Click here to switch to the map view.

The map label for this gene is yphC

Identifier: 218690660

GI number: 218690660

Start: 2931841

End: 2932902

Strand: Reverse

Name: yphC

Synonym: ECED1_2972

Alternate gene names: 218690660

Gene position: 2932902-2931841 (Counterclockwise)

Preceding gene: 218690661

Following gene: 218690659

Centisome position: 56.3

GC content: 54.8

Gene sequence:

>1062_bases
ATGAAAACGATGCTGGCAGCTTATTTACCAGGAAATTCGACCGTCGATCTGCGGGAAGTTGCGGTGCCGACGCCGGGGAT
TAACCAGGTACTGATCAAAATGAAATCCTCTGGGATTTGCGGAAGCGATGTCCACTATATCTACCACCAGCACCGCGCTA
CGGCGGCGGCACCCGATAAACCGTTATACCAGGGATTTATCAACGGTCATGAACCGTGCGGGCAGATTGTGGCGATGGGG
CAAGGCTGTCGCCATTTTAAAGAGGGCGACCGCGTGCTGGTGTATCACATTTCCGGTTGTGGCTTTTGCCCGAACTGCCG
TCGCGGTTTTCCTATCTCCTGCACCGGTGAAGGAAAAGCCGCTTACGGCTGGCAGCGTGACGGCGGCCATGCTGAATACC
TGCTGGCGGAAGAAAAAGATCTGATCCTCCTGCCGGATGCACTGAGTTACGAAGATGGTGCGTTTATCAGTTGCGGCGTT
GGTACAGCGTATGAAGGGATTTTGCGCGGCGAAGTTTCCGGCAGTGATAATGTACTGGTGGTCGGTCTGGGGCCGGTCGG
CATGATGGCGATGATGCTGGCGAAAGGTCGCGGTGCAAAAAGGATCATCGGCGTTGATATGTTGCCGGAACGTCTGGCGA
TGGCGAAACAGTTAGGAGTGATGGATCACGGCTATTTAGCGACCACCGAAGGTCTGCCGCAGATAATCGCCGAACTCACT
CACGGCGGCGCGGATGTTGCGCTTGATTGTTCCGGTAATGCCGCAGGTCGCTTACTGGCACTGCAATCCACCGCTGACTG
GGGACGCGTGGTTTACATTGGTGAAACCGGAAAAGTCGAGTTCGAGGTTAGCGCTGACCTGATGCACCATCAACGGCGGA
TTATCGGCTCCTGGGTGACCAGTCTGTTCCATATGGAAAAATGCGCCCACGATTTAACGGACTGGAAACTGTGGCCGCGT
AATGCCATTACCCACCGCTTCTCGCTGGAACAGGCGGGAGATGCTTATGCACTGATGGCAAGCGGCAAATGCGGGAAAGT
TGTGATTAATTTCCCGGATTAA

Upstream 100 bases:

>100_bases
TGCTGACCCAGCGTAGCAGTAAAGCGAAACGCTAAACCTTAACGCCCCTGGCGCAGGTGCGGCAGGGATGAAAATTAATC
GTATTGTTAATGAGGGATTT

Downstream 100 bases:

>100_bases
GGAGTCTGCGGATGACCATCTATACCTTATCTCACGGGCCGCTAAAGCTGGACGTTTCTGATCAGGGCGGCGTAATCGAA
GGCTTCTGGCGCGATACGAC

Product: putative oxidoreductase, Zn-dependent and NAD(P)-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFINGHEPCGQIVAMG
QGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGEGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGV
GTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATTEGLPQIIAELT
HGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCAHDLTDWKLWPR
NAITHRFSLEQAGDAYALMASGKCGKVVINFPD

Sequences:

>Translated_353_residues
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFINGHEPCGQIVAMG
QGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGEGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGV
GTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATTEGLPQIIAELT
HGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCAHDLTDWKLWPR
NAITHRFSLEQAGDAYALMASGKCGKVVINFPD
>Mature_353_residues
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDKPLYQGFINGHEPCGQIVAMG
QGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGEGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGV
GTAYEGILRGEVSGSDNVLVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATTEGLPQIIAELT
HGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVTSLFHMEKCAHDLTDWKLWPR
NAITHRFSLEQAGDAYALMASGKCGKVVINFPD

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI71565152, Length=365, Percent_Identity=26.5753424657534, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI156523966, Length=360, Percent_Identity=26.9444444444444, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4501939, Length=354, Percent_Identity=27.1186440677966, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI156627571, Length=374, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=25.2747252747253, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI71743840, Length=363, Percent_Identity=23.6914600550964, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073058, Length=363, Percent_Identity=23.6914600550964, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=24.9322493224932, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI34577061, Length=365, Percent_Identity=25.2054794520548, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI71565154, Length=364, Percent_Identity=23.9010989010989, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI194239674, Length=365, Percent_Identity=26.5753424657534, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI13236495, Length=365, Percent_Identity=26.5753424657534, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI87082125, Length=353, Percent_Identity=100, Blast_Score=730, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=31.6860465116279, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787863, Length=366, Percent_Identity=28.9617486338798, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788407, Length=337, Percent_Identity=28.486646884273, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788073, Length=268, Percent_Identity=31.3432835820896, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI226510992, Length=324, Percent_Identity=25.9259259259259, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788075, Length=364, Percent_Identity=27.1978021978022, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786825, Length=261, Percent_Identity=27.9693486590038, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786552, Length=386, Percent_Identity=25.9067357512953, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081918, Length=350, Percent_Identity=26.5714285714286, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790718, Length=256, Percent_Identity=26.953125, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=274, Percent_Identity=32.8467153284672, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17562878, Length=251, Percent_Identity=29.4820717131474, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25146526, Length=369, Percent_Identity=23.5772357723577, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=371, Percent_Identity=23.4501347708895, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=24.633431085044, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=349, Percent_Identity=26.647564469914, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=307, Percent_Identity=24.7557003257329, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=24.9275362318841, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=342, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6322619, Length=342, Percent_Identity=28.0701754385965, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=348, Percent_Identity=26.4367816091954, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=383, Percent_Identity=22.976501305483, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=359, Percent_Identity=25.0696378830084, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=265, Percent_Identity=29.4339622641509, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=259, Percent_Identity=25.0965250965251, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=297, Percent_Identity=24.2424242424242, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=281, Percent_Identity=25.9786476868327, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=201, Percent_Identity=25.3731343283582, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137530, Length=266, Percent_Identity=30.8270676691729, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17737895, Length=365, Percent_Identity=25.2054794520548, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17737897, Length=267, Percent_Identity=29.5880149812734, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221457811, Length=336, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550770, Length=336, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551930, Length=336, Percent_Identity=23.2142857142857, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YPHC_ECOLI (P77360)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   H65031
- RefSeq:   AP_003131.1
- RefSeq:   NP_417040.2
- ProteinModelPortal:   P77360
- SMR:   P77360
- STRING:   P77360
- EnsemblBacteria:   EBESCT00000002727
- EnsemblBacteria:   EBESCT00000015226
- GeneID:   947019
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5842
- KEGG:   eco:b2545
- EchoBASE:   EB3237
- EcoGene:   EG13464
- eggNOG:   COG1063
- GeneTree:   EBGT00050000008796
- HOGENOM:   HBG753318
- OMA:   AITHRFT
- ProtClustDB:   CLSK880926
- BioCyc:   EcoCyc:YPHC-MONOMER
- Genevestigator:   P77360
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: NA

Molecular weight: Translated: 38051; Mature: 38051

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDK
CCCEEEEECCCCCCEEHHEEECCCCCCCCEEEEEECCCCCCCCHHHEEEHHCCCCCCCCC
PLYQGFINGHEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGEGKA
HHHHHHCCCCCCHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCE
AYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGVGTAYEGILRGEVSGSDNVLV
ECCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCEEEECCCCHHHHEEEEECCCCCCEEE
VGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATTEGLPQIIAELT
EEECHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
HGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVT
CCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHH
SLFHMEKCAHDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVINFPD
HHHHHHHHHHHHHCCEECCCCHHEEEEEHHHCCCEEEEEECCCCCEEEEECCC
>Mature Secondary Structure
MKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYHQHRATAAAPDK
CCCEEEEECCCCCCEEHHEEECCCCCCCCEEEEEECCCCCCCCHHHEEEHHCCCCCCCCC
PLYQGFINGHEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRGFPISCTGEGKA
HHHHHHCCCCCCHHHHHHHCCCHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCE
AYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGVGTAYEGILRGEVSGSDNVLV
ECCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCEEEECCCCHHHHEEEEECCCCCCEEE
VGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATTEGLPQIIAELT
EEECHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
HGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMHHQRRIIGSWVT
CCCCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHH
SLFHMEKCAHDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVINFPD
HHHHHHHHHHHHHCCEECCCCHHEEEEEHHHCCCEEEEEECCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503