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The map label for this gene is glpA [H]

Identifier: 218690403

GI number: 218690403

Start: 2642732

End: 2644360

Strand: Direct

Name: glpA [H]

Synonym: ECED1_2706

Alternate gene names: 218690403

Gene position: 2642732-2644360 (Clockwise)

Preceding gene: 218690399

Following gene: 218690404

Centisome position: 50.73

GC content: 57.03

Gene sequence:

>1629_bases
ATGAAAACTCGCGACTCGCAATCAAGTGACGTGATTATCATTGGCGGTGGCGCAACGGGAGCCGGGATTGCCCGCGACTG
TGCCCTGCGCGGGCTGCGCGTGATTTTGGTTGAGCGCCACGACATCGCAACCGGTGCCACCGGGCGTAACCACGGCCTGC
TGCACAGCGGTGCGCGCTATGCGGTAACCGATGCGGAATCGGCCCGCGAATGTATTAGTGAAAACCAGATCCTGAAACGC
ATTGCACGTCACTGCGTAGAACCAACCAACGGCCTGTTTATCACCCTGCCGGAAGATGACCTCTCCTTCCAGGCCACTTT
TATCCGCGCCTGCGAAGAAGCAGGGATCAGCGCAGAAGCCATTGATCCGCAGCAAGCGCGCATTATCGAACCTGCCGTTA
ACCCGGCACTGATTGGCGCGGTGAAAGTTCCGGATGGCACCGTTGATCCATTTCGTCTGACTACAGCAAATATGCTGGAT
GCCAAAGAACACGGTGCGGTTATCCTTACTGCTCATGAAGTCACGGGACTCATTCGTGAAGGCGCGACGGTGTGCGGTGT
TCGTGTACGTAACCATCTCACCGGCGAAATTCAGACACTTCATGCGCCTGTCGTAGTTAATGCCGCCGGGATCTGGGGGC
AACACATTGCCGAATATGCCGATCTGCGCATTCGCATGTTCCCGGCGAAAGGATCGCTGCTGATCATGGATCACCGCATT
AATCAGCATGTGATCAACCGCTGCCGCAAACCTTCCGACGCCGATATTCTGGTGCCTGGCGATACCATTTCGCTGATTGG
CACCACCTCTTTACGTATTGATTACAACGAGATTGACGATAATCGAGTGACGGCAGAAGAAGTTGATATTCTGCTGCGCG
AAGGGGAAAAACTGGCCCCCGTGATGGCGAAAACGCGCATTTTGCGGGCCTACTCTGGCGTACGCCCGCTGGTTGCCAGC
GATGACGATCCGAGCGGACGTAACGTCAGCCGTGGCATCGTGCTGCTCGACCATGCTGAACGCGATGGTCTGGACGGGTT
TATCACCATCACCGGTGGCAAACTGATGACCTATCGGCTGATGGCGGAATGGGCTACCGACGCCGTATGCCGCAAACTGG
GAAACACGCGCCCCTGTACGACCGCCGATCTGGCACTTCCTGGTTCACAGGAACCCGCTGAAGTTACCTTGCGTAAAGTC
ATCTCCCTGCCTGCCCCGCTGCGCGGTTCTGCGGTTTATCGTCATGGCGATCGCACGCCTGCCTGGCTGAGCGAAGGCCG
TCTGCACCGTAGCCTGGTATGTGAGTGCGAAGCGGTAACTGCGGGTGAAGTGCAGTACGCGGTAGAAAATTTAAACGTTA
ATAGCCTGCTGGATTTACGCCGTCGTACCCGTGTGGGGATGGGCACCTGCCAGGGCGAGCTCTGCGCCTGCCGCGCTGCC
GGACTGCTGCAACGTTTTAACGTCACGACGTCCGCGCAATCTATCGAGCAACTTTCCACCTTCCTAAACGAACGCTGGAA
AGGCGTGCAACCCATCGCCTGGGGAGATGCACTGCGCGAAAGCGAATTTACCCGCTGGGTTTATCAGGGATTGTGTGGTC
TGGAGAAGGAGCAGAAAGATGCGCTTTGA

Upstream 100 bases:

>100_bases
CACGTTTCACTTTCGAATTATGAGCGAATATGCGCGAAATCAAACAATTCATGTTTTTACTATGGCTAAATGGTAAAAAA
CGAACTTCAGAGGGATAACA

Downstream 100 bases:

>100_bases
TACTGTCATTATGGGCGGCGGCCTCGCCGGATTACTCTGTGGCCTGCAACTGCAAAAACACGGCCTGCGCTGTGCCATTG
TCACTCGTGGTCAAAGCGCG

Product: sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MKTRDSQSSDVIIIGGGATGAGIARDCALRGLRVILVERHDIATGATGRNHGLLHSGARYAVTDAESARECISENQILKR
IARHCVEPTNGLFITLPEDDLSFQATFIRACEEAGISAEAIDPQQARIIEPAVNPALIGAVKVPDGTVDPFRLTTANMLD
AKEHGAVILTAHEVTGLIREGATVCGVRVRNHLTGEIQTLHAPVVVNAAGIWGQHIAEYADLRIRMFPAKGSLLIMDHRI
NQHVINRCRKPSDADILVPGDTISLIGTTSLRIDYNEIDDNRVTAEEVDILLREGEKLAPVMAKTRILRAYSGVRPLVAS
DDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDAVCRKLGNTRPCTTADLALPGSQEPAEVTLRKV
ISLPAPLRGSAVYRHGDRTPAWLSEGRLHRSLVCECEAVTAGEVQYAVENLNVNSLLDLRRRTRVGMGTCQGELCACRAA
GLLQRFNVTTSAQSIEQLSTFLNERWKGVQPIAWGDALRESEFTRWVYQGLCGLEKEQKDAL

Sequences:

>Translated_542_residues
MKTRDSQSSDVIIIGGGATGAGIARDCALRGLRVILVERHDIATGATGRNHGLLHSGARYAVTDAESARECISENQILKR
IARHCVEPTNGLFITLPEDDLSFQATFIRACEEAGISAEAIDPQQARIIEPAVNPALIGAVKVPDGTVDPFRLTTANMLD
AKEHGAVILTAHEVTGLIREGATVCGVRVRNHLTGEIQTLHAPVVVNAAGIWGQHIAEYADLRIRMFPAKGSLLIMDHRI
NQHVINRCRKPSDADILVPGDTISLIGTTSLRIDYNEIDDNRVTAEEVDILLREGEKLAPVMAKTRILRAYSGVRPLVAS
DDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDAVCRKLGNTRPCTTADLALPGSQEPAEVTLRKV
ISLPAPLRGSAVYRHGDRTPAWLSEGRLHRSLVCECEAVTAGEVQYAVENLNVNSLLDLRRRTRVGMGTCQGELCACRAA
GLLQRFNVTTSAQSIEQLSTFLNERWKGVQPIAWGDALRESEFTRWVYQGLCGLEKEQKDAL
>Mature_542_residues
MKTRDSQSSDVIIIGGGATGAGIARDCALRGLRVILVERHDIATGATGRNHGLLHSGARYAVTDAESARECISENQILKR
IARHCVEPTNGLFITLPEDDLSFQATFIRACEEAGISAEAIDPQQARIIEPAVNPALIGAVKVPDGTVDPFRLTTANMLD
AKEHGAVILTAHEVTGLIREGATVCGVRVRNHLTGEIQTLHAPVVVNAAGIWGQHIAEYADLRIRMFPAKGSLLIMDHRI
NQHVINRCRKPSDADILVPGDTISLIGTTSLRIDYNEIDDNRVTAEEVDILLREGEKLAPVMAKTRILRAYSGVRPLVAS
DDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDAVCRKLGNTRPCTTADLALPGSQEPAEVTLRKV
ISLPAPLRGSAVYRHGDRTPAWLSEGRLHRSLVCECEAVTAGEVQYAVENLNVNSLLDLRRRTRVGMGTCQGELCACRAA
GLLQRFNVTTSAQSIEQLSTFLNERWKGVQPIAWGDALRESEFTRWVYQGLCGLEKEQKDAL

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=541, Percent_Identity=25.6931608133087, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI285002231, Length=541, Percent_Identity=25.6931608133087, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI197927446, Length=288, Percent_Identity=23.9583333333333, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI21361378, Length=288, Percent_Identity=23.9583333333333, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788574, Length=542, Percent_Identity=99.4464944649446, Blast_Score=1099, Evalue=0.0,
Organism=Escherichia coli, GI2367226, Length=379, Percent_Identity=25.3298153034301, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115534726, Length=417, Percent_Identity=26.6187050359712, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17509253, Length=414, Percent_Identity=29.4685990338164, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161077125, Length=414, Percent_Identity=29.2270531400966, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24653942, Length=414, Percent_Identity=29.2270531400966, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24653944, Length=414, Percent_Identity=29.2270531400966, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20130025, Length=414, Percent_Identity=29.2270531400966, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24586295, Length=394, Percent_Identity=25.1269035532995, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 59031; Mature: 59031

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00977 FAD_G3PDH_1 ; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRDSQSSDVIIIGGGATGAGIARDCALRGLRVILVERHDIATGATGRNHGLLHSGARY
CCCCCCCCCCEEEEECCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCEECCCEE
AVTDAESARECISENQILKRIARHCVEPTNGLFITLPEDDLSFQATFIRACEEAGISAEA
EEECHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCC
IDPQQARIIEPAVNPALIGAVKVPDGTVDPFRLTTANMLDAKEHGAVILTAHEVTGLIRE
CCCHHHEEECCCCCCEEEEEEECCCCCCCCEEEEHHHHHCCCCCCEEEEEHHHHHHHHHC
GATVCGVRVRNHLTGEIQTLHAPVVVNAAGIWGQHIAEYADLRIRMFPAKGSLLIMDHRI
CCCEEEEEHHCCCCCCEEEEECCEEEEECCHHHHHHHHHHCEEEEEEECCCCEEEEECCC
NQHVINRCRKPSDADILVPGDTISLIGTTSLRIDYNEIDDNRVTAEEVDILLREGEKLAP
CHHHHHHCCCCCCCEEEECCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHH
VMAKTRILRAYSGVRPLVASDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRL
HHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEHHH
MAEWATDAVCRKLGNTRPCTTADLALPGSQEPAEVTLRKVISLPAPLRGSAVYRHGDRTP
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCC
AWLSEGRLHRSLVCECEAVTAGEVQYAVENLNVNSLLDLRRRTRVGMGTCQGELCACRAA
HHHHCCCCCHHHEEEECCCCCCHHEEHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
GLLQRFNVTTSAQSIEQLSTFLNERWKGVQPIAWGDALRESEFTRWVYQGLCGLEKEQKD
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHC
AL
CC
>Mature Secondary Structure
MKTRDSQSSDVIIIGGGATGAGIARDCALRGLRVILVERHDIATGATGRNHGLLHSGARY
CCCCCCCCCCEEEEECCCCCCCHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCEECCCEE
AVTDAESARECISENQILKRIARHCVEPTNGLFITLPEDDLSFQATFIRACEEAGISAEA
EEECHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCC
IDPQQARIIEPAVNPALIGAVKVPDGTVDPFRLTTANMLDAKEHGAVILTAHEVTGLIRE
CCCHHHEEECCCCCCEEEEEEECCCCCCCCEEEEHHHHHCCCCCCEEEEEHHHHHHHHHC
GATVCGVRVRNHLTGEIQTLHAPVVVNAAGIWGQHIAEYADLRIRMFPAKGSLLIMDHRI
CCCEEEEEHHCCCCCCEEEEECCEEEEECCHHHHHHHHHHCEEEEEEECCCCEEEEECCC
NQHVINRCRKPSDADILVPGDTISLIGTTSLRIDYNEIDDNRVTAEEVDILLREGEKLAP
CHHHHHHCCCCCCCEEEECCCEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHCCCHHHH
VMAKTRILRAYSGVRPLVASDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRL
HHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEHHH
MAEWATDAVCRKLGNTRPCTTADLALPGSQEPAEVTLRKVISLPAPLRGSAVYRHGDRTP
HHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCCC
AWLSEGRLHRSLVCECEAVTAGEVQYAVENLNVNSLLDLRRRTRVGMGTCQGELCACRAA
HHHHCCCCCHHHEEEECCCCCCHHEEHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHH
GLLQRFNVTTSAQSIEQLSTFLNERWKGVQPIAWGDALRESEFTRWVYQGLCGLEKEQKD
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHC
AL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]