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The map label for this gene is ggt [H]

Identifier: 218691732

GI number: 218691732

Start: 4027212

End: 4028972

Strand: Reverse

Name: ggt [H]

Synonym: ECED1_4120

Alternate gene names: 218691732

Gene position: 4028972-4027212 (Counterclockwise)

Preceding gene: 218691734

Following gene: 218691728

Centisome position: 77.34

GC content: 53.66

Gene sequence:

>1761_bases
TTGCCCCTTAATCTCTGGAGAATAACGATGATAAAACCGACGTTTTTACGCCGGGTGGCCATTGCTGCTCTGCTCACAGG
AAGTTGTTTTAGTACGGTAGCCGCGCCACCTGTTTCTTATGGTGTGGAGGAAGATGTCTTCCATCCGGTACGCGCTAAGC
AGGGAATGGTGGCGTCTGTAGATGCTACTGCCACTCAGGTGGGGGTGGATATCCTCAAGGAGGGCGGGAATGCCGTTGAT
GCTGCCGTGGCGGTGGGCTACGCGCTGGCAGTAACGCATCCGCAGGCAGGGAATCTGGGCGGCGGTGGTTTTATGCTGAT
CCGCTCGAAAAATGGCAATACCACGGCTATCGATTTCCGCGAAATGGCACCCGCCAAAGCGACCCGCGATATGTTCCTCG
ATGATCAGGGCAACCCGGACAGCAACAAATCACTCACTTCGCATCTGGCTTCCGGCACACCCGGTACGGTAGCGGGTTTC
TCGTTGGCGCTGGATAAATACGGCACCATGCCGTTGAATAAAGTGGTGCAACCGGCGTTTAAACTGGCACGCGATGGTTT
TATCGTTAACGACGCGCTGGCTGACGATCTCAAAACCTACGGCAGTGAAGTGCTGCCGAACCACGAAAACAGCAAAGCTA
TCTTCTGGAAAGAGGGCGAACCGCTGAAAAAGGGCGACAAGCTGGTGCAGGCGAACCTGGCAAAGAGCCTGGAGATGATT
GCCGAAAACGGCCCGGATGAATTCTACAAAGGCACGATAGCGGAACAGATTGCCCAGGAGATGCAGAAAAACGGTGGCTT
GATCAGCAAAGAAGATTTAGCGGCATATAAAGCGGTCGAACGCACACCGATAAGCGGCGATTATCGCGGGTATCAGGTTT
ACTCCATGCCACCGCCATCTTCCGGCGGTATTCATATCGTACAAATCCTCAATATTCTGGAAAACTTCGATATGCAGAAG
TACGGCTTTGGCAGCGCCGACGCGATGCAAATCATGGCAGAAGCTGAGAAATACGCCTATGCCGGCCGCTCGGAATATCT
TGGCGACCCGGATTTTGTCAAAGTACCGTGGCAGGTGCTGACCAATAAAGCCTATGCCAAATCTATTGCCGATCAAATCG
ATATCAATAAAGCGAAGCCATCCAGCGAAATTCGTCCTGGCAAGCTTGCGCCTTATGAGAGTAATCAAACTACCCATTAC
TCAGTAGTGGATAAAGACGGTAACGCCGTGGCGGTGACCTATACGCTGAACACCACCTTCGGTACGGGCATTGTCGCGGG
CGAGAGCGGTATTTTGCTCAATAACCAGATGGATGATTTCTCCGCCAAACCAGGCGTACCGAACGTTTACGGGCTGGTGG
GCGGCGATGCCAACGCCGTCGGGCCGAATAAACGCCCTCTGTCGTCGATGTCACCAACCATTGTGGTCAAGGATGGTAAA
ACCTGGCTGGTCACCGGAAGCCCAGGCGGTAGCCGGATTATCACCACTGTGCTGCAAATGGTGGTGAATAGCATCGATTA
TGGAATGAACGTCGCCGAAGCGACCAATGCGCCACGTTTCCACCATCAGTGGTTGCCGGACGAGCTGCGTGTCGAAAAAG
GGTTTAGCCCGGATACGATCAAGCTGCTGGAAGCAAAAGGTCAGAAAGTGGCGCTGAAAGAGGCGATGGGCAGTACACAA
AGCATTATGGTTGGGCCGGACGGTGAGCTGTACGGTGCATCCGACCCGCGCTCGGTGGATGATTTAACGGCGGGGTATTA
A

Upstream 100 bases:

>100_bases
CGTTTCATCGCGTATCCTCCTCTGAAGATATTCTTTAAGTTTACTCGCTTCCCGGCAAAACGATGATTAATTCAGAGTTA
TATACCAGGCTTAGCTGGGG

Downstream 100 bases:

>100_bases
GGTTAGCGGCCCTCTTCGTGGGAAGAGGGCCGTATTGTCAGGGCAAGCCGAAGGTAGCCTTTTTTATTTCATAATCCTGT
AGATATTCTTCCAGCGGCTT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MPLNLWRITMIKPTFLRRVAIAALLTGSCFSTVAAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVD
AAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSNKSLTSHLASGTPGTVAGF
SLALDKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMI
AENGPDEFYKGTIAEQIAQEMQKNGGLISKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMQK
YGFGSADAMQIMAEAEKYAYAGRSEYLGDPDFVKVPWQVLTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHY
SVVDKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGK
TWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTIKLLEAKGQKVALKEAMGSTQ
SIMVGPDGELYGASDPRSVDDLTAGY

Sequences:

>Translated_586_residues
MPLNLWRITMIKPTFLRRVAIAALLTGSCFSTVAAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVD
AAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSNKSLTSHLASGTPGTVAGF
SLALDKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMI
AENGPDEFYKGTIAEQIAQEMQKNGGLISKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMQK
YGFGSADAMQIMAEAEKYAYAGRSEYLGDPDFVKVPWQVLTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHY
SVVDKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGK
TWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTIKLLEAKGQKVALKEAMGSTQ
SIMVGPDGELYGASDPRSVDDLTAGY
>Mature_585_residues
PLNLWRITMIKPTFLRRVAIAALLTGSCFSTVAAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDA
AVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSNKSLTSHLASGTPGTVAGFS
LALDKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIA
ENGPDEFYKGTIAEQIAQEMQKNGGLISKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMQKY
GFGSADAMQIMAEAEKYAYAGRSEYLGDPDFVKVPWQVLTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYS
VVDKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKT
WLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTIKLLEAKGQKVALKEAMGSTQS
IMVGPDGELYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=533, Percent_Identity=32.2701688555347, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915090, Length=533, Percent_Identity=32.2701688555347, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915096, Length=533, Percent_Identity=32.2701688555347, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI73915094, Length=533, Percent_Identity=32.2701688555347, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI113429324, Length=521, Percent_Identity=31.6698656429942, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI113429326, Length=530, Percent_Identity=30.9433962264151, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI109148539, Length=583, Percent_Identity=31.0463121783877, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI153266901, Length=550, Percent_Identity=28.3636363636364, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI153266885, Length=551, Percent_Identity=28.3121597096189, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI153266907, Length=547, Percent_Identity=26.8738574040219, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=33.7899543378995, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=33.7899543378995, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=32.4200913242009, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=30.5936073059361, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789856, Length=580, Percent_Identity=97.5862068965517, Blast_Score=1146, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72000294, Length=573, Percent_Identity=34.0314136125654, Blast_Score=261, Evalue=9e-70,
Organism=Caenorhabditis elegans, GI212646519, Length=573, Percent_Identity=34.0314136125654, Blast_Score=261, Evalue=9e-70,
Organism=Caenorhabditis elegans, GI193208245, Length=561, Percent_Identity=32.7985739750446, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI193208247, Length=561, Percent_Identity=33.1550802139037, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17506189, Length=557, Percent_Identity=31.0592459605027, Blast_Score=242, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=499, Percent_Identity=35.4709418837675, Blast_Score=238, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.5395033860045, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI72001497, Length=233, Percent_Identity=27.4678111587983, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=232, Percent_Identity=26.2931034482759, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=491, Percent_Identity=29.3279022403259, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI161077878, Length=516, Percent_Identity=33.5271317829457, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI45551474, Length=516, Percent_Identity=33.5271317829457, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI161077880, Length=516, Percent_Identity=33.5271317829457, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24642670, Length=516, Percent_Identity=33.5271317829457, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24642666, Length=516, Percent_Identity=33.5271317829457, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=30.9160305343511, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.6949806949807, Blast_Score=225, Evalue=8e-59,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=28.3121597096189, Blast_Score=189, Evalue=7e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62688; Mature: 62557

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNLWRITMIKPTFLRRVAIAALLTGSCFSTVAAPPVSYGVEEDVFHPVRAKQGMVASV
CCCCEEEEEEECHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHCCCHHHCCCCEEEC
DATATQVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFR
CCHHHHHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHH
EMAPAKATRDMFLDDQGNPDSNKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAF
HCCCCHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
KLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMI
HHHHCCEEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
AENGPDEFYKGTIAEQIAQEMQKNGGLISKEDLAAYKAVERTPISGDYRGYQVYSMPPPS
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
SGGIHIVQILNILENFDMQKYGFGSADAMQIMAEAEKYAYAGRSEYLGDPDFVKVPWQVL
CCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCEEECCHHHH
TNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTF
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCC
GTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGK
CCEEEECCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCC
TWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTI
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCCHH
KLLEAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
HHHHCCCCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC
>Mature Secondary Structure 
PLNLWRITMIKPTFLRRVAIAALLTGSCFSTVAAPPVSYGVEEDVFHPVRAKQGMVASV
CCCEEEEEEECHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHCCCHHHCCCCEEEC
DATATQVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFR
CCHHHHHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHH
EMAPAKATRDMFLDDQGNPDSNKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAF
HCCCCHHHHHHEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
KLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMI
HHHHCCEEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
AENGPDEFYKGTIAEQIAQEMQKNGGLISKEDLAAYKAVERTPISGDYRGYQVYSMPPPS
HCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
SGGIHIVQILNILENFDMQKYGFGSADAMQIMAEAEKYAYAGRSEYLGDPDFVKVPWQVL
CCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCEEECCHHHH
TNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTF
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCC
GTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGK
CCEEEECCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCC
TWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTI
EEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCCHH
KLLEAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
HHHHCCCCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]