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The map label for this gene is gntU [H]

Identifier: 218691724

GI number: 218691724

Start: 4018758

End: 4020098

Strand: Reverse

Name: gntU [H]

Synonym: ECED1_4110

Alternate gene names: 218691724

Gene position: 4020098-4018758 (Counterclockwise)

Preceding gene: 218691725

Following gene: 218691722

Centisome position: 77.17

GC content: 55.26

Gene sequence:

>1341_bases
GTGACTACATTAACGCTTGTTTTAACAGCAGTAGGGTCTGTTTTACTGCTGCTGTTTTTAGTCATGAAGGCGCGTATGCA
CGCTTTCCTGGCTTTAATGGTGGTGTCCATGGGGGCTGGCCTTTTTTCTGGTATGCCGCTCGATAAAATCGCAGCGACGA
TGGAAAAAGGGATGGGAGGCACCCTCGGCTTCCTGGCGGTGGTTGTCGCCCTGGGAGCCATGTTTGGTAAGATCTTACAT
GAAACCGGCGCGGTCGATCAGATTGCCGTCAAAATGCTCAAATCCTTCGGTCACAGCCGCGTGCATTATGCTATCGGCCT
TGCGGGGCTGGTTTGTGCGCTACCGCTGTTCTTTGAAGTGGCGATTGTTCTGCTGATTAGCGTTGCTTTCTCAATGGCGC
GCCACACCGGCACGAACCTGGTGAAGCTGGTAATCCCATTATTTGCAGGCGTGGCGGCAGCGGCTGCGTTCCTGGTGCCT
GGGCCAGCGCCAATGCTGCTGGCATCGCAGATGAACGCCGACTTTGGCTGGATGATCCTGATTGGCCTGTGCGCGGCAAT
TCCGGGAATGATTATTGCCGGGCCGCTGTGGGGTAATTTCATCAGCCGCTACGTGGAGTTGCATATTCCTGACGACATCA
GCGAACCGCATCTCGGCGAAGGCAAAATGCCGTCCTTCGGATTCAGCCTGTCGCTGATCCTGTTGCCACTGGTGCTGGTG
GGGCTGAAAACCATTGCCGCGCGTTTTGTGCCAGAAGGCTCTACTGCTTACGAATGGTTCGAGTTTATTGGTCATCCGTT
TACCGCGATTCTGGTTGCTTGCCTGGTGGCGATTTACGGTCTGGCAATGCGTCAGGGTATGCCAAAAGACAAAGTGATGG
AGATTTGCGGTCACGCGCTGCAACCGGCGGGGATCATTCTGCTGGTGATTGGTGCGGGCGGCGTGTTCAAACAGGTGCTG
GTTGACTCTGGTGTCGGTCCGGCACTGGGCGAAGCGTTAACCGGCATGGGCCTGCCGATTGCCATCACCTGCTTCGTGCT
GGCAGCTGCAGTGCGCATCATTCAGGGTTCTGCTACCGTTGCCTGTTTAACGGCGGTGGGATTGGTAATGCCGGTCATTG
AACAACTGAACTACTCCGGTGCGCAAATGGCGGCGCTGTCGATTTGTATCGCCGGTGGTTCGATTGTTGTCAGCCACGTT
AACGACGCGGGTTTCTGGTTGTTCGGTAAATTTACCGGCGCGACCGAAGCCGAAACGCTTAAAACCTGGACCATGATGGA
AACCATCCTCGGCACTGTCGGTGCCATCGTTGGGATGATTGCGTTCCAGCTGTTGAGTTAA

Upstream 100 bases:

>100_bases
GGGTGCGGACGAAACCGATGTACTGGTGGTGGATATTGATCAACCGCTGGAAGGTGTTGTGGCAAGCACCATTGAGGTTA
TTAAAAAAGGCAAATAAGTA

Downstream 100 bases:

>100_bases
GTTTGTTTACCCGGTAGTTCTGACGCTACCGGGCTCTTTTCGAAAAACTCTCCTCGTTACCCCTTCATCCACATTCGAAT
GCCGTCGAGGAACATCTGAG

Product: low affinity gluconate transporter

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease; Gnt-I system [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MTTLTLVLTAVGSVLLLLFLVMKARMHAFLALMVVSMGAGLFSGMPLDKIAATMEKGMGGTLGFLAVVVALGAMFGKILH
ETGAVDQIAVKMLKSFGHSRVHYAIGLAGLVCALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLVP
GPAPMLLASQMNADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELHIPDDISEPHLGEGKMPSFGFSLSLILLPLVLV
GLKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHALQPAGIILLVIGAGGVFKQVL
VDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHV
NDAGFWLFGKFTGATEAETLKTWTMMETILGTVGAIVGMIAFQLLS

Sequences:

>Translated_446_residues
MTTLTLVLTAVGSVLLLLFLVMKARMHAFLALMVVSMGAGLFSGMPLDKIAATMEKGMGGTLGFLAVVVALGAMFGKILH
ETGAVDQIAVKMLKSFGHSRVHYAIGLAGLVCALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLVP
GPAPMLLASQMNADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELHIPDDISEPHLGEGKMPSFGFSLSLILLPLVLV
GLKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHALQPAGIILLVIGAGGVFKQVL
VDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHV
NDAGFWLFGKFTGATEAETLKTWTMMETILGTVGAIVGMIAFQLLS
>Mature_445_residues
TTLTLVLTAVGSVLLLLFLVMKARMHAFLALMVVSMGAGLFSGMPLDKIAATMEKGMGGTLGFLAVVVALGAMFGKILHE
TGAVDQIAVKMLKSFGHSRVHYAIGLAGLVCALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLVPG
PAPMLLASQMNADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELHIPDDISEPHLGEGKMPSFGFSLSLILLPLVLVG
LKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHALQPAGIILLVIGAGGVFKQVLV
DSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHVN
DAGFWLFGKFTGATEAETLKTWTMMETILGTVGAIVGMIAFQLLS

Specific function: Part of the gluconate utilization system Gnt-I; low- affinity intake of gluconate [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI48994939, Length=446, Percent_Identity=99.7757847533632, Blast_Score=872, Evalue=0.0,
Organism=Escherichia coli, GI1790716, Length=430, Percent_Identity=37.4418604651163, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI48994935, Length=434, Percent_Identity=36.405529953917, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI2367370, Length=429, Percent_Identity=33.5664335664336, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI1788707, Length=429, Percent_Identity=35.6643356643357, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1789097, Length=450, Percent_Identity=32.6666666666667, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1790776, Length=431, Percent_Identity=31.0904872389791, Blast_Score=206, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 46445; Mature: 46314

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTLTLVLTAVGSVLLLLFLVMKARMHAFLALMVVSMGAGLFSGMPLDKIAATMEKGMGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCC
TLGFLAVVVALGAMFGKILHETGAVDQIAVKMLKSFGHSRVHYAIGLAGLVCALPLFFEV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLVPGPAPMLLASQMNADFGWMIL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHH
IGLCAAIPGMIIAGPLWGNFISRYVELHIPDDISEPHLGEGKMPSFGFSLSLILLPLVLV
HHHHHHCCHHHEECHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GLKTIAARFVPEGSTAYEWFEFIGHPFTAILVACLVAIYGLAMRQGMPKDKVMEICGHAL
HHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
QPAGIILLVIGAGGVFKQVLVDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATV
CCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHH
ACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHVNDAGFWLFGKFTGATEAETL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCHHHH
KTWTMMETILGTVGAIVGMIAFQLLS
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]