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The map label for this gene is murP [H]

Identifier: 218690565

GI number: 218690565

Start: 2819100

End: 2820524

Strand: Direct

Name: murP [H]

Synonym: ECED1_2871

Alternate gene names: 218690565

Gene position: 2819100-2820524 (Clockwise)

Preceding gene: 218690564

Following gene: 218690570

Centisome position: 54.11

GC content: 56.56

Gene sequence:

>1425_bases
ATGGCTAAAGAGATCAGCAGTGAACTTCTGAACACCATTCTTACCCGGGTCGGCGGACCGGGAAATATCGCCAGTTGTGG
TAACTGTATGACGCGCCTGCGTCTGGGTGTACATGACAGTTCATTGGTTGATCCCGATATCAAAACGCTGGAAGGCGTGA
AGGGCGTCATTTTGACCAGCGATCAGGTGCAGGTGGTTTTTGGGCCAGGCAAAGCGCATCGTGCCGCAAAAGCCATGAGC
GAGCTGCTGGGCGAGGCACCGGTACAGGATGCCGCAGAAATCGCCGCCCAGAATAAACGCCAGTTAAAAGCCAGACAAAC
TTCCGGCGTGCAACAATTTCTCGCCAAATTCGCCACCATCTTCACGCCGCTGATCCCCGGTTTTATTGCCGCCGGTCTGC
TGCTGGGGATAGCGACGTTAATTGCCATGGTGATGCACGTTCCGGCAGATGCTCAGGGCACGCTACCCGATGCGCTGAAT
TTTATGAAGGTGTTCAGCAAAGGCCTGTTCACCTTCCTGGTAATTCTGGTGGGCTATAACGCGGCCCAGGCATTTGGTGG
CACGGGCGTAAATGGCGCAATTATCGCTGCGCTCTTTTTGCTCGGTTATAACCCCGCTGCAACCACGGGTTACTACGCCG
GATTTCACGATTTCTTTGGTCTGCCTATCGATCCGCGCGGCAATATTATCGGCGTGTTGATTGCCGCATGGGCCTGCGCC
CGCATCGAATGCATGGTGCGCCGCTTTATGCCGGACGACCTCGACATGCTGTTGACCTCATTAATCACCCTGCTGATCAC
CGCTACGCTTGCGTACCTGATCATTATGCCGCTGGGCGGCTGGCTGTTTGAAGGCATGTCGTGGCTGTTTATGCACCTGA
ACAGTAATCCGCTCGGTTGTGCGGTTTTAGCCGGGCTGTTCCTGATCGCCGTGGTATTTGGCGTGCATCAGGGCTTTATT
CCTGTTTATCTGGCGTTAATGGACAGCCAGGGATTCAACAGCTTATTTCCCATCCTTTCAATGGCAGGCGCAGGCCAGGT
GGGCGCGGCGCTGGCGCTCTACTGGCGGGCGCAACCGCACAGTGCATTACGCAGTCAGGTCCGCGGGGCGATTATTCCCG
GTCTGCTTGGCGTTGGCGAACCGCTGATTTACGGTGTCACCCTGCCCCGCATGAAACCGTTTGTTACCGCCTGTTTAGGC
GGCGCGGCGGGCGGTTTGTTTATCGGGCTGATAGCCTGGTGGGGTCTGCCGATGGGCTTAAATAGCGCCTTCGGGCCGTC
TGGTCTGGTGGCGCTGCCGCTGATGACTTCCGCGCAAGGCATCCTTCCGGCAATGGCGGTTTATGCAGGCGGGATTCTGG
TGGCATGGGTTTGCGGGTTTATTTTCACCACGCTCTTTGGCTGCCGTAACGTCAATCTGGACTGA

Upstream 100 bases:

>100_bases
TATTGTGATGGTACTGAAAAATCTCGATGCCGATGAAGCTAAAAAATGCCTGGATCAACACGGCGGTTTTATTCGCAAGG
CTCTGGAAAAGGAATAACCC

Downstream 100 bases:

>100_bases
TAATATGAAACGGACAATGCTCTATCTTTCTCTGCTGGCTGTCAGCTGTAGCGTCAGCGCCACAAAATACCCTGTTCTGA
CAGAAAGTAGTTGATCAAGT

Product: PTS system N-acetylmuramic acid transporter subunits EIIBC

Products: NA

Alternate protein names: EIIBC-MurNAc; N-acetylmuramic acid-specific phosphotransferase enzyme IIB component; PTS system N-acetylmuramic acid-specific EIIB component; N-acetylmuramic acid permease IIC component; PTS system N-acetylmuramic acid-specific EIIC component [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPDIKTLEGVKGVILTSDQVQVVFGPGKAHRAAKAMS
ELLGEAPVQDAAEIAAQNKRQLKARQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIAMVMHVPADAQGTLPDALN
FMKVFSKGLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACA
RIECMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPLGCAVLAGLFLIAVVFGVHQGFI
PVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFVTACLG
GAAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMAVYAGGILVAWVCGFIFTTLFGCRNVNLD

Sequences:

>Translated_474_residues
MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPDIKTLEGVKGVILTSDQVQVVFGPGKAHRAAKAMS
ELLGEAPVQDAAEIAAQNKRQLKARQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIAMVMHVPADAQGTLPDALN
FMKVFSKGLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACA
RIECMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPLGCAVLAGLFLIAVVFGVHQGFI
PVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFVTACLG
GAAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMAVYAGGILVAWVCGFIFTTLFGCRNVNLD
>Mature_473_residues
AKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPDIKTLEGVKGVILTSDQVQVVFGPGKAHRAAKAMSE
LLGEAPVQDAAEIAAQNKRQLKARQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIAMVMHVPADAQGTLPDALNF
MKVFSKGLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACAR
IECMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPLGCAVLAGLFLIAVVFGVHQGFIP
VYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFVTACLGG
AAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMAVYAGGILVAWVCGFIFTTLFGCRNVNLD

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788769, Length=474, Percent_Identity=98.9451476793249, Blast_Score=934, Evalue=0.0,
Organism=Escherichia coli, GI1790159, Length=435, Percent_Identity=29.6551724137931, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI2367362, Length=428, Percent_Identity=26.8691588785047, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI48994906, Length=487, Percent_Identity=26.0780287474333, Blast_Score=113, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018113
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013 [H]

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 49874; Mature: 49743

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00024 HEMOPEXIN ; PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPDIKTLEGVKGVILTS
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEC
DQVQVVFGPGKAHRAAKAMSELLGEAPVQDAAEIAAQNKRQLKARQTSGVQQFLAKFATI
CCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTPLIPGFIAAGLLLGIATLIAMVMHVPADAQGTLPDALNFMKVFSKGLFTFLVILVGYN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACA
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
RIECMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPLGC
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
AVLAGLFLIAVVFGVHQGFIPVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPH
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCH
SALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFVTACLGGAAGGLFIGLIAWWGLPMGL
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NSAFGPSGLVALPLMTSAQGILPAMAVYAGGILVAWVCGFIFTTLFGCRNVNLD
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPDIKTLEGVKGVILTS
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEC
DQVQVVFGPGKAHRAAKAMSELLGEAPVQDAAEIAAQNKRQLKARQTSGVQQFLAKFATI
CCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTPLIPGFIAAGLLLGIATLIAMVMHVPADAQGTLPDALNFMKVFSKGLFTFLVILVGYN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACA
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
RIECMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPLGC
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
AVLAGLFLIAVVFGVHQGFIPVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPH
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCH
SALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFVTACLGGAAGGLFIGLIAWWGLPMGL
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NSAFGPSGLVALPLMTSAQGILPAMAVYAGGILVAWVCGFIFTTLFGCRNVNLD
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]