Click here to switch to the map view.

The map label for this gene is hemA [H]

Identifier: 218689157

GI number: 218689157

Start: 1346114

End: 1347370

Strand: Direct

Name: hemA [H]

Synonym: ECED1_1358

Alternate gene names: 218689157

Gene position: 1346114-1347370 (Clockwise)

Preceding gene: 218689152

Following gene: 218689158

Centisome position: 25.84

GC content: 53.3

Gene sequence:

>1257_bases
ATGACCCTTTTAGCACTCGGTATCAACCATAAAACGGCACCTGTATCGCTGCGAGAACGTGTATCGTTTTCGCCGGATAA
GCTCGATCAGGCGCTTGACAGCCTGCTTGCGCAGCCGATGGTGCAGGGCGGTGTGGTGCTGTCGACGTGTAACCGCACAG
AACTTTATCTCAGCGTTGAAGAACGGGATGACCTGCAAGAGGCGCTCATTCGCTGGTTGTGTGATTACCATAATCTCAAC
GAAGACGATCTGCGTAATAGCCTCTACTGGCATCAGGATAACGATGCGGTCAGTCATTTAATGCGCGTTGCCAGTGGGCT
TGATTCTCTCGTCCTTGGCGAGCCGCAGATCCTCGGTCAGGTTAAAAAAGCGTTTGCCGATTCGCAAAAAGGTCATATGA
AGGCCAGCGAACTGGAACGCATGTTTCAGAAATCTTTCTCTGTGGCGAAACGCGTTCGCACTGAAACAGATATCGGTGCC
AGTGCTGTGTCTGTCGCTTTTGCGGCTTGTACGCTGGCGCGGCAGATCTTTGAATCGCTCTCTACGGTGACGGTACTGCT
GGTTGGCGCGGGCGAAACCATCGAGCTGGTGGCACGTCATCTGCGCGAACACAAAGTACAGAAGATGATTATCGCCAATC
GCACTCGCGAACGTGCCCAAATTCTGGCAGATGAGGTTGGCGCGGAAGTGATTGCCCTGAGTGATATCGACGAACGTCTG
CGCGAAGCCGATATCATCATCAGTTCCACCGCCAGCCCGTTGCCGATTATCGGTAAAGGCATGGTGGAGCGCGCATTAAA
AAGCCGTCGCAATCAACCAATGCTGCTGGTGGATATTGCCGTTCCGCGCGATGTTGAGCCGGAAGTTGGTAAACTGGCGA
ATGCTTATCTTTATAGCGTTGACGATCTGCAAAGCATTATTTCGCACAACCTGGCGCAACGGAAAGCTGCTGCTGTGGAG
GCGGAAACTATCGTCGCCCAGGAGGCCAGTGAATTTATGGCATGGCTTCGAGCACAAAGCGCCAGCGAAACTATTCGCGA
TTATCGTAGCCAGGCAGAGCAGGTTCGTGATGAGTTAACTGCTAAAGCGTTAGCGGCCCTTGAACAGGGCGGCGATGCGC
AAACCATTATGCAGGATCTGGCATGGAAACTGACTAACCGCCTGATCCATGCACCAACAAAATCACTTCAACAGGCCGCC
CGTGACGGGGATAACGAACGCCTGAATATTCTGCGCGACAGCCTCGGGCTGGAGTAG

Upstream 100 bases:

>100_bases
CAATTACTCCAAAAGGGGGCGCTCTCTTTTATTGATCTTACGCATCCTGTATGATGCAAGCAGACTAACCCTATCAACGT
TGGTATTATTTCCCGCAGAC

Downstream 100 bases:

>100_bases
CAGTACATCATTTTCTTTTTTTACAGGGTGCATTTACGCCTATGAAGCCTTCTATCGTTGCCAAACTGGAAGCCCTGCAT
GAACGCCATGAAGAAGTTCA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEERDDLQEALIRWLCDYHNLN
EDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGA
SAVSVAFAACTLARQIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERL
READIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVE
AETIVAQEASEFMAWLRAQSASETIRDYRSQAEQVRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAA
RDGDNERLNILRDSLGLE

Sequences:

>Translated_418_residues
MTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEERDDLQEALIRWLCDYHNLN
EDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGA
SAVSVAFAACTLARQIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERL
READIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVE
AETIVAQEASEFMAWLRAQSASETIRDYRSQAEQVRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAA
RDGDNERLNILRDSLGLE
>Mature_417_residues
TLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVEERDDLQEALIRWLCDYHNLNE
DDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQVKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGAS
AVSVAFAACTLARQIFESLSTVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERLR
EADIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSVDDLQSIISHNLAQRKAAAVEA
ETIVAQEASEFMAWLRAQSASETIRDYRSQAEQVRDELTAKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAAR
DGDNERLNILRDSLGLE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=98.3253588516746, Blast_Score=835, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 46294; Mature: 46163

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVE
CEEEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEH
ERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQ
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCEECCCHHHHHHHHHHHCCHHHHCCCHHHHHH
VKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLARQIFESL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
STVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERL
HHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEHHHHHHHH
READIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSV
HHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DDLQSIISHNLAQRKAAAVEAETIVAQEASEFMAWLRAQSASETIRDYRSQAEQVRDELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDSLGLE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TLLALGINHKTAPVSLRERVSFSPDKLDQALDSLLAQPMVQGGVVLSTCNRTELYLSVE
EEEEEECCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCEEEEEEEH
ERDDLQEALIRWLCDYHNLNEDDLRNSLYWHQDNDAVSHLMRVASGLDSLVLGEPQILGQ
HHHHHHHHHHHHHHHHCCCCHHHHHCCCCEECCCHHHHHHHHHHHCCHHHHCCCHHHHHH
VKKAFADSQKGHMKASELERMFQKSFSVAKRVRTETDIGASAVSVAFAACTLARQIFESL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
STVTVLLVGAGETIELVARHLREHKVQKMIIANRTRERAQILADEVGAEVIALSDIDERL
HHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEHHHHHHHH
READIIISSTASPLPIIGKGMVERALKSRRNQPMLLVDIAVPRDVEPEVGKLANAYLYSV
HHHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
DDLQSIISHNLAQRKAAAVEAETIVAQEASEFMAWLRAQSASETIRDYRSQAEQVRDELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKALAALEQGGDAQTIMQDLAWKLTNRLIHAPTKSLQQAARDGDNERLNILRDSLGLE
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA