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The map label for this gene is umuC [H]

Identifier: 218689127

GI number: 218689127

Start: 1311024

End: 1312286

Strand: Direct

Name: umuC [H]

Synonym: ECED1_1326

Alternate gene names: 218689127

Gene position: 1311024-1312286 (Clockwise)

Preceding gene: 218689126

Following gene: 218689130

Centisome position: 25.17

GC content: 50.83

Gene sequence:

>1263_bases
ATGTTTGCCCTCTGTGATGTAAACGCGTTTTATGCCAGCTGTGAGACGGTGTTTCGCCCTGATTTATGGGGTAAACCGGT
GGTTGTGCTATCGAATAACGACGGTTGCGTTATCGCCCGAAACGCAAAGGCGCTGGGCGTTAAAATGGGCGATCCCTGGT
TCAAACAAAAAGATCTGTTTCGTCGCTGTGGCGTGGTTTGCTTTAGCAGCAATTATGAGCTTTACGCAGACATGAGTAAT
CGGGTGATGTCGACGCTGGAAGAACTATCGCCCCGCGTCGAGATTTACAGTATTGATGAGGCATTCTGCGATCTGACAGG
TGTGCATAATTGTCGCGATCTGACTGATTTTGGCAGAGAAATTTGCGCAACGGTGCTACAACGTACCCATCTTACTGTTG
GTGTGGGGATCGCCCAGACCAAAACGCTGGCTAAGCTTGCCAATCATGCGGCAAAAAAATGGCAGCGGCAGACGGGCGGG
GTGGTGGATTTATCAAATCTGGAACGCCAGCGTAAATTAATGTCTGCTCTCCCCGTGGATGAAGTCTGGGGGATTGGACG
GCGGATCAGCAAAAAACTGGACGCGATGGGGATCAAAACCGTTCTCGATTTGGCGGATTCAGATATCCGGTTTATCCGTA
AACATTTTAATGTCGTGCTCGAAAGAACGGTGCGTGAACTGCGCGGTGAACCCTGTTTGCAACTGGAAGAGTTTGCACCG
ACGAAGCAGGAAATTATCTGTTCCCGCTCGTTTGGTGAACGCATCACGGATTATCCGTCGATGCGGCAGGCCATTTGTAG
TTACGCTGCCCGGGCGGCGGAAAAACTTCGCAGCGAGCATCAATATTGTCGGTTTATCTCCACGTTTATTAAGACGTCAC
CATTTGCGTTCAATGAACCTTATTACGGCAATAGCGCATCGGTAAAACTGCTGACGCCCACTCAGGACAGCAGGGATATC
ATTAACGCCGCTACGCGATCTCTGGATGCCATCTGGCAAGCGGGCCATCGCTACCAAAAAGCGGGCGTGATGCTGGGGGA
TTTCTTCAGTCAGGGAGTCGCGCAGCTCAATTTATTCGATGACAACGCACCGCGCCCCGGGAGTGAGCAATTGATGGCGG
TAATGGATACGCTGAATGCTAAAGAGGGCAGAGGAACACTCTATTTTGCCGGGCAGGGGATCCAGCAACAATGGCAGATG
AAGCGTGCCATGCTTTCACCATGTTATACAACGCGAAGTTCTGATTTACTGCGGGTCAAATAA

Upstream 100 bases:

>100_bases
TTATTCCTATGAACAGTGCGTACTCGCCCATTACCATCAGTAGCGAAGATACGCTGGATGTCTTTGGTGTGGTGATCCAC
GTCGTTAAGGCGATGCGCTG

Downstream 100 bases:

>100_bases
ACATAGCGGCAGGAAAAAGCGCTCCCGCAGGAGCGCCGAATGGATTAGCGACCGAACAGGTCACGTTTTTTCGCTTTAAA
CGGCTGGGAAATCACCACCA

Product: DNA polymerase V subunit UmuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADMSN
RVMSTLEELSPRVEIYSIDEAFCDLTGVHNCRDLTDFGREICATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGG
VVDLSNLERQRKLMSALPVDEVWGIGRRISKKLDAMGIKTVLDLADSDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAP
TKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFAFNEPYYGNSASVKLLTPTQDSRDI
INAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQM
KRAMLSPCYTTRSSDLLRVK

Sequences:

>Translated_420_residues
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADMSN
RVMSTLEELSPRVEIYSIDEAFCDLTGVHNCRDLTDFGREICATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGG
VVDLSNLERQRKLMSALPVDEVWGIGRRISKKLDAMGIKTVLDLADSDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAP
TKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFAFNEPYYGNSASVKLLTPTQDSRDI
INAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQM
KRAMLSPCYTTRSSDLLRVK
>Mature_420_residues
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADMSN
RVMSTLEELSPRVEIYSIDEAFCDLTGVHNCRDLTDFGREICATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGG
VVDLSNLERQRKLMSALPVDEVWGIGRRISKKLDAMGIKTVLDLADSDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAP
TKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFAFNEPYYGNSASVKLLTPTQDSRDI
INAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQM
KRAMLSPCYTTRSSDLLRVK

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=422, Percent_Identity=97.867298578199, Blast_Score=857, Evalue=0.0,
Organism=Escherichia coli, GI1786425, Length=219, Percent_Identity=26.4840182648402, Blast_Score=72, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 47359; Mature: 47359

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAKALGVKMGDPWFKQKDLF
CEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCEEEEECCCCCHHHHHHH
RRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVHNCRDLTDFGRE
HHCCEEEECCCCEEEECHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCHHHHHHHHHH
ICATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALPVD
HHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCHH
EVWGIGRRISKKLDAMGIKTVLDLADSDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAP
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC
TKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFAFNEP
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFD
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHCCHHEEEEEC
DNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPCYTTRSSDLLRVK
CCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHCCCCCCEEECC
>Mature Secondary Structure
MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAKALGVKMGDPWFKQKDLF
CEEEECCHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCEEEEECCCCCHHHHHHH
RRCGVVCFSSNYELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVHNCRDLTDFGRE
HHCCEEEECCCCEEEECHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCCHHHHHHHHHH
ICATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQTGGVVDLSNLERQRKLMSALPVD
HHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCHH
EVWGIGRRISKKLDAMGIKTVLDLADSDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAP
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC
TKQEIICSRSFGERITDYPSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFAFNEP
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
YYGNSASVKLLTPTQDSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFD
CCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHCCHHEEEEEC
DNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPCYTTRSSDLLRVK
CCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]