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The map label for this gene is rpe

Identifier: 218691662

GI number: 218691662

Start: 3946466

End: 3947143

Strand: Reverse

Name: rpe

Synonym: ECED1_4044

Alternate gene names: 218691662

Gene position: 3947143-3946466 (Counterclockwise)

Preceding gene: 218691663

Following gene: 218691661

Centisome position: 75.77

GC content: 50.15

Gene sequence:

>678_bases
ATGAAACAGTATTTGATTGCCCCCTCAATTCTGTCGGCTGATTTTGCCCGCCTGGGTGAAGATACCGCAAAAGCCCTGGC
AGCTGGCGCTGATGTCGTGCATTTTGACGTCATGGATAACCACTATGTTCCCAATCTGACGATTGGGCCAATGGTGCTGA
AATCCTTGCGTAACTACGGCATTACCGCCCCTATCGACGTACATCTGATGGTGAAACCCGTCGATCGCATTGTGCCTGAT
TTCGCTGCCGCTGGTGCCAGCATCATTACCTTTCATCCAGAAGCCTCCGAGCATGTTGACCGCACGCTGCAACTGATTAA
AGAAAATGGCTGTAAAGCGGGTTTGGTATTTAACCCGGCGACACCTCTGAGTTATCTGGATTACGTGATGGATAAGCTGG
ATGTGATCCTGCTGATGTCCGTCAATCCTGGTTTCGGCGGTCAGTCTTTCATTCCTCAAACACTGGATAAACTGCGCGAA
GTACGTCGTCGTATCGACGAGTCTGGCTTTGACATTCGACTGGAAGTGGACGGTGGCGTGAAGGTGAACAACATTGGCGA
AATCGCTGCGGCGGGCGCGGATATGTTTGTTGCTGGTTCGGCAATCTTCGACCAGCCAGACTACAAAAAAGTCATTGATG
AAATGCGCAGTGAACTGGCAAAGGTAAGTCATGAATAA

Upstream 100 bases:

>100_bases
GCAGCAACGGCGGCACACGTAAAAAGGTGGACGAACTGCTGGCTTTGTACAAACCAGGAGTCGTTTCACCCGCGAAAAAA
TAATTCTCAAGGAGAAGCGG

Downstream 100 bases:

>100_bases
GTTTGAAGATATTCGCGGCGTCGCTTTTGATCTCGACGGTACGCTGGTTGACAGTGCCCCCGGTCTTGCTGCTGCGGTAG
ATATGGCGCTGTATGCGCTG

Product: ribulose-phosphate 3-epimerase

Products: NA

Alternate protein names: Pentose-5-phosphate 3-epimerase; PPE; R5P3E

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLRNYGITAPIDVHLMVKPVDRIVPD
FAAAGASIITFHPEASEHVDRTLQLIKENGCKAGLVFNPATPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLRE
VRRRIDESGFDIRLEVDGGVKVNNIGEIAAAGADMFVAGSAIFDQPDYKKVIDEMRSELAKVSHE

Sequences:

>Translated_225_residues
MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLRNYGITAPIDVHLMVKPVDRIVPD
FAAAGASIITFHPEASEHVDRTLQLIKENGCKAGLVFNPATPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLRE
VRRRIDESGFDIRLEVDGGVKVNNIGEIAAAGADMFVAGSAIFDQPDYKKVIDEMRSELAKVSHE
>Mature_225_residues
MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLRNYGITAPIDVHLMVKPVDRIVPD
FAAAGASIITFHPEASEHVDRTLQLIKENGCKAGLVFNPATPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLRE
VRRRIDESGFDIRLEVDGGVKVNNIGEIAAAGADMFVAGSAIFDQPDYKKVIDEMRSELAKVSHE

Specific function: Unknown

COG id: COG0036

COG function: function code G; Pentose-5-phosphate-3-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribulose-phosphate 3-epimerase family

Homologues:

Organism=Homo sapiens, GI40385883, Length=221, Percent_Identity=39.8190045248869, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI219879828, Length=221, Percent_Identity=38.4615384615385, Blast_Score=152, Evalue=2e-37,
Organism=Homo sapiens, GI24307923, Length=177, Percent_Identity=32.7683615819209, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1789788, Length=225, Percent_Identity=100, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1790523, Length=197, Percent_Identity=37.5634517766497, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1790754, Length=211, Percent_Identity=28.436018957346, Blast_Score=93, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17552948, Length=217, Percent_Identity=40.5529953917051, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322341, Length=233, Percent_Identity=38.6266094420601, Blast_Score=158, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24586301, Length=214, Percent_Identity=41.1214953271028, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPE_ECO57 (P0AG09)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B86003
- PIR:   D91157
- RefSeq:   NP_289925.1
- RefSeq:   NP_312255.1
- ProteinModelPortal:   P0AG09
- SMR:   P0AG09
- MINT:   MINT-1228302
- EnsemblBacteria:   EBESCT00000026074
- EnsemblBacteria:   EBESCT00000059806
- GeneID:   915917
- GeneID:   961547
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4739
- KEGG:   ecs:ECs4228
- GeneTree:   EBGT00050000009988
- HOGENOM:   HBG571751
- OMA:   HIDRTLQ
- ProtClustDB:   PRK05581
- BioCyc:   ECOL83334:ECS4228-MONOMER
- InterPro:   IPR013785
- InterPro:   IPR000056
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR11749
- PIRSF:   PIRSF001461
- TIGRFAMs:   TIGR01163

Pfam domain/function: PF00834 Ribul_P_3_epim; SSF51366 RibP_bind_barrel

EC number: =5.1.3.1

Molecular weight: Translated: 24555; Mature: 24555

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01085 RIBUL_P_3_EPIMER_1; PS01086 RIBUL_P_3_EPIMER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLRNYG
CCCEECCHHHHHHHHHHHCHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
ITAPIDVHLMVKPVDRIVPDFAAAGASIITFHPEASEHVDRTLQLIKENGCKAGLVFNPA
CCCCEEEEEEECCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCC
TPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLREVRRRIDESGFDIRLEVDGGV
CHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCE
KVNNIGEIAAAGADMFVAGSAIFDQPDYKKVIDEMRSELAKVSHE
EECCCCHHHHCCCCCEEECCHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQYLIAPSILSADFARLGEDTAKALAAGADVVHFDVMDNHYVPNLTIGPMVLKSLRNYG
CCCEECCHHHHHHHHHHHCHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
ITAPIDVHLMVKPVDRIVPDFAAAGASIITFHPEASEHVDRTLQLIKENGCKAGLVFNPA
CCCCEEEEEEECCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEECCC
TPLSYLDYVMDKLDVILLMSVNPGFGGQSFIPQTLDKLREVRRRIDESGFDIRLEVDGGV
CHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCE
KVNNIGEIAAAGADMFVAGSAIFDQPDYKKVIDEMRSELAKVSHE
EECCCCHHHHCCCCCEEECCHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796