Click here to switch to the map view.

The map label for this gene is lpxB [H]

Identifier: 218688057

GI number: 218688057

Start: 208123

End: 209271

Strand: Direct

Name: lpxB [H]

Synonym: ECED1_0188

Alternate gene names: 218688057

Gene position: 208123-209271 (Clockwise)

Preceding gene: 218688056

Following gene: 218688058

Centisome position: 4.0

GC content: 53.79

Gene sequence:

>1149_bases
ATGACTGAACAGCGTCCATTAACGATTGCCCTGGTCGCCGGAGAAACCTCCGGCGATATCCTGGGGGCCGGTTTAATCCG
CGCTCTGAAAGAACGTGTGCCCAACGCCCGCTTTGTTGGTGTTGCCGGGCCACGAATGCAGGCTGAAGGCTGCGAAGCCT
GGTACGAAATGGAAGAACTGGCAGTGATGGGCATTGTTGAAGTGCTCGGTCGTCTGCGTCGCTTACTACATATTCGTGCC
GATCTGACAAAGCGTTTTGGCGAACTGAAGCCAGATGTTTTTGTTGGTATTGATGCGCCTGACTTCAATATTACTCTTGA
AGGTAACCTCAAAAAGCAGGGTATCAAAACCATTCATTACGTCAGTCCGTCCGTCTGGGCGTGGCGACAGAAACGCGTTT
TCAAAATAGGCAGAGCCACCGATCTGGTGCTCGCATTTCTGCCTTTCGAAAAGGCGTTTTATGACAAATACAACGTACCG
TGCCGCTTTATCGGTCATACCATGGCTGATGCCATGCCATTAGATCCAGATAAAAATGGTGCCCGTGATGTGCTGGGGAT
CCCTTACGATGCCCACTGTCTGGCATTGTTGCCGGGCAGCCGTGGTGCAGAAGTCGAAATGCTTAGTGCCGATTTCTTGA
AAACGGCCCAGCTTTTGCGCCAGACATATCCGGATCTCGAAATCGTGGTGCCGCTGGTGAATGCCAAACGCCGCGAGCAG
TTTGAACGCATCAAAGCTGCAGTCGCGCCAGACCTGTCGGTTCATTTGCTGGATGGAATGGGCCGTGAGGCGATGGTCGC
CAGTGATGCGGCGCTACTGGCGTCGGGTACGGCAGCACTGGAGTGTATGCTGGCTAAATGCCCGATGGTAGTTGGATATC
GCATGAAGCCTTTCACCTTCTGGCTGGCGAAGCGACTGGTGAAAACTGATTATGTCTCGCTGCCAAATCTGCTGGCGGGC
AGAGAGTTAGTCAAAGAGCTATTGCAGGAAGAGTGTGAGCCGCAAAAATTGGCTGCGGCGCTGTTACCGCTGTTGGCGAA
CGGGAAAACCAGCCATGCGATGCACGACACCTTCCGCGAGCTGCATCAGCAGATCCGCTGCAATGCCGATGAGCAGGCGG
CACAAGCCGTTCTGGAGTTAGCACAATGA

Upstream 100 bases:

>100_bases
ATGAAGTGAAACCGGAAATTGCTGAACTGGCGGAAACATATCCGGAAGTGAAAGCCTTTACCGATTTCTTTGCACGCTCA
ACGCGCGGTCTGATTCGTTA

Downstream 100 bases:

>100_bases
TCGAATTTGTCTATCCGCACACGCAGCTGGTTGCGGGTGTGGATGAAGTCGGACGCGGGCCGTTAGTTGGCGCGGTCGTC
ACCGCTGCGGTGATCCTTGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRA
DLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVP
CRFIGHTMADAMPLDPDKNGARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQ
FERIKAAVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAG
RELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ

Sequences:

>Translated_382_residues
MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRA
DLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVP
CRFIGHTMADAMPLDPDKNGARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQ
FERIKAAVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAG
RELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ
>Mature_381_residues
TEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRAD
LTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPC
RFIGHTMADAMPLDPDKNGARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQF
ERIKAAVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGR
ELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRELHQQIRCNADEQAAQAVLELAQ

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=382, Percent_Identity=98.9528795811518, Blast_Score=774, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42356; Mature: 42225

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEEL
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHH
AVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEE
VSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
ARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQ
CCCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHH
FERIKAAVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTF
HHHHHHHHCCCCEEEEECCCCCCHHHHCCHHHHHCCHHHHHHHHHHCCHHHCCCCCHHHH
WLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
LHQQIRCNADEQAAQAVLELAQ
HHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TEQRPLTIALVAGETSGDILGAGLIRALKERVPNARFVGVAGPRMQAEGCEAWYEMEEL
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHH
AVMGIVEVLGRLRRLLHIRADLTKRFGELKPDVFVGIDAPDFNITLEGNLKKQGIKTIHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEE
VSPSVWAWRQKRVFKIGRATDLVLAFLPFEKAFYDKYNVPCRFIGHTMADAMPLDPDKNG
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
ARDVLGIPYDAHCLALLPGSRGAEVEMLSADFLKTAQLLRQTYPDLEIVVPLVNAKRREQ
CCCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEHHCCHHHHH
FERIKAAVAPDLSVHLLDGMGREAMVASDAALLASGTAALECMLAKCPMVVGYRMKPFTF
HHHHHHHHCCCCEEEEECCCCCCHHHHCCHHHHHCCHHHHHHHHHHCCHHHCCCCCHHHH
WLAKRLVKTDYVSLPNLLAGRELVKELLQEECEPQKLAAALLPLLANGKTSHAMHDTFRE
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHH
LHQQIRCNADEQAAQAVLELAQ
HHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA