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The map label for this gene is hemN [C]

Identifier: 218691787

GI number: 218691787

Start: 4087412

End: 4088749

Strand: Direct

Name: hemN [C]

Synonym: ECED1_4181

Alternate gene names: 218691787

Gene position: 4087412-4088749 (Clockwise)

Preceding gene: 218691786

Following gene: 218691788

Centisome position: 78.46

GC content: 52.54

Gene sequence:

>1338_bases
ATGAACACAAATAACACCCTGGATCTCACGCCACATTTTGCTTTAGACGGTGATCAGCCCTTTAAAGACAGGCGCGCCAT
GATGCCGTTTCGTGGGGCCATTCCGGTTGCCAAAGAGCAACTGGCACAGACCTGGCAAGAGATGATCAATCAAACGGTAT
CACCACGTAAGCGACTGGTTTACCTACACATTCCTTTTTGTGCGACACACTGCACGTTTTGTGGTTTTTATCAGAACCGT
TTTAATGAAGATGCGTGTGCTCATTATACCGACGCCCTGATTCGTGAAATAGAACGGGAAGCAGACAGCGTATTGCATCA
GTCGGCCCCCATCCACGCGGTCTATTTCGGTGGCGGTACGCCTTCCGCGCTTTCGGCACACGATTTGGCCAGAATCATCA
CCACATTACGAGAAAAGCTGCCACTGGCCCCTGATTGTGAAATCACTATCGAAGGCCGGGTACTGAATTTTGACGCTGAG
CGAATCGATGCTTGCCTTGATGCTGGAGCAAACCGCTTCTCAATTGGTATTCAGTCGTTTAACAGCAAAATCCGCAAGAA
AATGGCCCGCACCTCGGATGGCCCAACCGCTATTGCGTTTATGGAAAGCCTGGTCAAACGCGACCGTGCCGCGGTGGTCT
GTGACCTGCTGTTTGGTCTGCCGGGTCAGGATGCGCAAACCTGGGGAGAAGATCTGGCTATTGCCCGCGATATCGGTCTC
GACGGCGTCGATCTCTATGCGCTCAATGTCCTGCCCAATACACCGCTGGGCAAAGCCGTGGAAAATGGGCGTACTACCGT
GCCCTCTCCGGCAGAACGTCGCGATCTTTACCTGCAAGGGTGTGATTTTATGGACGATGCCGGTTGGCGCTGCATCAGTA
ACAGCCACTGGGGCCGTACCACACGCGAACGCAATCTCTATAACCTGCTGATTAAACAAGGTGCCGATTGTCTGGCCTTT
GGTTCCGGAGCCGGCGGTTCGATTAATGGTTACTCCTGGATGAACGAACGCAATCTTCAGACCTGGCATGAATCCGTCGC
AGCAGGTAAAAAACCGCTGATGATGATCATGCGTAACGCCGAACGTAACGCGCAGTGGCGTCATACCTTGCAGTCGGGCA
TTGAAACGGCGCGTGTACCGCTGGACGAACTTACGCCACATGCCGAAAAACTCGCGCCGTTACTGGCCCAGTGGCACCAA
AAAGGCTTAAGCCGCGATGCGTCAACGTGTCTGCGGTTGACCAATGAAGGTCGTTTCTGGGCAAGCAACATTTTGCAGTC
TCTTAATGAACTGATTCAGGTACTTAATGCGCCAGCAATTGCGCTTGAAAAACCATAA

Upstream 100 bases:

>100_bases
GATCAAAACCTGATTCTGGGAATGGGTCCGCGTATTGCTGATGTCGTTGAGTCTTTACACCAGCAGCTTTGGCCGCAATA
AATGGATTTAAATCAGACGA

Downstream 100 bases:

>100_bases
CAGGAGTGATTTATGAGCCATGTCTCGTTACAGGAATTTTTGAAAACGGAGCCAGACGGTACGCTGGAGGCGATCGCCGA
ACAATACAACACCACGCTGC

Product: coproporphyrinogen III oxidase

Products: Protoporphyrinogen IX; CO2; H2O

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNTNNTLDLTPHFALDGDQPFKDRRAMMPFRGAIPVAKEQLAQTWQEMINQTVSPRKRLVYLHIPFCATHCTFCGFYQNR
FNEDACAHYTDALIREIEREADSVLHQSAPIHAVYFGGGTPSALSAHDLARIITTLREKLPLAPDCEITIEGRVLNFDAE
RIDACLDAGANRFSIGIQSFNSKIRKKMARTSDGPTAIAFMESLVKRDRAAVVCDLLFGLPGQDAQTWGEDLAIARDIGL
DGVDLYALNVLPNTPLGKAVENGRTTVPSPAERRDLYLQGCDFMDDAGWRCISNSHWGRTTRERNLYNLLIKQGADCLAF
GSGAGGSINGYSWMNERNLQTWHESVAAGKKPLMMIMRNAERNAQWRHTLQSGIETARVPLDELTPHAEKLAPLLAQWHQ
KGLSRDASTCLRLTNEGRFWASNILQSLNELIQVLNAPAIALEKP

Sequences:

>Translated_445_residues
MNTNNTLDLTPHFALDGDQPFKDRRAMMPFRGAIPVAKEQLAQTWQEMINQTVSPRKRLVYLHIPFCATHCTFCGFYQNR
FNEDACAHYTDALIREIEREADSVLHQSAPIHAVYFGGGTPSALSAHDLARIITTLREKLPLAPDCEITIEGRVLNFDAE
RIDACLDAGANRFSIGIQSFNSKIRKKMARTSDGPTAIAFMESLVKRDRAAVVCDLLFGLPGQDAQTWGEDLAIARDIGL
DGVDLYALNVLPNTPLGKAVENGRTTVPSPAERRDLYLQGCDFMDDAGWRCISNSHWGRTTRERNLYNLLIKQGADCLAF
GSGAGGSINGYSWMNERNLQTWHESVAAGKKPLMMIMRNAERNAQWRHTLQSGIETARVPLDELTPHAEKLAPLLAQWHQ
KGLSRDASTCLRLTNEGRFWASNILQSLNELIQVLNAPAIALEKP
>Mature_445_residues
MNTNNTLDLTPHFALDGDQPFKDRRAMMPFRGAIPVAKEQLAQTWQEMINQTVSPRKRLVYLHIPFCATHCTFCGFYQNR
FNEDACAHYTDALIREIEREADSVLHQSAPIHAVYFGGGTPSALSAHDLARIITTLREKLPLAPDCEITIEGRVLNFDAE
RIDACLDAGANRFSIGIQSFNSKIRKKMARTSDGPTAIAFMESLVKRDRAAVVCDLLFGLPGQDAQTWGEDLAIARDIGL
DGVDLYALNVLPNTPLGKAVENGRTTVPSPAERRDLYLQGCDFMDDAGWRCISNSHWGRTTRERNLYNLLIKQGADCLAF
GSGAGGSINGYSWMNERNLQTWHESVAAGKKPLMMIMRNAERNAQWRHTLQSGIETARVPLDELTPHAEKLAPLLAQWHQ
KGLSRDASTCLRLTNEGRFWASNILQSLNELIQVLNAPAIALEKP

Specific function: Anaerobic Transformation Of Coproporphyrinogen-III Into Protoporphyrinogen-IX. [C]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=275, Percent_Identity=28.3636363636364, Blast_Score=107, Evalue=3e-23,
Organism=Escherichia coli, GI87082341, Length=387, Percent_Identity=24.031007751938, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789325, Length=271, Percent_Identity=27.6752767527675, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: 1.3.3.3

Molecular weight: Translated: 49572; Mature: 49572

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNNTLDLTPHFALDGDQPFKDRRAMMPFRGAIPVAKEQLAQTWQEMINQTVSPRKRLV
CCCCCCEECCCCEECCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEE
YLHIPFCATHCTFCGFYQNRFNEDACAHYTDALIREIEREADSVLHQSAPIHAVYFGGGT
EEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PSALSAHDLARIITTLREKLPLAPDCEITIEGRVLNFDAERIDACLDAGANRFSIGIQSF
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEEECCHHHHHHHHHCCCCEEEHHHHHH
NSKIRKKMARTSDGPTAIAFMESLVKRDRAAVVCDLLFGLPGQDAQTWGEDLAIARDIGL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
DGVDLYALNVLPNTPLGKAVENGRTTVPSPAERRDLYLQGCDFMDDAGWRCISNSHWGRT
CCEEEEEEECCCCCCCCHHHHCCCCCCCCCHHHCCEEEECCCCCCCCCCEEECCCCCCCC
TRERNLYNLLIKQGADCLAFGSGAGGSINGYSWMNERNLQTWHESVAAGKKPLMMIMRNA
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCC
ERNAQWRHTLQSGIETARVPLDELTPHAEKLAPLLAQWHQKGLSRDASTCLRLTNEGRFW
CCCHHHHHHHHHCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHH
ASNILQSLNELIQVLNAPAIALEKP
HHHHHHHHHHHHHHHCCCCEECCCC
>Mature Secondary Structure
MNTNNTLDLTPHFALDGDQPFKDRRAMMPFRGAIPVAKEQLAQTWQEMINQTVSPRKRLV
CCCCCCEECCCCEECCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEE
YLHIPFCATHCTFCGFYQNRFNEDACAHYTDALIREIEREADSVLHQSAPIHAVYFGGGT
EEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCC
PSALSAHDLARIITTLREKLPLAPDCEITIEGRVLNFDAERIDACLDAGANRFSIGIQSF
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECEEEECCHHHHHHHHHCCCCEEEHHHHHH
NSKIRKKMARTSDGPTAIAFMESLVKRDRAAVVCDLLFGLPGQDAQTWGEDLAIARDIGL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
DGVDLYALNVLPNTPLGKAVENGRTTVPSPAERRDLYLQGCDFMDDAGWRCISNSHWGRT
CCEEEEEEECCCCCCCCHHHHCCCCCCCCCHHHCCEEEECCCCCCCCCCEEECCCCCCCC
TRERNLYNLLIKQGADCLAFGSGAGGSINGYSWMNERNLQTWHESVAAGKKPLMMIMRNA
HHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCC
ERNAQWRHTLQSGIETARVPLDELTPHAEKLAPLLAQWHQKGLSRDASTCLRLTNEGRFW
CCCHHHHHHHHHCHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHH
ASNILQSLNELIQVLNAPAIALEKP
HHHHHHHHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coproporphyrinogen III; O2; H+

Specific reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]