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The map label for this gene is tkt1 [H]

Identifier: 218692108

GI number: 218692108

Start: 4455256

End: 4457253

Strand: Direct

Name: tkt1 [H]

Synonym: ECED1_4517

Alternate gene names: 218692108

Gene position: 4455256-4457253 (Clockwise)

Preceding gene: 218692107

Following gene: 218692119

Centisome position: 85.52

GC content: 54.95

Gene sequence:

>1998_bases
ATGAATTTACAATTACTGGCTAATGCCATCCGAATGTTAAGTGTTGATGCGATCCAGAAAGCGAACTCCGGTCATCCGGG
CGCGCCGATGGGGATGGCGGATATTGCCGAAGTGGTCTGGCGTCGTCACCTGCGTCATAACCCAAAAAATCCGCAGTGGT
TTAACCGCGACCGCTATGTTCAGTCGAACGGTCACGGCTCCATGTTGATTTACGCTTTGCTGCATCTTACAGGCTACGAC
CTGTCGATGGATGATATTCGCGACTTTCGTCAGCTCCACTCCCGCACGCCGGGTCATCCAGAATATGGTTATACGCCGGG
TGTTGAAACCACCACCGGCCCGTTGGGGCAGGGCGTAGCTAATGCGGTGGGGATGGCGATTGCGGAGAAGGCGCTGGCGG
CAGAATTTAACAAACCGGGCTTTAATATTGTTGATCATCACACATGGCTATTTTTGGGTGATGGCTGCCTGATGGAAGGG
ATCTCCCACGAGGCCTGTGGTCTTGCAGGAACGCTGAAGCTCGGCAATCTGATTGCTATCTGGGACGATAACGGTATTTC
GATCGATGGTCACGTAGAAGGCTGGTTCGCTGAAGATACGGCTGCCCGTTTTCGTGCCTACGGCTGGCATGTCATTGAAG
GCGTTGATGGTCACGATCCAGAAGCGGTAGATGCTGCGGTGCGTGAAGCGAAAAGCGTCACGGATAAGCCCAGTCTGCTG
TGCTGCAAAACGATTATCGGTTTTGGTTCGCCAAATAAAGCCAACAGCCACGATTGCCACGGCTCGGCGCTGGGTGCAGA
TGAAGTGGCGCTGGTGCGTGAACGTCTGCAATGGCCGTATGCCCCTTTCGAAATTCCTGGTGAAATTTATGCCGAATGGG
ATGCGACCGAGAAAGGCGCGCAGGTTCAACAGGAATGGGATGCACTGTTTGCCGACTACGCGAAGCAGTGGCCGGAACTG
GCGGCGGAGTTTACTCGTCGCATGAAGGGTGATTTGCCTGCTGGCTGGGCCGAGAATATGCAGAAATATGTGCACGATCT
GCAATCCCATCCGGCGGCGCTGGCAACCCGTCAGGTCAGCCAGAAATGCCTCAATCACTTCGCGGATATGCTGCCGGAAC
TGATGGGCGGCTCGGCGGACTTGTCGCCCTCTAACCTGACTCGCCATCAGAAATCGGTTGATTTCACCGGGGAAAATCCG
GCGGGGAATTACATCTCCTATGGCGTGCGTGAATTTGGTATGTCGGCCATCATGAACGGTCTTGCGCTGCATGGTGGGTT
TATCCCTTACGGCGGTACTTTCCTGATGTTTATGGAATATGCGCGTAATGCACTGCGCATGGCGGCGCTGATGAAGATCC
GCTCGGTGTTTGTTTATACCCACGATACCATCGGCCTGGGCGAAGACGGCCCGACACATCAGCCCGTTGAGCAACTGGCG
TCGCTGCGTCTGACGCCGAATATGGAAACCTGGCGCGGTTGCGATCAGGTGGAAGTGGCGGTAGCCTGGCAACAGGCGAT
TGAGCGCAAAGATGGCCCAACGTCGTTGGTATTAACGCGCCAACCTCTGGCGCAACAGCCGCGCACCGCTGCACAGTTGG
CAGAGATTGCGCGTGGTGGTTATGTACTGAGTGATTGTGACGGTCAGCCTGAGATGATCCTCATTTCTGCGGGTTCAGAG
ATTGAGTTAGTGGTCAGCGCCGCAAAAGCGTTAACGGAAGAAGGGCGTAAAGTTCGCGTGGTTTCTATGCCGTGTACCGA
GCGTTTCGATAATCAGGATGCGGCGTACAAAGAATCGGTATTGCCAAAAGCTGTACGCAAACGTCTGGCGGTAGAAGCCA
GCATCGCCGGATTCTGGGAACGCTACGTGGGCCTGGACGGTAAAGTGATCGGCATGACGAGCTTTGGTGAGTCTGCTCCG
GCGAATGTGTTGTTCAAACACTTTGGTGTTACGCCGGAAAATGTCCTGGCGCAGGCGCGTGAGCTACTGAACAGCTAA

Upstream 100 bases:

>100_bases
TAATGAGCAGACCGCGCCCGACAGAAATGACAGTGGCCTGTGCTAACTAATTCGAGATTAGCGGGCTGGTTTCAGCCCGC
CAGACAGAGAGAGCTGAAGT

Downstream 100 bases:

>100_bases
ACCTGCACAAGGGGTGAAAGGATGACCTTTTACCCCTTGAAACGGGAGCCAAGAAACTCTTCACGGGTGCGGTATTTCTC
GTAATGCGCCTTGTTTTTAT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 665; Mature: 665

Protein sequence:

>665_residues
MNLQLLANAIRMLSVDAIQKANSGHPGAPMGMADIAEVVWRRHLRHNPKNPQWFNRDRYVQSNGHGSMLIYALLHLTGYD
LSMDDIRDFRQLHSRTPGHPEYGYTPGVETTTGPLGQGVANAVGMAIAEKALAAEFNKPGFNIVDHHTWLFLGDGCLMEG
ISHEACGLAGTLKLGNLIAIWDDNGISIDGHVEGWFAEDTAARFRAYGWHVIEGVDGHDPEAVDAAVREAKSVTDKPSLL
CCKTIIGFGSPNKANSHDCHGSALGADEVALVRERLQWPYAPFEIPGEIYAEWDATEKGAQVQQEWDALFADYAKQWPEL
AAEFTRRMKGDLPAGWAENMQKYVHDLQSHPAALATRQVSQKCLNHFADMLPELMGGSADLSPSNLTRHQKSVDFTGENP
AGNYISYGVREFGMSAIMNGLALHGGFIPYGGTFLMFMEYARNALRMAALMKIRSVFVYTHDTIGLGEDGPTHQPVEQLA
SLRLTPNMETWRGCDQVEVAVAWQQAIERKDGPTSLVLTRQPLAQQPRTAAQLAEIARGGYVLSDCDGQPEMILISAGSE
IELVVSAAKALTEEGRKVRVVSMPCTERFDNQDAAYKESVLPKAVRKRLAVEASIAGFWERYVGLDGKVIGMTSFGESAP
ANVLFKHFGVTPENVLAQARELLNS

Sequences:

>Translated_665_residues
MNLQLLANAIRMLSVDAIQKANSGHPGAPMGMADIAEVVWRRHLRHNPKNPQWFNRDRYVQSNGHGSMLIYALLHLTGYD
LSMDDIRDFRQLHSRTPGHPEYGYTPGVETTTGPLGQGVANAVGMAIAEKALAAEFNKPGFNIVDHHTWLFLGDGCLMEG
ISHEACGLAGTLKLGNLIAIWDDNGISIDGHVEGWFAEDTAARFRAYGWHVIEGVDGHDPEAVDAAVREAKSVTDKPSLL
CCKTIIGFGSPNKANSHDCHGSALGADEVALVRERLQWPYAPFEIPGEIYAEWDATEKGAQVQQEWDALFADYAKQWPEL
AAEFTRRMKGDLPAGWAENMQKYVHDLQSHPAALATRQVSQKCLNHFADMLPELMGGSADLSPSNLTRHQKSVDFTGENP
AGNYISYGVREFGMSAIMNGLALHGGFIPYGGTFLMFMEYARNALRMAALMKIRSVFVYTHDTIGLGEDGPTHQPVEQLA
SLRLTPNMETWRGCDQVEVAVAWQQAIERKDGPTSLVLTRQPLAQQPRTAAQLAEIARGGYVLSDCDGQPEMILISAGSE
IELVVSAAKALTEEGRKVRVVSMPCTERFDNQDAAYKESVLPKAVRKRLAVEASIAGFWERYVGLDGKVIGMTSFGESAP
ANVLFKHFGVTPENVLAQARELLNS
>Mature_665_residues
MNLQLLANAIRMLSVDAIQKANSGHPGAPMGMADIAEVVWRRHLRHNPKNPQWFNRDRYVQSNGHGSMLIYALLHLTGYD
LSMDDIRDFRQLHSRTPGHPEYGYTPGVETTTGPLGQGVANAVGMAIAEKALAAEFNKPGFNIVDHHTWLFLGDGCLMEG
ISHEACGLAGTLKLGNLIAIWDDNGISIDGHVEGWFAEDTAARFRAYGWHVIEGVDGHDPEAVDAAVREAKSVTDKPSLL
CCKTIIGFGSPNKANSHDCHGSALGADEVALVRERLQWPYAPFEIPGEIYAEWDATEKGAQVQQEWDALFADYAKQWPEL
AAEFTRRMKGDLPAGWAENMQKYVHDLQSHPAALATRQVSQKCLNHFADMLPELMGGSADLSPSNLTRHQKSVDFTGENP
AGNYISYGVREFGMSAIMNGLALHGGFIPYGGTFLMFMEYARNALRMAALMKIRSVFVYTHDTIGLGEDGPTHQPVEQLA
SLRLTPNMETWRGCDQVEVAVAWQQAIERKDGPTSLVLTRQPLAQQPRTAAQLAEIARGGYVLSDCDGQPEMILISAGSE
IELVVSAAKALTEEGRKVRVVSMPCTERFDNQDAAYKESVLPKAVRKRLAVEASIAGFWERYVGLDGKVIGMTSFGESAP
ANVLFKHFGVTPENVLAQARELLNS

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=587, Percent_Identity=26.7461669505963, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI4507521, Length=587, Percent_Identity=26.7461669505963, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI133778974, Length=580, Percent_Identity=24.6551724137931, Blast_Score=132, Evalue=2e-30,
Organism=Escherichia coli, GI48994911, Length=658, Percent_Identity=68.693009118541, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=65.158371040724, Blast_Score=926, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=586, Percent_Identity=25.5972696245734, Blast_Score=149, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=47.7611940298507, Blast_Score=613, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319593, Length=674, Percent_Identity=45.6973293768546, Blast_Score=579, Evalue=1e-166,
Organism=Drosophila melanogaster, GI45551847, Length=688, Percent_Identity=25.2906976744186, Blast_Score=159, Evalue=7e-39,
Organism=Drosophila melanogaster, GI45550715, Length=688, Percent_Identity=25.2906976744186, Blast_Score=159, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24645119, Length=652, Percent_Identity=24.5398773006135, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24666278, Length=249, Percent_Identity=32.5301204819277, Blast_Score=112, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72939; Mature: 72939

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00334 MYB_2 ; PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQLLANAIRMLSVDAIQKANSGHPGAPMGMADIAEVVWRRHLRHNPKNPQWFNRDRYV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
QSNGHGSMLIYALLHLTGYDLSMDDIRDFRQLHSRTPGHPEYGYTPGVETTTGPLGQGVA
ECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
NAVGMAIAEKALAAEFNKPGFNIVDHHTWLFLGDGCLMEGISHEACGLAGTLKLGNLIAI
HHHHHHHHHHHHHHHCCCCCCCEECCCEEEEECCCHHHHCCCCHHCCCEEEEECCCEEEE
WDDNGISIDGHVEGWFAEDTAARFRAYGWHVIEGVDGHDPEAVDAAVREAKSVTDKPSLL
ECCCCEEECCCCCCEECHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHH
CCKTIIGFGSPNKANSHDCHGSALGADEVALVRERLQWPYAPFEIPGEIYAEWDATEKGA
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCCCHH
QVQQEWDALFADYAKQWPELAAEFTRRMKGDLPAGWAENMQKYVHDLQSHPAALATRQVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
QKCLNHFADMLPELMGGSADLSPSNLTRHQKSVDFTGENPAGNYISYGVREFGMSAIMNG
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LALHGGFIPYGGTFLMFMEYARNALRMAALMKIRSVFVYTHDTIGLGEDGPTHQPVEQLA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHH
SLRLTPNMETWRGCDQVEVAVAWQQAIERKDGPTSLVLTRQPLAQQPRTAAQLAEIARGG
HEECCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCC
YVLSDCDGQPEMILISAGSEIELVVSAAKALTEEGRKVRVVSMPCTERFDNQDAAYKESV
EEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCHHHHHHH
LPKAVRKRLAVEASIAGFWERYVGLDGKVIGMTSFGESAPANVLFKHFGVTPENVLAQAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHH
ELLNS
HHHCC
>Mature Secondary Structure
MNLQLLANAIRMLSVDAIQKANSGHPGAPMGMADIAEVVWRRHLRHNPKNPQWFNRDRYV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
QSNGHGSMLIYALLHLTGYDLSMDDIRDFRQLHSRTPGHPEYGYTPGVETTTGPLGQGVA
ECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
NAVGMAIAEKALAAEFNKPGFNIVDHHTWLFLGDGCLMEGISHEACGLAGTLKLGNLIAI
HHHHHHHHHHHHHHHCCCCCCCEECCCEEEEECCCHHHHCCCCHHCCCEEEEECCCEEEE
WDDNGISIDGHVEGWFAEDTAARFRAYGWHVIEGVDGHDPEAVDAAVREAKSVTDKPSLL
ECCCCEEECCCCCCEECHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCHHH
CCKTIIGFGSPNKANSHDCHGSALGADEVALVRERLQWPYAPFEIPGEIYAEWDATEKGA
HHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHEEECCCCCCHH
QVQQEWDALFADYAKQWPELAAEFTRRMKGDLPAGWAENMQKYVHDLQSHPAALATRQVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
QKCLNHFADMLPELMGGSADLSPSNLTRHQKSVDFTGENPAGNYISYGVREFGMSAIMNG
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LALHGGFIPYGGTFLMFMEYARNALRMAALMKIRSVFVYTHDTIGLGEDGPTHQPVEQLA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHH
SLRLTPNMETWRGCDQVEVAVAWQQAIERKDGPTSLVLTRQPLAQQPRTAAQLAEIARGG
HEECCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHCCCHHHHHHHHHHHCC
YVLSDCDGQPEMILISAGSEIELVVSAAKALTEEGRKVRVVSMPCTERFDNQDAAYKESV
EEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHCCCCCHHHHHHH
LPKAVRKRLAVEASIAGFWERYVGLDGKVIGMTSFGESAPANVLFKHFGVTPENVLAQAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHH
ELLNS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]