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The map label for this gene is aslA [H]

Identifier: 218692077

GI number: 218692077

Start: 4420212

End: 4421867

Strand: Reverse

Name: aslA [H]

Synonym: ECED1_4484

Alternate gene names: 218692077

Gene position: 4421867-4420212 (Counterclockwise)

Preceding gene: 218692078

Following gene: 218692059

Centisome position: 84.88

GC content: 52.72

Gene sequence:

>1656_bases
ATGGAATTTTCGTTTTCACCCAAACTTCTTGTTGTTGCTGTCGCCGCAGCTCTTCCTCTCATAGCCAGCGCAGCAGATAC
CCCGTCAACCGCCACCGCACGCAAAGGCTTTGCCGGATACGATCACCCAAACCAGTATCTGGTTAAACCGGCGACCACTA
TTGCCGACAACATGATGCCGGTGATGCAGCATCCTGCACAAGACAAAGAAACCCAGCAGAAACTGGCGGAACTTGAGAAA
AAAACCGGTAAGAAACCGAACGTGGTTGTTTTCTTGCTGGATGATGTGGGCTGGATGGACGTTGGCTTTAACGGCGGCGG
CGTGGCGGTGGGTAACCCTACACCAGATATCGACGCCGTTGCCAGCCAGGGGCTGATTTTAACTTCGGCGTATTCTCAAC
CGAGTTCTTCCCCAACCCGCGCCACGATTCTCACCGGACAATACTCCATCCACCACGGCATTCTGATGCCGCCAATGTAC
GGGCAACCGGGCGGTCTGCAAGGGTTAACCACGCTGCCGCAGTTGCTGCACGATCAGGGCTACATCACCCAGGCTATCGG
GAAATGGCATATGGGGGAAAACAAAGAGTCGCAGCCGCAGAACGTTGGCTTTGATGATTTCCGCGGCTTTAACTCGGTGT
CCGATATGTATACCGAATGGCGTGATGTTCATGTCAACCCGGAAGTCGCCCTGAGCCCGGCTCGTTCTGAATACATCCAA
AAACTGCCGTTCAGCAAAGATGACGTTCATGCCGTGCACGGTGGTGAACAGGAAGCCATTGCCGACATTACGCCGAAATA
TATGGAAGACCTGGATCAACACTGGATGGAATATGGCGTTAAGTTCCTCGACAAGATGGCGAAGAGTGATAAGCCTTTCT
TCCTCTATTACGGCACTCGCGGCTGTCACTTCGATAACTACCCGAACGCCAAATATGCGGGTAGCTCTCCGGCGCGCACC
TCTTACGGCGACTGCATGGTGGAGATGAACGATATCTTCGCCAATCTGTATAAAGCACTGGAGAAAAACGGTCAGCTTGA
TAACACGCTGATTGTGTTCACCTCTGATAACGGTCCGGAAGCCGAAGTTCCGCCGCACGGTCGCACGCCGTTCCGCGGTG
CGAAAGGTTCTACATGGGAAGGCGGCGTTCGTGTGCCAACCTTCGTTTACTGGAAAGGCATGATCCAACCGCGTAAATCT
GACGGCATTGTCGATCTGGCGGATCTCTTCCCTACGGCGCTGGATCTGGCGGGGCATCCTGGGGCGAAAGTAGCGAATTT
AGTACCGAAAACCACCTTTATCGATGGTGTGGACCAGACATCTTTCTTCCTGGGAACAAATGGTCAGTCTAACCGTAAGG
CCGAGCATTACTTCCTCAACGGTAAACTTTCTGCTGTGCGTATGGATGAGTTCAAGTATCACGTCCTGATTCAGCAACCT
TACGCTTATACCCAGAGCGGATATCAGGGTGGATTCACCGGCACAGTAATGCAAACGGCGGGATCGTCGGTGTTTAACCT
GTACACCGATCCGCAGGAAAGCGACTCTATCGGCGTGCGCCATATCCCAATGGGTGTACCGCTACAGACCGAAATGCATG
CGTATATGGAGATCCTGAAAAAATATCCACCACGCGCGCAGATTAAATCTGATTAA

Upstream 100 bases:

>100_bases
TCACTATTATTTATGCAATCATCCTGTCAGGGAGAGGGATCTCAATTATCAATGCTTAATTACGTCATCATTTTGACGAC
ATGAAACCGGAGCATTTTGC

Downstream 100 bases:

>100_bases
GCCGGCGCTATCGCTGAGATCTACCTTTGCCGGATGCGATGCTGACGCATCCGACAATCAACCGCAGGCGGCCACAAAAT
GGCTGCTTTTTTACTTATTC

Product: arylsulfatase-like enzyme

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MEFSFSPKLLVVAVAAALPLIASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMPVMQHPAQDKETQQKLAELEK
KTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAVASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMY
GQPGGLQGLTTLPQLLHDQGYITQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPARSEYIQ
KLPFSKDDVHAVHGGEQEAIADITPKYMEDLDQHWMEYGVKFLDKMAKSDKPFFLYYGTRGCHFDNYPNAKYAGSSPART
SYGDCMVEMNDIFANLYKALEKNGQLDNTLIVFTSDNGPEAEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKS
DGIVDLADLFPTALDLAGHPGAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLSAVRMDEFKYHVLIQQP
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILKKYPPRAQIKSD

Sequences:

