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The map label for this gene is glpD [H]

Identifier: 218691701

GI number: 218691701

Start: 3993825

End: 3995330

Strand: Direct

Name: glpD [H]

Synonym: ECED1_4086

Alternate gene names: 218691701

Gene position: 3993825-3995330 (Clockwise)

Preceding gene: 218691697

Following gene: 218691711

Centisome position: 76.66

GC content: 54.78

Gene sequence:

>1506_bases
ATGGAAACCAAAGATCTGATTGTGATAGGTGGCGGCATCAATGGTGCTGGTATCGCGGCAGACGCCGCTGGACGCGGTTT
ATCCGTGCTGATGCTGGAGGCGCAGGATCTCGCTTGCGCGACCTCTTCCGCCAGTTCAAAACTCATTCACGGTGGCCTGC
GCTACCTTGAGCACTATGAATTCCGCCTGGTCAGCGAGGCGCTGGCTGAACGTGAAGTGCTACTGAAAATGGCCCCGCAT
ATCGCCTTCCCGATGCGTTTTCGCCTGCCGCATCGTCCGCATCTACGCCCGGCGTGGATGATTCGTATTGGTCTGTTTAT
GTACGATCATCTGGGTAAACGCACCAGCCTGCCGGGATCAACCGGTTTGCGTTTTGGCGCAAACTCAGTGTTAAAACCGG
AAATTATGCGCGGATTCGAATATTCTGACTGTTGGGTAGACGACGCCCGTCTGGTACTCGCCAACGCCCAGATGGTGGTG
CGTAAAGGCGGTGAAGTGCTTACTCGTACTCGTGCCACGTCTGCTCGCCGCGAAAAAGGCCTGTGGATTGTGGAAGCGGA
AGATATCGATACCGGCAAAAAATATACATGGCAGGCGCGCGGCCTGGTTAATGCTACCGGCCCGTGGGTGAAACAATTTT
TCGACGACGGGATGCATCTGCCTTCACCTTATGGCATTCGCCTGATCAAAGGCAGCCATATTGTGGTGCCGCGTGTGCAT
ACCCAGAAGCAAGCCTACATTCTGCAAAACGAAGATAAACGTATTGTCTTCGTGATCCCGTGGATGGACGAGTTTTCCAT
CATCGGCACCACCGATGTGGAATACAAAGGCGATCCAAAAGCAGTGAAGATTGAAGAGAGTGAAATCAATTACCTGTTGA
AAGTGTATAACACGCACTTTAAAAAGCAGTTAAACCGGGACGATATCGTCTGGACCTACTCCGGCGTGCGTCCGCTATGT
GATGATGAGTCCGACTCGCCACAGGCCATTACCCGTGATTACACCCTTGATATCCATGATGAAGACGGCAAAGCCCCGCT
GCTGTCGGTATTCGGCGGTAAGCTGACCACCTACCGCAAACTGGCGGAGCACGCGCTGGAAAAACTGACGCCATATTATC
AGGGCATTGGTCCGGCGTGGACGAAAGAGAGCGTGCTGCCGGGTGGTGCCATTGAAGGCGACCGTGACGATTACGCCGCC
CGCCTGCGCCGCCGTTACCCGTTCCTGACCGAATCGCTGGCACGTCACTACGCGCGCACTTACGGCAGCAACAGCGAACT
GTTGCTCGGCAATGCAGGGGCGATAAGCGACCTCGGTGAAAATTTCGGTCATGAGTTCTACGAAGCGGAGCTGAAATATC
TGGTCGACCACGAATGGGTCCGCCGCGCCGACGATGCCCTGTGGCGTCGCACGAAACAAGGCATGTGGCTAAATGCGGAT
CAACAATCTCGTGTGAGTCAGTGGCTGATGGAATATACGCAGCAGAGGTTGTCGCTGGCGTCGTAA

Upstream 100 bases:

>100_bases
ACTCTAAAATGTTTTTTCAATGTTACCCAAAGCGCGATTCTTTGCTAATATGTTCGATAACGAACATTTATGAACTTTAA
CGAAAGTGAATGAGGGCAGC

Downstream 100 bases:

>100_bases
GGATGATGCCCGGTTGCGAAGTGCAACCGGGCTATTTGAATTCCTTAGACTATTCATTGTAAATAATTGAATAACGGCCC
CAGAGCTAAAATCGCCAAAC

Product: glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPH
IAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIMRGFEYSDCWVDDARLVLANAQMVV
RKGGEVLTRTRATSARREKGLWIVEAEDIDTGKKYTWQARGLVNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVH
TQKQAYILQNEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNTHFKKQLNRDDIVWTYSGVRPLC
DDESDSPQAITRDYTLDIHDEDGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAA
RLRRRYPFLTESLARHYARTYGSNSELLLGNAGAISDLGENFGHEFYEAELKYLVDHEWVRRADDALWRRTKQGMWLNAD
QQSRVSQWLMEYTQQRLSLAS

Sequences:

>Translated_501_residues
METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPH
IAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIMRGFEYSDCWVDDARLVLANAQMVV
RKGGEVLTRTRATSARREKGLWIVEAEDIDTGKKYTWQARGLVNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVH
TQKQAYILQNEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNTHFKKQLNRDDIVWTYSGVRPLC
DDESDSPQAITRDYTLDIHDEDGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAA
RLRRRYPFLTESLARHYARTYGSNSELLLGNAGAISDLGENFGHEFYEAELKYLVDHEWVRRADDALWRRTKQGMWLNAD
QQSRVSQWLMEYTQQRLSLAS
>Mature_501_residues
METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYEFRLVSEALAEREVLLKMAPH
IAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIMRGFEYSDCWVDDARLVLANAQMVV
RKGGEVLTRTRATSARREKGLWIVEAEDIDTGKKYTWQARGLVNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVH
TQKQAYILQNEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNTHFKKQLNRDDIVWTYSGVRPLC
DDESDSPQAITRDYTLDIHDEDGKAPLLSVFGGKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAA
RLRRRYPFLTESLARHYARTYGSNSELLLGNAGAISDLGENFGHEFYEAELKYLVDHEWVRRADDALWRRTKQGMWLNAD
QQSRVSQWLMEYTQQRLSLAS

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=509, Percent_Identity=30.8447937131631, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI285002231, Length=509, Percent_Identity=30.8447937131631, Blast_Score=179, Evalue=7e-45,
Organism=Escherichia coli, GI2367226, Length=501, Percent_Identity=98.0039920159681, Blast_Score=1018, Evalue=0.0,
Organism=Escherichia coli, GI1788574, Length=385, Percent_Identity=26.2337662337662, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17509253, Length=513, Percent_Identity=28.8499025341131, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI115534726, Length=508, Percent_Identity=29.9212598425197, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6322036, Length=531, Percent_Identity=27.683615819209, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI161077125, Length=513, Percent_Identity=30.2144249512671, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24653942, Length=513, Percent_Identity=30.2144249512671, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24653944, Length=513, Percent_Identity=30.2144249512671, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI20130025, Length=513, Percent_Identity=30.2144249512671, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24586295, Length=502, Percent_Identity=27.0916334661355, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI19921278, Length=497, Percent_Identity=24.1448692152917, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 56839; Mature: 56839

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00977 FAD_G3PDH_1 ; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYE
CCCCCEEEECCCCCCCCEECCCCCCCEEEEEEECCHHHEECCCCCHHHHHHHHHHHHHHH
FRLVSEALAEREVLLKMAPHIAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGS
HHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
TGLRFGANSVLKPEIMRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTRTRATSARREKG
CCCCCCCCCCCCHHHHCCCCCCCCEECCCEEEEECCHHHHHCCCHHEEHHHHHHHHHHCC
LWIVEAEDIDTGKKYTWQARGLVNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVH
EEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCEEEEECCC
TQKQAYILQNEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNTHF
CCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
KKQLNRDDIVWTYSGVRPLCDDESDSPQAITRDYTLDIHDEDGKAPLLSVFGGKLTTYRK
HHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCHHHHCCCHHHHHH
LAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFLTESLARHYART
HHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
YGSNSELLLGNAGAISDLGENFGHEFYEAELKYLVDHEWVRRADDALWRRTKQGMWLNAD
CCCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
QQSRVSQWLMEYTQQRLSLAS
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
METKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGGLRYLEHYE
CCCCCEEEECCCCCCCCEECCCCCCCEEEEEEECCHHHEECCCCCHHHHHHHHHHHHHHH
FRLVSEALAEREVLLKMAPHIAFPMRFRLPHRPHLRPAWMIRIGLFMYDHLGKRTSLPGS
HHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
TGLRFGANSVLKPEIMRGFEYSDCWVDDARLVLANAQMVVRKGGEVLTRTRATSARREKG
CCCCCCCCCCCCHHHHCCCCCCCCEECCCEEEEECCHHHHHCCCHHEEHHHHHHHHHHCC
LWIVEAEDIDTGKKYTWQARGLVNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVH
EEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCEEEEECCEEEEECCC
TQKQAYILQNEDKRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLKVYNTHF
CCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
KKQLNRDDIVWTYSGVRPLCDDESDSPQAITRDYTLDIHDEDGKAPLLSVFGGKLTTYRK
HHHCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEEEEEECCCCCCCCHHHHCCCHHHHHH
LAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAARLRRRYPFLTESLARHYART
HHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHH
YGSNSELLLGNAGAISDLGENFGHEFYEAELKYLVDHEWVRRADDALWRRTKQGMWLNAD
CCCCCCEEEECCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCC
QQSRVSQWLMEYTQQRLSLAS
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1987111; 9278503; 3045087; 3045764 [H]