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The map label for this gene is envR [H]

Identifier: 218550548

GI number: 218550548

Start: 3328979

End: 3329638

Strand: Reverse

Name: envR [H]

Synonym: EFER_3243

Alternate gene names: 218550548

Gene position: 3329638-3328979 (Counterclockwise)

Preceding gene: 218550557

Following gene: 218550535

Centisome position: 72.56

GC content: 43.33

Gene sequence:

>660_bases
ATGGCGAAGAAAACGAAGGCTGATGCCCTTAAAACCAGACAACATTTGATTGAAACGGCAATTGTGCAGTTTGCTCTGCG
TGGAGTAAGCAACACAACGCTGAATGACATCGCCGATGCCGCAAGGGTTACGCGGGGAGCTATCTATTGGCATTTTGAGA
ACAAAACGCAGTTGTTCAATGAGGTGTGGGCGCAGCAACCAGCGTTACGTGAGTTGATTCAAGACAAGCTCCTGGTTCAC
GATGCAGAAAGCCCCCTGGAACAACTTCGGGAGCAGCTCATCGTTGGTCTGCAGTATATTGCTGAAATACCAAGGCAGCA
GGCGTTATTACAAATTCTGTTTCATAAATGTGAATTTAATGAAGAGATGATATCAGAACAGGAAATAAGGGAGAAAATGG
GGTTTAACCTTCACACTCTGCGGCAAACGTTACAAAAAAGTATGGCGAAGGGAGAGATCGCAAATCAACTTGATTTAGAC
GTAATGGTTATTGTGATTTATGGGGCGTTTAGCGGCATTGTTAAAAACTGGTTGATAAATCCAACGGGATATAACCTGTA
TCAGCAGGCTCCCGTATTAGTTGATAACGTGTTACGGATGCTTATGGCAGATCATAATAAAACTTCATACATCCATGATG
TGAATATATCACTCGCATGA

Upstream 100 bases:

>100_bases
GAGAGGCTCGTTTAATTCTACGGTAAATGATAAATTTGCCCCTTATTCTTTCCGCTAACAACGGAATACTGTCTCCTGTG
ATAACTCTGCAAATAAAATT

Downstream 100 bases:

>100_bases
TTTATTAATCATATTTATTAGTCAAGTTCAGAACAGTTCACCAGCTTAAGTGGATTCACAGAGTTCATATTGCGGCATTT
ATCGGCTTCAGTCGTCATTA

Product: DNA-binding transcriptional regulator EnvR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MAKKTKADALKTRQHLIETAIVQFALRGVSNTTLNDIADAARVTRGAIYWHFENKTQLFNEVWAQQPALRELIQDKLLVH
DAESPLEQLREQLIVGLQYIAEIPRQQALLQILFHKCEFNEEMISEQEIREKMGFNLHTLRQTLQKSMAKGEIANQLDLD
VMVIVIYGAFSGIVKNWLINPTGYNLYQQAPVLVDNVLRMLMADHNKTSYIHDVNISLA

Sequences:

>Translated_219_residues
MAKKTKADALKTRQHLIETAIVQFALRGVSNTTLNDIADAARVTRGAIYWHFENKTQLFNEVWAQQPALRELIQDKLLVH
DAESPLEQLREQLIVGLQYIAEIPRQQALLQILFHKCEFNEEMISEQEIREKMGFNLHTLRQTLQKSMAKGEIANQLDLD
VMVIVIYGAFSGIVKNWLINPTGYNLYQQAPVLVDNVLRMLMADHNKTSYIHDVNISLA
>Mature_218_residues
AKKTKADALKTRQHLIETAIVQFALRGVSNTTLNDIADAARVTRGAIYWHFENKTQLFNEVWAQQPALRELIQDKLLVHD
AESPLEQLREQLIVGLQYIAEIPRQQALLQILFHKCEFNEEMISEQEIREKMGFNLHTLRQTLQKSMAKGEIANQLDLDV
MVIVIYGAFSGIVKNWLINPTGYNLYQQAPVLVDNVLRMLMADHNKTSYIHDVNISLA

Specific function: Potential regulator protein for the acrEF/envCD genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789664, Length=215, Percent_Identity=71.1627906976744, Blast_Score=318, Evalue=2e-88,
Organism=Escherichia coli, GI1786669, Length=207, Percent_Identity=36.7149758454106, Blast_Score=128, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 25110; Mature: 24979

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKTKADALKTRQHLIETAIVQFALRGVSNTTLNDIADAARVTRGAIYWHFENKTQLFN
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEEEECCHHHHHH
EVWAQQPALRELIQDKLLVHDAESPLEQLREQLIVGLQYIAEIPRQQALLQILFHKCEFN
HHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
EEMISEQEIREKMGFNLHTLRQTLQKSMAKGEIANQLDLDVMVIVIYGAFSGIVKNWLIN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PTGYNLYQQAPVLVDNVLRMLMADHNKTSYIHDVNISLA
CCCCCHHHHCHHHHHHHHHHHHHCCCCCCEEEEECEEEC
>Mature Secondary Structure 
AKKTKADALKTRQHLIETAIVQFALRGVSNTTLNDIADAARVTRGAIYWHFENKTQLFN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCEEEEEECCHHHHHH
EVWAQQPALRELIQDKLLVHDAESPLEQLREQLIVGLQYIAEIPRQQALLQILFHKCEFN
HHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
EEMISEQEIREKMGFNLHTLRQTLQKSMAKGEIANQLDLDVMVIVIYGAFSGIVKNWLIN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PTGYNLYQQAPVLVDNVLRMLMADHNKTSYIHDVNISLA
CCCCCHHHHCHHHHHHHHHHHHHCCCCCCEEEEECEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]