Click here to switch to the map view.

The map label for this gene is oxyR

Identifier: 218692249

GI number: 218692249

Start: 4616490

End: 4617407

Strand: Direct

Name: oxyR

Synonym: ECED1_4668

Alternate gene names: 218692249

Gene position: 4616490-4617407 (Clockwise)

Preceding gene: 218692248

Following gene: 218692251

Centisome position: 88.62

GC content: 55.56

Gene sequence:

>918_bases
ATGAATATTCGTGATCTTGAGTACCTGGTGGCATTGGCCGAACACCGCCATTTTCGGCGTGCGGCAGATTCCTGCCACGT
TAGCCAGCCGACGCTTAGCGGGCAAATTCGTAAGCTGGAAGATGAGTTGGGCGTGATGTTGCTGGAGCGGACCAGCCGTA
AAGTGTTGTTCACCCAGGCGGGAATGCTGCTGGTGGATCAGGCGCGTACCGTACTGCGTGAGGTGAAAGTCCTTAAAGAG
ATGGCAAGCCAGCAGGGCGAGACGATGTCCGGGCCGCTGCATATTGGTTTGATTCCCACGGTTGGACCGTACCTGCTACC
GCATATTATCCCGATGCTGCACCAGACCTTTCCAAAGCTGGAAATGTATCTGCATGAAGCACAGACCCACCAGTTACTGG
CGCAACTGGACAGCGGCAAACTCGATTGCGTGATCCTCGCGCTGGTGAAAGAGAGCGAAGCATTCATTGAAGTGCCGTTG
TTTGATGAGCCAATGTTGCTGGCTATCTATGAAGACCACCCGTGGGCGAACCGCGAATGTGTACCGATGGCCGATCTGGC
AGGGGAAAAACTGCTGATGCTGGAAGATGGTCACTGTTTGCGCGATCAGGCAATGGGTTTCTGTTTTGAAGCCGGGGCGG
ATGAAGATACACACTTCCGCGCGACCAGCCTGGAAACTCTGCGCAACATGGTGGCGGCAGGTAGCGGGATCACTTTACTG
CCTGCGCTGGCTGTGCCGCCGGAACGCAAACGCGATGGGGTTGTTTATCTGCCGTGCATTAAGCCGGAACCACGCCGCAC
TATTGGCCTGGTTTATCGTCCTGGCTCACCGCTGCGCAGCCGCTATGAGCAGCTGGCAGAGGCCATCCGCGCAAGAATGG
ATGGCCATTTCGATAAAGTGTTAAAACAGGCGGTTTAA

Upstream 100 bases:

>100_bases
GTTTCTGTGAGCAATTATCAGTCAGAATGCTTGATAGGGATAATCGTTCGTTGCTATGCTACCTATCGCCGCGAACTATC
GTGGCAATGGAGGATGGATA

Downstream 100 bases:

>100_bases
GCCATTTAGCGCAGCTACCCGATAGGCTTCCGCCATCGTCGGGTAGTTAAAGGTGGTGTTGACGAAGTACTCAATAGTGT
TGCCGCCACCTTTCTGTTCC

Product: DNA-binding transcriptional regulator OxyR

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGMLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPL
FDEPMLLAIYEDHPWANRECVPMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPPERKRDGVVYLPCIKPEPRRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKVLKQAV

Sequences:

>Translated_305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGMLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPL
FDEPMLLAIYEDHPWANRECVPMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPPERKRDGVVYLPCIKPEPRRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKVLKQAV
>Mature_305_residues
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQAGMLLVDQARTVLREVKVLKE
MASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKLEMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPL
FDEPMLLAIYEDHPWANRECVPMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
PALAVPPERKRDGVVYLPCIKPEPRRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKVLKQAV

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1790399, Length=305, Percent_Identity=100, Blast_Score=623, Evalue=1e-180,
Organism=Escherichia coli, GI157672245, Length=273, Percent_Identity=30.7692307692308, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI145693105, Length=283, Percent_Identity=27.5618374558304, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787879, Length=248, Percent_Identity=31.8548387096774, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788887, Length=244, Percent_Identity=31.1475409836066, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787530, Length=253, Percent_Identity=26.0869565217391, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1788748, Length=290, Percent_Identity=27.2413793103448, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790208, Length=261, Percent_Identity=29.8850574712644, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI2367136, Length=243, Percent_Identity=27.5720164609054, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=27.8884462151394, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=28.9655172413793, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790262, Length=255, Percent_Identity=27.843137254902, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789506, Length=238, Percent_Identity=25.2100840336134, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788296, Length=243, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693193, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788626, Length=294, Percent_Identity=25.1700680272109, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI48994962, Length=265, Percent_Identity=26.4150943396226, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787806, Length=289, Percent_Identity=21.7993079584775, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=301, Percent_Identity=22.5913621262458, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OXYR_ECO57 (P0ACQ6)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B91240
- PIR:   G86087
- RefSeq:   NP_290598.1
- RefSeq:   NP_312917.1
- ProteinModelPortal:   P0ACQ6
- SMR:   P0ACQ6
- EnsemblBacteria:   EBESCT00000027896
- EnsemblBacteria:   EBESCT00000058257
- GeneID:   914984
- GeneID:   960171
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5519
- KEGG:   ecs:ECs4890
- GeneTree:   EBGT00050000008327
- HOGENOM:   HBG685425
- OMA:   ANRECVL
- ProtClustDB:   PRK11151
- BioCyc:   ECOL83334:ECS4890-MONOMER
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00039

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate

EC number: NA

Molecular weight: Translated: 34277; Mature: 34277

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
GMLLVDQARTVLREVKVLKEMASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
EMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPLFDEPMLLAIYEDHPWANREC
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEECCCCCCCEEEEEECCCCCCCCCC
VPMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
CCHHHCCCCEEEEEECCCHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
PALAVPPERKRDGVVYLPCIKPEPRRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKV
HCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHH
LKQAV
HHHCC
>Mature Secondary Structure
MNIRDLEYLVALAEHRHFRRAADSCHVSQPTLSGQIRKLEDELGVMLLERTSRKVLFTQA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECC
GMLLVDQARTVLREVKVLKEMASQQGETMSGPLHIGLIPTVGPYLLPHIIPMLHQTFPKL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
EMYLHEAQTHQLLAQLDSGKLDCVILALVKESEAFIEVPLFDEPMLLAIYEDHPWANREC
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEECCCCCCCEEEEEECCCCCCCCCC
VPMADLAGEKLLMLEDGHCLRDQAMGFCFEAGADEDTHFRATSLETLRNMVAAGSGITLL
CCHHHCCCCEEEEEECCCHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
PALAVPPERKRDGVVYLPCIKPEPRRTIGLVYRPGSPLRSRYEQLAEAIRARMDGHFDKV
HCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHH
LKQAV
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796