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The map label for this gene is dmsA [H]

Identifier: 218688737

GI number: 218688737

Start: 947452

End: 949896

Strand: Direct

Name: dmsA [H]

Synonym: ECED1_0924

Alternate gene names: 218688737

Gene position: 947452-949896 (Clockwise)

Preceding gene: 218688736

Following gene: 218688738

Centisome position: 18.19

GC content: 52.02

Gene sequence:

>2445_bases
ATGAAAACGAAAATCCCTGATGCGGTATTGGCTGCTGAGGTGAGTCGCCGTGGTTTGGTAAAAACGACAGCGATCGGCGG
CCTGGCAATGGCCAGCAGCGCATTAACATTACCTTTTAGTCGGATTGCGCACGCTGTCGATAGCGCTATTCCAACAAAAT
CAGACGAAAAGGTTATCTGGAGCGCCTGTACAGTTAACTGTGGTAGTCGCTGCCCGCTACGTATGCACGTAGTGGACGGT
GAAATCAAATATGTCGAAACGGACAATACCGGCGATGACAATTACGACGGCCTGCACCAGGTTCGCGCCTGTCTGCGTGG
GCGTTCCATGCGTCGCCGTGTCTACAATCCGGACCGCCTGAAATATCCGATGAAACGAGTCGGGGCGCGCGGTGAAGGCA
AATTCGAGCGCATTAGCTGGGAAGAAGCCTACGACATCATCGCGACCAAAATGCAGCGCCTGATCAAAGAGTACGGCAAC
GAGTCTATCTATCTGAACTATGGCACCGGTACGCTGGGCGGCACCATGACCCGCTCGTGGCCGCCGGGAAATACCCTGGT
CGCGCGGCTAATGAACTGCTGCGGCGGTTATCTGAACCATTATGGCGACTACTCCTCCGCGCAAATTGCGGAAGGTCTGA
ACTATACCTACGGCGGCTGGGCAGATGGTAACAGCCCGTCGGATATCGAAAACAGTAAACTGGTAGTGCTGTTTGGTAAT
AACCCTGGCGAAACGCGAATGAGTGGCGGTGGGGTGACTTACTATCTTGAACAGGCGCGCCAGAAATCTAATGCTCGCAT
GATCATCATCGATCCGCGCTATACCGACACCGGTGCCGGGCGTGAAGATGAGTGGATCCCTATTCGTCCGGGAACAGATG
CCGCACTGGTTAACGGTCTGGCGTATGTCATGATCACCGAAAACCTGGTAGATCAGGAATTCCTCGATAAATATTGCGTT
GGCTACGACGAGAAAACCCTGCCAGCCAGTGCGCCGAAAAATGGTCACTATAAAGCTTATATTCTGGGTGAAGGACCCGA
TGGCGTGGCTAAAACACCGGAATGGGCCTCGCAAATCACCGGTGTTCCGGCAGACAAAATCATCAAACTGGCTCGTGAAA
TCGGCAGTACCAAACCGGCGTTTATCAGCCAGGGATGGGGCCCGCAGCGTCATGCTAACGGTGAAATCGCAACCCGTGCT
ATCTCGATGCTGGCGATTCTGACCGGTAACGTTGGTATTAACGGGGGGAACAGCGGCGCGCGCGAAGGTTCATACAGCTT
ACCGTTTGTCCGTATGCCGACTCTCGAAAACCCGATCCAGACCAGCATTTCTATGTTTATGTGGACCGATGCCATTGAAC
GTGGCCCGGAAATGACGGCGCTGCGTGATGGTGTGCGCGGGAAAGATAAGCTGGATGTGCCGATCAAAATGATCTGGAAC
TATGCCGGTAACTGCCTGATTAATCAGCATTCTGAAATCAACCGTACCCATGAAATCCTTCAGGATGATAAGAAGTGCGA
GCTGATTGTGGTTATCGACTGCCACATGACCTCATCGGCGAAATATGCTGACATCCTGCTGCCTGACTGCACCGCTTCCG
AACAGATGGACTTTGCACTGGATGCATCCTGCGGGAATATGTCTTACGTTATTTTCAATGATCAGGTCATTAAACCGCGC
TTTGAATGTAAGACTATCTATGAGATGACCAGCGAACTGGCAAAACGTCTTGGCGTCGAACAACAGTTTACTGAAGGTCG
TACTCAGGAAGAGTGGATGCGGCATCTGTATGCCCAGTCGCGGGAAGCGATTCCTGAACTGCCAACGTTTGAAGAGTTCC
GTAAGCAGGGGATCTTTAAAAAGCGCGATCCGCAAGGGCATCACGTTGCTTACAAAGCCTTCCGTGAAGATCCGCAGGCT
AATCCATTGACCACGCCATCGGGCAAAATTGAGATCTATTCACAGGCGCTGGCTGACATTGCCGCTACCTGGGAATTGCC
AGAAGGTGATGTGATCGATCCACTGCCGATCTATACGCCGGGCTTTGAAAGTTATCAGGATCCGCTGAACAAACAGTATC
CGCTGCAGCTTACGGGTTTCCACTATAAATCTCGCGTTCACTCAACTTACGGCAACGTTGATGTGCTGAAAGCAGCTTGC
CGTCAGGAAATGTGGATCAACCCGCTTGATGCGCAAAAACGCGGTATCAGCAACGGCGATAAAGTCAGGATCTTTAATGA
TCGTGGTGAGGTTCATATTGAGGCGAAAGTGACGCCACGAATGATGCCGGGTGTGGTCGCACTGGGTGAAGGTGCCTGGT
ATGACCCGGATACAAAACGTGTCGATAAGGGCGGTTGTATTAACGTACTGACCACTCAACGTCCGTCTCCTCTTGCCAAG
GGGAATCCATCACATACGAACCTTGTTCAGGTTGAAAAGGTGTAA

Upstream 100 bases:

>100_bases
ATTCGATGTATACAAGCCTATATAGCGATCTGCTATAGAAATAATTACACAATACGGTTTGTTACTGGAATCAATCGTGA
GCAAGCTTGAGTGAGCCATT

Downstream 100 bases:

>100_bases
GGAGTAACCGATGACAACCCAGTATGGATTTTTTATTGATTCCAGCCGTTGCACCGGTTGCAAAACCTGCGAGCTGGCTT
GTAAAGACTACAAAGATTTG

Product: dimethyl sulfoxide reductase, anaerobic subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 814; Mature: 814

Protein sequence:

>814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSALTLPFSRIAHAVDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATKMQRLIKEYGN
ESIYLNYGTGTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITENLVDQEFLDKYCV
GYDEKTLPASAPKNGHYKAYILGEGPDGVAKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAAC
RQEMWINPLDAQKRGISNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDTKRVDKGGCINVLTTQRPSPLAK
GNPSHTNLVQVEKV

Sequences:

>Translated_814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSALTLPFSRIAHAVDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATKMQRLIKEYGN
ESIYLNYGTGTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITENLVDQEFLDKYCV
GYDEKTLPASAPKNGHYKAYILGEGPDGVAKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAAC
RQEMWINPLDAQKRGISNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDTKRVDKGGCINVLTTQRPSPLAK
GNPSHTNLVQVEKV
>Mature_814_residues
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSALTLPFSRIAHAVDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDG
EIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATKMQRLIKEYGN
ESIYLNYGTGTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGN
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITENLVDQEFLDKYCV
GYDEKTLPASAPKNGHYKAYILGEGPDGVAKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRA
ISMLAILTGNVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
YAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPR
FECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQA
NPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAAC
RQEMWINPLDAQKRGISNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDTKRVDKGGCINVLTTQRPSPLAK
GNPSHTNLVQVEKV

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=814, Percent_Identity=99.5085995085995, Blast_Score=1692, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=805, Percent_Identity=67.2049689440994, Blast_Score=1150, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=818, Percent_Identity=65.4034229828851, Blast_Score=1133, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=761, Percent_Identity=32.0630749014455, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI145693196, Length=757, Percent_Identity=31.9682959048877, Blast_Score=305, Evalue=8e-84,
Organism=Escherichia coli, GI87081994, Length=752, Percent_Identity=31.3829787234043, Blast_Score=277, Evalue=3e-75,
Organism=Escherichia coli, GI3868721, Length=783, Percent_Identity=24.904214559387, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI3868720, Length=468, Percent_Identity=26.0683760683761, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1788534, Length=837, Percent_Identity=23.1780167264038, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI3868719, Length=464, Percent_Identity=24.7844827586207, Blast_Score=97, Evalue=6e-21,
Organism=Escherichia coli, GI1787477, Length=350, Percent_Identity=24.5714285714286, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1787741, Length=309, Percent_Identity=24.5954692556634, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 90452; Mature: 90452

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSALTLPFSRIAHAVDSAIPTKSDEKVIW
CCCCCCHHHHHHHHHHCCCEEHHHHCHHHHHCCHHCCCHHHHHHHHHHHCCCCCCCEEEE
SACTVNCGSRCPLRMHVVDGEIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRL
EEEECCCCCCCCEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCHHH
KYPMKRVGARGEGKFERISWEEAYDIIATKMQRLIKEYGNESIYLNYGTGTLGGTMTRSW
CCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
PPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGN
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECC
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGL
CCCCCEECCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHCCE
AYVMITENLVDQEFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGVAKTPEWASQIT
EEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHC
GVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGA
CCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
REGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHH
YAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMTSSAKYADILLPDCTASEQMDFAL
CCCCEEEECCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCEEE
DASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYAQS
ECCCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHH
REAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQALADI
HHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHH
AATWELPEGDVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAAC
HHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHH
RQEMWINPLDAQKRGISNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDTKR
HHHHCCCCCCHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCC
VDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV
CCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSALTLPFSRIAHAVDSAIPTKSDEKVIW
CCCCCCHHHHHHHHHHCCCEEHHHHCHHHHHCCHHCCCHHHHHHHHHHHCCCCCCCEEEE
SACTVNCGSRCPLRMHVVDGEIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRL
EEEECCCCCCCCEEEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHCHHHHHHCCCCHHH
KYPMKRVGARGEGKFERISWEEAYDIIATKMQRLIKEYGNESIYLNYGTGTLGGTMTRSW
CCCHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCC
PPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGN
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECC
NPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGL
CCCCCEECCCCEEHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEECCCCCCHHHHCCE
AYVMITENLVDQEFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGVAKTPEWASQIT
EEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHC
GVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGA
CCCHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
REGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWN
CCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHH
YAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMTSSAKYADILLPDCTASEQMDFAL
CCCCEEEECCHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCEEE
DASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYAQS
ECCCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHH
REAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQALADI
HHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHH
AATWELPEGDVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAAC
HHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEECCHHHHHHHHCCCCHHHHHHHH
RQEMWINPLDAQKRGISNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDTKR
HHHHCCCCCCHHHCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCC
VDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV
CCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]