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The map label for this gene is ubiB [H]

Identifier: 218692129

GI number: 218692129

Start: 4477200

End: 4478840

Strand: Direct

Name: ubiB [H]

Synonym: ECED1_4539

Alternate gene names: 218692129

Gene position: 4477200-4478840 (Clockwise)

Preceding gene: 218692128

Following gene: 218692130

Centisome position: 85.94

GC content: 49.97

Gene sequence:

>1641_bases
ATGACGCCAGGTGAAGTACGGCGCCTATATTTCATCATTCGCACTTTTTTAAGCTACGGACTTGATGAACTGATCCCCAA
AATGCGTATCACCCTGCCGCTACGGCTATGGCGATACTCATTATTCTGGATGCCAAATCGGCATAAAGACAAACCTTTAG
GTGAGCGACTACGACTGGCCCTGCAAGAACTGGGACCGGTATGGATCAAGTTCGGGCAGATGTTATCAACCCGCCGCGAT
CTTTTTCCGCCGCATATTGCCGATCAGCTGGCGTTATTGCAGGACAAAGTCGCTCCGTTTGATGGCAAGCTGGCGAAGCA
GCAGATTGAAGCTGCAATGGGCGGCTTGCCGGTAGAAGCGTGGTTTGACGATTTTGAAATCAAGCCGCTGGCTTCTGCTT
CTATCGCCCAGGTTCATACCGCGCGATTGAAATCGAATGGTAAAGAGGTGGTGATTAAAGTTATCCGCCCGGATATTTTG
CCGGTCATTAAAGCGGATCTGAAACTTATTTACCGTCTGGCTCGCTGGGTGCCGCGTTTGCTGCCGGATGGTCGCCGTCT
GCGCCCAACCGAAGTGGTGCGCGAGTACGAAAAGACCTTGATTGATGAACTGAATTTGCTGCGGGAATCTGCCAACGCCA
TTCAGCTTCGACGCAATTTTGAAGACAGCCCGATGCTCTACATCCCGGAAGTTTACCCTGACTATTGTAGTGAAGGGATG
ATGGTGATGGAGCGTATTTACGGCATTCCGGTGTCTGATGTTGCGACGCTGGAGAAAAACGGCACCAACATGAAATTGCT
GGCGGAACGCGGCGTGCAGGTGTTCTTCACTCAGGTCTTTCGCGACAGCTTTTTCCATGCTGATATGCACCCTGGCAACA
TCTTCGTAAGCTATGAACACCCGGAAAACCCGAAATATATCGGCATTGATTGCGGGATTGTTGGCTCGCTAAACAAAGAA
GATAAACGCTATCTGGCGGAAAACTTTATCGCCTTCTTTAATCGCGACTATCGCAAAGTGGCAGAGCTACACGTCGATTC
TGGTTGGGTGCCACCAGATACCAACGTTGAAGAGTTCGAATTTGCCATTCGTACGGTCTGTGAACCTATCTTTGAGAAAC
CGCTGGCCGAAATTTCGTTTGGACATGTACTGTTAAATCTGTTTAATACGGCGCGTCGCTTCAATATGGAAGTGCAGCCG
CAACTGGTGTTACTCCAGAAAACCCTGCTCTACGTCGAAGGGGTAGGACGCCAGCTTTATCCGCAACTCGATTTATGGAA
AACGGCGAAGCCTTTCCTGGAGTCGTGGATTAAAGATCAGGTCGGTATTCCTGCGCTGGTGAGAGCATTTAAAGAAAAAG
CGCCGTTCTGGGTCGAAAAAATGCCAGAACTGCCCGAACTGGTTTACGACAGTTTGCGCCAGGGCAAGTATTTACAGCAT
AGTGTTGATAAGATTGCCCGCGAGCTTCAGTCAAATCATGTACGTCAGGGACAATCGCGTTATTTTCTCGGAATTGGCGC
TACGTTAGTATTAAGTGGCACATTCTTGTTGGTCAGCCGACCTGAATGGGGGTTGATGCCCGGCTGGTTAATGGCAGGTG
GTCTGATCGCCTGGTTTGTCGGTTGGCGCAAAACACGCTGA

Upstream 100 bases:

>100_bases
CACCCGGTCCGCTTGAAGTGGCCTGGTTTGCGGAAGAGACGGCTGCCGTCGAGCGTGCTGTTGATGCCCTGACCAAACGG
CTGGAAAAACTGGAGGCTAA

Downstream 100 bases:

>100_bases
TTTTTTCATCGCTCAAGGCGGGCCGTGTAACGTATAATGCGGCTTTGTTTAATCATCATCTACCACAGAGGAACATGTAT
GGGTGGTATCAGTATTTGGC

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLALQELGPVWIKFGQMLSTRRD
LFPPHIADQLALLQDKVAPFDGKLAKQQIEAAMGGLPVEAWFDDFEIKPLASASIAQVHTARLKSNGKEVVIKVIRPDIL
PVIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGM
MVMERIYGIPVSDVATLEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKE
DKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQP
QLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKEKAPFWVEKMPELPELVYDSLRQGKYLQH
SVDKIARELQSNHVRQGQSRYFLGIGATLVLSGTFLLVSRPEWGLMPGWLMAGGLIAWFVGWRKTR

Sequences:

>Translated_546_residues
MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLALQELGPVWIKFGQMLSTRRD
LFPPHIADQLALLQDKVAPFDGKLAKQQIEAAMGGLPVEAWFDDFEIKPLASASIAQVHTARLKSNGKEVVIKVIRPDIL
PVIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGM
MVMERIYGIPVSDVATLEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKE
DKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQP
QLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKEKAPFWVEKMPELPELVYDSLRQGKYLQH
SVDKIARELQSNHVRQGQSRYFLGIGATLVLSGTFLLVSRPEWGLMPGWLMAGGLIAWFVGWRKTR
>Mature_545_residues
TPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLALQELGPVWIKFGQMLSTRRDL
FPPHIADQLALLQDKVAPFDGKLAKQQIEAAMGGLPVEAWFDDFEIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILP
VIKADLKLIYRLARWVPRLLPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGMM
VMERIYGIPVSDVATLEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPENPKYIGIDCGIVGSLNKED
KRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKEKAPFWVEKMPELPELVYDSLRQGKYLQHS
VDKIARELQSNHVRQGQSRYFLGIGATLVLSGTFLLVSRPEWGLMPGWLMAGGLIAWFVGWRKTR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=272, Percent_Identity=27.9411764705882, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI32261307, Length=320, Percent_Identity=24.0625, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI40254938, Length=256, Percent_Identity=28.125, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI217035081, Length=223, Percent_Identity=28.2511210762332, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI34147522, Length=213, Percent_Identity=28.6384976525822, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI2367309, Length=546, Percent_Identity=99.6336996336996, Blast_Score=1112, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=285, Percent_Identity=27.3684210526316, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32565180, Length=304, Percent_Identity=25.3289473684211, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325148, Length=441, Percent_Identity=23.5827664399093, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323282, Length=297, Percent_Identity=23.9057239057239, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=201, Percent_Identity=27.363184079602, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24662575, Length=246, Percent_Identity=32.1138211382114, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI22024280, Length=257, Percent_Identity=31.5175097276265, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63218; Mature: 63086

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLA
CCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDKVAPFDGKLAKQQIEAAMGGLPVEA
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
WFDDFEIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIKADLKLIYRLARWVPRL
HCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHH
LPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHH
MVMERIYGIPVSDVATLEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEH
HHHHHHHCCCCHHHHHHHCCCCCEEHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PENPKYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFE
CCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PQLDLWKTAKPFLESWIKDQVGIPALVRAFKEKAPFWVEKMPELPELVYDSLRQGKYLQH
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCHHHHH
SVDKIARELQSNHVRQGQSRYFLGIGATLVLSGTFLLVSRPEWGLMPGWLMAGGLIAWFV
HHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHH
GWRKTR
HHHCCC
>Mature Secondary Structure 
TPGEVRRLYFIIRTFLSYGLDELIPKMRITLPLRLWRYSLFWMPNRHKDKPLGERLRLA
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHH
LQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDKVAPFDGKLAKQQIEAAMGGLPVEA
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHH
WFDDFEIKPLASASIAQVHTARLKSNGKEVVIKVIRPDILPVIKADLKLIYRLARWVPRL
HCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHH
LPDGRRLRPTEVVREYEKTLIDELNLLRESANAIQLRRNFEDSPMLYIPEVYPDYCSEGM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHH
MVMERIYGIPVSDVATLEKNGTNMKLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEH
HHHHHHHCCCCHHHHHHHCCCCCEEHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PENPKYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFE
CCCCCEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
FAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLY
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHC
PQLDLWKTAKPFLESWIKDQVGIPALVRAFKEKAPFWVEKMPELPELVYDSLRQGKYLQH
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHCCHHHHH
SVDKIARELQSNHVRQGQSRYFLGIGATLVLSGTFLLVSRPEWGLMPGWLMAGGLIAWFV
HHHHHHHHHHHHHHHCCCCCEEEEECHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHHH
GWRKTR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA