Click here to switch to the map view.

The map label for this gene is atoB [H]

Identifier: 218690388

GI number: 218690388

Start: 2616494

End: 2617678

Strand: Direct

Name: atoB [H]

Synonym: ECED1_2691

Alternate gene names: 218690388

Gene position: 2616494-2617678 (Clockwise)

Preceding gene: 218690387

Following gene: 218690395

Centisome position: 50.22

GC content: 53.67

Gene sequence:

>1185_bases
ATGAAAAATTGTGTCATCGTCAGTGCGGTACGTACTGCTATCGGTAGTTTTAACGGTTCACTCGCGTCCACCAGCGCCAT
CGACCTGGGGGCGACAGTAATTAAAGCCGCCATTGAACGTGCAAAAATCGATTCACTACACGTTGATGAAGTGATTATGG
GTAACGTGTTGCAAGCCGGACTGGGGCAAAATCCGGCACGTCAGGCGCTGCTAAAAAGCGGACTGGCTGAAACGGTGTGC
GGATTCACGGTCAACAAAGTGTGCGGTTCAGGTCTGAAAAGCGTGGCGCTTGCTGCACAGGCGATTCAGGCAGGTCAGGC
ACAGAGCATTGTGGCGGGGGGTATGGAAAATATGAGTTTAGCGCCCTACTTACTCGATGCAAAAGCACGCTCTGGTTATC
GTCTTGGAGACGGACAGGTTTATGACGTAATCCTGCGCGATGGCCTGATGTGCGCCACCCATGGTTATCATATGGGGATT
ACCGCCGAAAACGTGGCTAAAGAGTACGGAATTACCCGTGAAATGCAGGATGAACTGGCGCTACATTCACAGCGTAAAGC
TGCAGCCGCAATTGAGTCCGGTGCTTTTACAGCCGAAATCGTCCCGGTAAATATTGTCACCCGGAAGAAAACCCTCGTCT
TCAGTCAAGACGAATTCCCGAAAGTGGATTCTACGGCTGAAGCGTTAGGCGCATTGCGCCCGGCCTTCGATAAAGCAGGA
ACAGTCACCGCCGGGAACGCGTCTGGCATTAACGACGGTGCTGCCGCTCTGGTGATTATGGATGAATCTGCGGCGCTGGC
AGCAGGCCTTACCCCCCTGGCTCGCATTAAAAGTTATGCCAGCGGTGGCGTGCCCCCCGCATTGATGGGTATGGGGCCAG
TACCTGCCACGCAAAAAGCGTTACAACTGGCGGGGCTGCAACTGGCGGATATTGATCTCATTGAGGCTAATGAAGCATTT
GCTGCACAGTTCCTTGCCGTTGGGAAAACCCTGGGCTTTGATCCTGAGAAAGTGAATGTCAACGGCGGGGCCATCGCGCT
GGGGCATCCTATCGGTGCCAGTGGTGCTCGTATTCTGGTCACACTATTACATGCAATGCAGGCACGCGATAAAACGCTGG
GGCTGGCAACACTGTGCATTGGTGGCGGCCAGGGAATTGCGATGGTGATTGAGCGGTTGAATTAA

Upstream 100 bases:

>100_bases
CATGGGCTATTGCATCACTGCCCTGCTCTTCTCCGGCGTCATTTTCGTCATTGGTTTAACGCTGTTCTGACGGCAACCCT
ACAAACAGAAGGAATATAAA

Downstream 100 bases:

>100_bases
CCAATAAAAACGCCCGATAGCGAAAGTTATCGGGCGTTTTCTTGAACATCGACGGCGAAGGTAACCCCATTAATCACCAG
TCAAAACTTTTCACCAGCGT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDELALHSQRKAAAAIESGAFTAEIVPVNIVTRKKTLVFSQDEFPKVDSTAEALGALRPAFDKAG
TVTAGNASGINDGAAALVIMDESAALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN

Sequences:

>Translated_394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDELALHSQRKAAAAIESGAFTAEIVPVNIVTRKKTLVFSQDEFPKVDSTAEALGALRPAFDKAG
TVTAGNASGINDGAAALVIMDESAALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
>Mature_394_residues
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAGLGQNPARQALLKSGLAETVC
GFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSLAPYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGI
TAENVAKEYGITREMQDELALHSQRKAAAAIESGAFTAEIVPVNIVTRKKTLVFSQDEFPKVDSTAEALGALRPAFDKAG
TVTAGNASGINDGAAALVIMDESAALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKALQLAGLQLADIDLIEANEAF
AAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILVTLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=54.1025641025641, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=43.1818181818182, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI4557237, Length=396, Percent_Identity=44.9494949494949, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI4501853, Length=401, Percent_Identity=41.3965087281795, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=32.9411764705882, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=32.5757575757576, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=97.9695431472081, Blast_Score=746, Evalue=0.0,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=58.4183673469388, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1787663, Length=404, Percent_Identity=45.5445544554455, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=43.3915211970075, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=423, Percent_Identity=35.9338061465721, Blast_Score=201, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=45.8015267175573, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=44.2748091603053, Blast_Score=304, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=42.2784810126582, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17535917, Length=404, Percent_Identity=33.9108910891089, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=32.8638497652582, Blast_Score=185, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=44.9748743718593, Blast_Score=303, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=37.7833753148615, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=52.7918781725888, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=47.2081218274112, Blast_Score=314, Evalue=8e-86,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=43.6224489795918, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.7647058823529, Blast_Score=171, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40330; Mature: 40330

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAG
CCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
LGQNPARQALLKSGLAETVCGFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSL
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
APYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGITAENVAKEYGITREMQDELA
CCEEEECCCCCCCCCCCCCEEEEHHHCCEEEEECCEEECCCHHHHHHHHCCCHHHHHHHH
LHSQRKAAAAIESGAFTAEIVPVNIVTRKKTLVFSQDEFPKVDSTAEALGALRPAFDKAG
HHHHHHHHHHHHCCCEEEEEEEEEEEEECEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
TVTAGNASGINDGAAALVIMDESAALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKA
CEECCCCCCCCCCCEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCHHHHCCCCCCHHHHH
LQLAGLQLADIDLIEANEAFAAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILV
HHHHCCEEECEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
HHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCC
>Mature Secondary Structure
MKNCVIVSAVRTAIGSFNGSLASTSAIDLGATVIKAAIERAKIDSLHVDEVIMGNVLQAG
CCCCEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
LGQNPARQALLKSGLAETVCGFTVNKVCGSGLKSVALAAQAIQAGQAQSIVAGGMENMSL
CCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCC
APYLLDAKARSGYRLGDGQVYDVILRDGLMCATHGYHMGITAENVAKEYGITREMQDELA
CCEEEECCCCCCCCCCCCCEEEEHHHCCEEEEECCEEECCCHHHHHHHHCCCHHHHHHHH
LHSQRKAAAAIESGAFTAEIVPVNIVTRKKTLVFSQDEFPKVDSTAEALGALRPAFDKAG
HHHHHHHHHHHHCCCEEEEEEEEEEEEECEEEEECCCCCCCCCHHHHHHHHHHHHHCCCC
TVTAGNASGINDGAAALVIMDESAALAAGLTPLARIKSYASGGVPPALMGMGPVPATQKA
CEECCCCCCCCCCCEEEEEEECCCHHHHCCCHHHHHHHHHCCCCCHHHHCCCCCCHHHHH
LQLAGLQLADIDLIEANEAFAAQFLAVGKTLGFDPEKVNVNGGAIALGHPIGASGARILV
HHHHCCEEECEEEEECCHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCHHHHHH
TLLHAMQARDKTLGLATLCIGGGQGIAMVIERLN
HHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]