>Translated_551_residues
MEFSFSPKLLVVAVAAALPLIASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMPVMQHPAQDKETQQKLAELEK
KTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAVASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMY
GQPGGLQGLTTLPQLLHDQGYITQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPARSEYIQ
KLPFSKDDVHAVHGGEQEAIADITPKYMEDLDQHWMEYGVKFLDKMAKSDKPFFLYYGTRGCHFDNYPNAKYAGSSPART
SYGDCMVEMNDIFANLYKALEKNGQLDNTLIVFTSDNGPEAEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKS
DGIVDLADLFPTALDLAGHPGAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLSAVRMDEFKYHVLIQQP
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILKKYPPRAQIKSD
>Mature_551_residues
MEFSFSPKLLVVAVAAALPLIASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMPVMQHPAQDKETQQKLAELEK
KTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAVASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMY
GQPGGLQGLTTLPQLLHDQGYITQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPARSEYIQ
KLPFSKDDVHAVHGGEQEAIADITPKYMEDLDQHWMEYGVKFLDKMAKSDKPFFLYYGTRGCHFDNYPNAKYAGSSPART
SYGDCMVEMNDIFANLYKALEKNGQLDNTLIVFTSDNGPEAEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKS
DGIVDLADLFPTALDLAGHPGAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLSAVRMDEFKYHVLIQQP
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILKKYPPRAQIKSD

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=409, Percent_Identity=29.0953545232274, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI146229329, Length=409, Percent_Identity=29.0953545232274, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI6005990, Length=409, Percent_Identity=29.0953545232274, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI146229324, Length=409, Percent_Identity=29.0953545232274, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI45430057, Length=483, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI4503899, Length=405, Percent_Identity=28.3950617283951, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI38569407, Length=350, Percent_Identity=30.8571428571429, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI38569405, Length=350, Percent_Identity=30.8571428571429, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI146229327, Length=318, Percent_Identity=27.9874213836478, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI59797060, Length=347, Percent_Identity=31.1239193083574, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI109389362, Length=356, Percent_Identity=29.2134831460674, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI157266309, Length=449, Percent_Identity=27.8396436525612, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI31742482, Length=519, Percent_Identity=26.3969171483622, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI71852584, Length=520, Percent_Identity=26.1538461538462, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI58743319, Length=502, Percent_Identity=24.9003984063745, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI53831991, Length=273, Percent_Identity=27.4725274725275, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI71852586, Length=150, Percent_Identity=35.3333333333333, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1790233, Length=551, Percent_Identity=97.6406533575318, Blast_Score=1124, Evalue=0.0,
Organism=Escherichia coli, GI87081924, Length=417, Percent_Identity=26.6187050359712, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115533416, Length=482, Percent_Identity=23.8589211618257, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115533418, Length=474, Percent_Identity=23.4177215189873, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17559078, Length=267, Percent_Identity=24.3445692883895, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281363223, Length=368, Percent_Identity=30.1630434782609, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24666175, Length=409, Percent_Identity=29.3398533007335, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24666109, Length=427, Percent_Identity=25.7611241217799, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI281366397, Length=370, Percent_Identity=27.2972972972973, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281366395, Length=370, Percent_Identity=27.2972972972973, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24666163, Length=370, Percent_Identity=27.2972972972973, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 60604; Mature: 60604

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSFSPKLLVVAVAAALPLIASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMP
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEECCHHHHHHCCHH
VMQHPAQDKETQQKLAELEKKTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAV
HHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCEECCCCCCCHHHH
ASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMYGQPGGLQGLTTLPQLLHDQG
HCCCEEEEECCCCCCCCCCEEEEEECCEEECCCEECCCCCCCCCCCCHHHHHHHHHHCCC
YITQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPARSEYIQ
HHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHEEECCCCEEECCHHHHHHH
KLPFSKDDVHAVHGGEQEAIADITPKYMEDLDQHWMEYGVKFLDKMAKSDKPFFLYYGTR
HCCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
GCHFDNYPNAKYAGSSPARTSYGDCMVEMNDIFANLYKALEKNGQLDNTLIVFTSDNGPE
CCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
AEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKSDGIVDLADLFPTALDLAGHP
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHHHHCCCC
GAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLSAVRMDEFKYHVLIQQP
CCHHHHHCCCCCEECCCCCCEEEEECCCCCCCCCCEEEECCEEEEEEECCEEEEEEEECC
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILK
CHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
KYPPRAQIKSD
HCCCCCCCCCC
>Mature Secondary Structure
MEFSFSPKLLVVAVAAALPLIASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMP
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEECCHHHHHHCCHH
VMQHPAQDKETQQKLAELEKKTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAV
HHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCEECCCCCCCHHHH
ASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMYGQPGGLQGLTTLPQLLHDQG
HCCCEEEEECCCCCCCCCCEEEEEECCEEECCCEECCCCCCCCCCCCHHHHHHHHHHCCC
YITQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPARSEYIQ
HHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHEEECCCCEEECCHHHHHHH
KLPFSKDDVHAVHGGEQEAIADITPKYMEDLDQHWMEYGVKFLDKMAKSDKPFFLYYGTR
HCCCCCCCEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
GCHFDNYPNAKYAGSSPARTSYGDCMVEMNDIFANLYKALEKNGQLDNTLIVFTSDNGPE
CCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
AEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKSDGIVDLADLFPTALDLAGHP
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHHHHCCCC
GAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLSAVRMDEFKYHVLIQQP
CCHHHHHCCCCCEECCCCCCEEEEECCCCCCCCCCEEEECCEEEEEEECCEEEEEEEECC
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILK
CHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
KYPPRAQIKSD
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]