene position: 4662603-4663928 (Clockwise)

Preceding gene: 218692284

Following gene: 218692288

Centisome position: 89.5

GC content: 56.86

Gene sequence:

>1326_bases
ATGACGCACGATAATATCGATATTCTGGTGGTGGATGATGACATTAGCCACTGCACTATTTTGCAGGCTTTGCTGCGCGG
CTGGGGCTATAACGTCGCGCTGGCGAACAGCGGGCGACAGGCGCTGGAGCAGGTGCGGGAACAGGTTTTTGATCTTGTGC
TTTGCGATGTACGAATGGCAGAGATGGATGGTATCGCCACGCTAAAAGAGATCAAAACATTAAACCCCGCGATTCCGGTG
CTGATTATGACCGCGTACTCCAGCGTCGAGACGGCGGTAGAGGCGTTGAAAACCGGGGCGCTGGATTATCTCATCAAGCC
GCTGGATTTCGATAACCTGCAGGCGACGCTGGAAAAGGCGCTCGCGCATACACACAGTGTTGACGCTGAAACGCCTGCGG
TGTCTGCCAGCCAGTTCGGTATGGTCGGTAAAAGCCCGGCGATGCAACACCTGCTCAGTGAAATCGCCCTCGTCGCGCCA
TCGGAAGCCACGGTGCTGATCCACGGCGATTCCGGCACCGGTAAAGAGCTGGTCGCCAGGGCGATTCACGCCAGTAGCGC
ACGTAGCGAAAAACCGCTGGTAACGCTCAACTGCGCGGCGCTCAACGAATCCTTGCTGGAGTCTGAATTGTTCGGTCACG
AAAAACGGGCGTTTACCGGGGCCGACAAACGCCGGGAAGGGCGCTTTGTTGAGGCGGACGGCGGCACGCTGTTTCTCGAT
GAAATTGGCGATATCTCGCCGATGATGCAGGTTCGTCTGCTGCGTGCGATTCAGGAGCGCGAAGTTCAGCGTGTCGGCAG
CAACCAGACCATCTCGGTTGATGTCCGGCTGATTGCGGCGACTCATCGCGATCTTGCCGCAGAGGTGAATGCCGGGCGTT
TTCGCCAGGATCTCTACTATCGCCTGAACGTGGTGGCGATTGAAGTACCATCGCTGCGTCAGCGGCGGGAAGATATTCCT
CTGCTGGCAAACCATTTTCTTCAGCGCTTTGCCGAACGTAATCGCAAGGCGGTAAAAGGCTTTACGCCCCAGGCGATGGA
TCTGCTGATTCATTACGACTGGCCGGGAAATATTCGTGAACTGGAAAACGCGGTGGAACGGGCGGTGGTGCTGCTGACCG
GGGAATATATTTCCGAACGCGAGCTGCCGCTGGCGATTGCCAGTACGCCGATCCCGCTGGTACAAAGTCAGGATATTCAG
CCGCTGGTGGAAGTCGAAAAAGAGGTGATTCTGGCGGCGCTGGAGAAAACAGGCGGCAACAAAACCGAAGCCGCCCGCCA
GTTAGGGATCACGCGCAAAACGCTATTGGCAAAACTGTCGCGTTAG

Upstream 100 bases:

>100_bases
AACAACACGGTGGTACAATTCAGGTCGCAAGCCAGGAGGGAAAAGGCGCAACGTTCACCCTTTGGCTTCCGGTCAATATT
ACGCGTAAGGACCCACAAGG

Downstream 100 bases:

>100_bases
TTCTGCTCGCGTTCGATAGCGCGCCAGCCGATATCTTTCCGGCAGAAGCAGTCGTCCCAATGGATATCGGTCATTAAGGC
ATAAGCGCGTTTCTGCGCTT

Product: transcriptional regulatory protein ZraR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKTLNPAIPV
LIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSVDAETPAVSASQFGMVGKSPAMQHLLSEIALVAP
SEATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKRAFTGADKRREGRFVEADGGTLFLD
EIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGRFRQDLYYRLNVVAIEVPSLRQRREDIP
LLANHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIASTPIPLVQSQDIQ
PLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR

Sequences:

>Translated_441_residues
MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKTLNPAIPV
LIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSVDAETPAVSASQFGMVGKSPAMQHLLSEIALVAP
SEATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKRAFTGADKRREGRFVEADGGTLFLD
EIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGRFRQDLYYRLNVVAIEVPSLRQRREDIP
LLANHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIASTPIPLVQSQDIQ
PLVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR
>Mature_440_residues
THDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKTLNPAIPVL
IMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHSVDAETPAVSASQFGMVGKSPAMQHLLSEIALVAPS
EATVLIHGDSGTGKELVARAIHASSARSEKPLVTLNCAALNESLLESELFGHEKRAFTGADKRREGRFVEADGGTLFLDE
IGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGRFRQDLYYRLNVVAIEVPSLRQRREDIPL
LANHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRELENAVERAVVLLTGEYISERELPLAIASTPIPLVQSQDIQP
LVEVEKEVILAALEKTGGNKTEAARQLGITRKTLLAKLSR

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=98.4126984126984, Blast_Score=882, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=447, Percent_Identity=48.7695749440716, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788905, Length=445, Percent_Identity=44.4943820224719, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1790299, Length=462, Percent_Identity=41.7748917748918, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI87082117, Length=315, Percent_Identity=48.2539682539683, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1789087, Length=313, Percent_Identity=46.3258785942492, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI87082152, Length=310, Percent_Identity=47.0967741935484, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1789233, Length=318, Percent_Identity=42.1383647798742, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1786524, Length=329, Percent_Identity=43.161094224924, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI87081872, Length=315, Percent_Identity=42.8571428571429, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1787583, Length=234, Percent_Identity=42.7350427350427, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=38.1526104417671, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI87081858, Length=287, Percent_Identity=33.4494773519164, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789149, Length=112, Percent_Identity=33.9285714285714, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789402, Length=119, Percent_Identity=32.7731092436975, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786784, Length=124, Percent_Identity=28.2258064516129, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI1786911, Length=131, Percent_Identity=30.5343511450382, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI145693157, Length=115, Percent_Identity=34.7826086956522, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48583; Mature: 48452

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMA
CCCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
EMDGIATLKEIKTLNPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHH
LAHTHSVDAETPAVSASQFGMVGKSPAMQHLLSEIALVAPSEATVLIHGDSGTGKELVAR
HHHHCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
AIHASSARSEKPLVTLNCAALNESLLESELFGHEKRAFTGADKRREGRFVEADGGTLFLD
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCEEECCCCEEEEC
EIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGRFRQDLYY
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEHHHHHHHHCCCHHHHHHHHE
RLNVVAIEVPSLRQRREDIPLLANHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRE
EEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCCCHHH
LENAVERAVVLLTGEYISERELPLAIASTPIPLVQSQDIQPLVEVEKEVILAALEKTGGN
HHHHHHHEEEEEECCHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
KTEAARQLGITRKTLLAKLSR
HHHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
THDNIDILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMA
CCCCEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
EMDGIATLKEIKTLNPAIPVLIMTAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKA
HHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHH
LAHTHSVDAETPAVSASQFGMVGKSPAMQHLLSEIALVAPSEATVLIHGDSGTGKELVAR
HHHHCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
AIHASSARSEKPLVTLNCAALNESLLESELFGHEKRAFTGADKRREGRFVEADGGTLFLD
HHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCEEECCCCEEEEC
EIGDISPMMQVRLLRAIQEREVQRVGSNQTISVDVRLIAATHRDLAAEVNAGRFRQDLYY
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEHHHHHHHHCCCHHHHHHHHE
RLNVVAIEVPSLRQRREDIPLLANHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRE
EEEEEEEECCHHHHHHCCCCHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCCCHHH
LENAVERAVVLLTGEYISERELPLAIASTPIPLVQSQDIQPLVEVEKEVILAALEKTGGN
HHHHHHHEEEEEECCHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
KTEAARQLGITRKTLLAKLSR
HHHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]