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The map label for this gene is ggt [H]

Identifier: 218550708

GI number: 218550708

Start: 3487507

End: 3489318

Strand: Reverse

Name: ggt [H]

Synonym: EFER_3419

Alternate gene names: 218550708

Gene position: 3489318-3487507 (Counterclockwise)

Preceding gene: 218550710

Following gene: 218550705

Centisome position: 76.04

GC content: 53.75

Gene sequence:

>1812_bases
ATGATTAATTCAGAGTTATATACCAGGCTTAGCTGGGGTTGCCCCACTCATAACTGGAGAATAACGATGATAAAACCGAC
GTTTTTACGCCGGGTGGCCATTGCTACTTTGCTTTCAGGATGTTGTTTTAGTGCTGTCGCCGCGCCACCTGCGCCGCCGC
CCGTTTCATATGGTGTGGAGGAGGATGTCTTCCATCCGGTACGCGCGAAGCAGGGGATGGTGGCTTCTGTGGACGCCACT
GCCACTCAGGTGGGGGTAGATATCCTTAAGGAGGGTGGGAATGCCGTTGATGCCGCCGTGGCCGTGGGGTATGCGCTGGC
GGTAACGCATCCGCAGGCGGGGAATCTGGGCGGCGGTGGTTTTATGCTGATCCGCTCGAAAAATGGCAATACCACCGCTA
TCGATTTCCGCGAAATGGCGCCAGCCAAAGCAACACGCGATATGTTCCTCGATGACCAGGGCAACCCGGACAGCAAAAAA
TCACTCACTTCGCATCTGGCTTCCGGCACACCCGGTACGGTAGCGGGCTTCTCGTTGGCGCTGGAGAAATACGGCACCAT
GCCGTTGAATAAAGTGGTGCAACCGGCGTTTAAACTGGCACGCGATGGTTTTATTGTTAACGACGCGCTGGCTGACGATC
TCAAAACCTACGGCAGTGAAGTGCTACCAAATCACGAAAACAGCAAAGCTATCTTCTGGAAAGAGGGCGAACCGCTGAAA
AAGGGCGACAAGCTGGTACAGACGAATCTGGCAAAGAGCCTGGAGATGATTGCCGAAAACGGCCCGGATGAATTCTACAA
AGGCACGATAGCGGAACAAATCGCCCTGGAGATGCAGAAAAACGGTGGCTTGATCACTAAAGAAGATTTAGCGGCCTATA
AAGCGGTCGAACGTACACCAATAAGTGGCGATTATCGCGGGTATCAGGTTTACTCCATGCCACCGCCATCCTCCGGCGGG
ATCCATATCGTGCAGATCCTCAATATTCTGGAAAACTTCGATATGCAGAAATACGGCTTTGGCAGCGCCGACGCGATGCA
AATCATGGCAGAAGCGGAGAAACATGCCTACGCCGATCGCTCGGAATATCTTGGCGACCCGGATTTTGTCAAAGTACCGT
GGCAGGCGCTGACCAATAAAGCCTATGCCAAATCTATTGCCGATCAAATCGATATCAATAAAGCGAAGCCATCCAGCGAA
ATTCGTCCTGGCAAGCTTGCGCCTTATGAGAGTAATCAAACTACCCATTACTCAGTGGTGGATAAAGACGGTAACGCCGT
GGCGGTGACCTATACGCTGAACACCACCTTCGGTACGGGCATTGTCGCGGGCGAGAGCGGTATTTTGCTCAATAACCAGA
TGGATGATTTCTCCGCCAAACCAGGCGTACCGAACGTTTACGGGCTGGTGGGCGGCGATGCCAACGCCGTCGGGCCGAAT
AAACGCCCGCTGTCGTCGATGTCACCAACCATTGTGGTCAAGGATGGTAAAACCTGGCTGGTCACCGGAAGCCCAGGCGG
TAGCCGGATTATCACCACTGTGCTGCAAATGGTGGTGAACAGCATCGATTATGGCATGAATGTCGCCGAAGCGACCAATG
TGCCGCGTTTCCACCATCAGTGGCTGCCGGACGAGCTGCGTGTCGAGAAAGGATTTAGCCCGGATACGCTCAAGCTGCTG
GAAGCAAAAGGTCAGAAAGTGGCGCTAAAAGAGGCGATGGGCAGTACGCAAAGTATTATGGTTGGGCCGGACGGTGAGTT
GTACGGTGCATCCGACCCGCGCTCGGTGGATGATTTAACGGCGGGGTACTAA

Upstream 100 bases:

>100_bases
AGCCGACAAACGGCAGGAGTGCCGTCAAAAGCAGAAGTCGTTTCATCGCGTATCCTCCTCTGAAGATATCCTTTAAGTTT
ACTCGCTTCCCGGCAAAACG

Downstream 100 bases:

>100_bases
GGTTAGCGGCCCTCTTCGTGGGAAGAGGGCCGTATTGTCAGGGCAAGCCGAAGGTAGCTTTTTTTATTTCATAATCCTGT
AGATATTCTTCCAGCGGCTT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MINSELYTRLSWGCPTHNWRITMIKPTFLRRVAIATLLSGCCFSAVAAPPAPPPVSYGVEEDVFHPVRAKQGMVASVDAT
ATQVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKK
SLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLK
KGDKLVQTNLAKSLEMIAENGPDEFYKGTIAEQIALEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGG
IHIVQILNILENFDMQKYGFGSADAMQIMAEAEKHAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSE
IRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPN
KRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNVPRFHHQWLPDELRVEKGFSPDTLKLL
EAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY

Sequences:

>Translated_603_residues
MINSELYTRLSWGCPTHNWRITMIKPTFLRRVAIATLLSGCCFSAVAAPPAPPPVSYGVEEDVFHPVRAKQGMVASVDAT
ATQVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKK
SLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLK
KGDKLVQTNLAKSLEMIAENGPDEFYKGTIAEQIALEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGG
IHIVQILNILENFDMQKYGFGSADAMQIMAEAEKHAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSE
IRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPN
KRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNVPRFHHQWLPDELRVEKGFSPDTLKLL
EAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
>Mature_603_residues
MINSELYTRLSWGCPTHNWRITMIKPTFLRRVAIATLLSGCCFSAVAAPPAPPPVSYGVEEDVFHPVRAKQGMVASVDAT
ATQVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKK
SLTSHLASGTPGTVAGFSLALEKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLK
KGDKLVQTNLAKSLEMIAENGPDEFYKGTIAEQIALEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGG
IHIVQILNILENFDMQKYGFGSADAMQIMAEAEKHAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSE
IRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPN
KRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNVPRFHHQWLPDELRVEKGFSPDTLKLL
EAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI73915090, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI73915096, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI73915094, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=7e-69,
Organism=Homo sapiens, GI113429324, Length=521, Percent_Identity=31.6698656429942, Blast_Score=239, Evalue=7e-63,
Organism=Homo sapiens, GI113429326, Length=530, Percent_Identity=30.9433962264151, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=31.6939890710383, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI153266901, Length=551, Percent_Identity=28.3121597096189, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI153266885, Length=552, Percent_Identity=28.2608695652174, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI153266907, Length=548, Percent_Identity=26.8248175182482, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=33.7899543378995, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=33.7899543378995, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=32.4200913242009, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=30.5936073059361, Blast_Score=94, Evalue=6e-19,
Organism=Escherichia coli, GI1789856, Length=581, Percent_Identity=97.934595524957, Blast_Score=1142, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72000294, Length=551, Percent_Identity=34.1197822141561, Blast_Score=256, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI212646519, Length=551, Percent_Identity=34.1197822141561, Blast_Score=256, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI193208245, Length=558, Percent_Identity=32.7956989247312, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI193208247, Length=558, Percent_Identity=32.7956989247312, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=499, Percent_Identity=35.8717434869739, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17506189, Length=557, Percent_Identity=31.0592459605027, Blast_Score=235, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.9909706546275, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI72001497, Length=233, Percent_Identity=27.0386266094421, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI72001495, Length=232, Percent_Identity=25.8620689655172, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=497, Percent_Identity=28.169014084507, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI161077880, Length=544, Percent_Identity=32.7205882352941, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI45551474, Length=544, Percent_Identity=32.7205882352941, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24642670, Length=544, Percent_Identity=32.7205882352941, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24642666, Length=544, Percent_Identity=32.7205882352941, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI161077878, Length=544, Percent_Identity=32.7205882352941, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=31.2977099236641, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=31.0810810810811, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=28.4936479128857, Blast_Score=189, Evalue=7e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 64677; Mature: 64677

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSELYTRLSWGCPTHNWRITMIKPTFLRRVAIATLLSGCCFSAVAAPPAPPPVSYGVE
CCCHHHHHHEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGG
HHHCCCHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCE
FMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLA
EEEEECCCCCEEEEEHHHCCCCHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHH
LEKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLK
HHHHCCCCHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCH
KGDKLVQTNLAKSLEMIAENGPDEFYKGTIAEQIALEMQKNGGLITKEDLAAYKAVERTP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCC
ISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMQKYGFGSADAMQIMAEAEKHAYADR
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCH
SEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVV
HHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPN
ECCCCEEEEEEEEECCCCCEEEECCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCC
KRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNVPRFHHQ
CCCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHC
WLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLT
CCCHHHHHHCCCCCHHHHHHHHCCCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHC
AGY
CCC
>Mature Secondary Structure
MINSELYTRLSWGCPTHNWRITMIKPTFLRRVAIATLLSGCCFSAVAAPPAPPPVSYGVE
CCCHHHHHHEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
EDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGG
HHHCCCHHHCCCCEEECCCHHHHHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCE
FMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLA
EEEEECCCCCEEEEEHHHCCCCHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHH
LEKYGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLK
HHHHCCCCHHHHHHHHHHHHHCCEEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCH
KGDKLVQTNLAKSLEMIAENGPDEFYKGTIAEQIALEMQKNGGLITKEDLAAYKAVERTP
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCC
ISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMQKYGFGSADAMQIMAEAEKHAYADR
CCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHCCH
SEYLGDPDFVKVPWQALTNKAYAKSIADQIDINKAKPSSEIRPGKLAPYESNQTTHYSVV
HHHCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DKDGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPN
ECCCCEEEEEEEEECCCCCEEEECCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCC
KRPLSSMSPTIVVKDGKTWLVTGSPGGSRIITTVLQMVVNSIDYGMNVAEATNVPRFHHQ
CCCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHC
WLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLT
CCCHHHHHHCCCCCHHHHHHHHCCCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHC
AGY
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]