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The map label for this gene is dsbG [H]

Identifier: 218549807

GI number: 218549807

Start: 2550796

End: 2551602

Strand: Direct

Name: dsbG [H]

Synonym: EFER_2489

Alternate gene names: 218549807

Gene position: 2550796-2551602 (Clockwise)

Preceding gene: 218549804

Following gene: 218549808

Centisome position: 55.59

GC content: 44.11

Gene sequence:

>807_bases
ATGACAGTGATAGGTTATGCCTTTTACTTCATTTTTGCACTGACTGAAAAGGATAAATTAATGTTAAAAAAGTCACTTTT
AATGACAATGTTACCTGCCATCGCCTTCGCACAGGAGTTACCAGAAGCAGTTAAAGCAATTGAAAAACAAGGCATTACCA
TAATAAAACCTTTCGACGCCCCCGGCGGCATGAAAGGCTATCTGGGGAAATATCAGGATATGGGCGTCACCATCTATCTG
ACCCCCGATGGTAAGCATGCTATCTCCGGCTACATGTACAACGAAAAAGGTGAAAACCTGAGCAATACACTTATCGAAAA
AGAAATTTATGCGCCAGCCGGACGCGAAATGTGGCAACGGATGGAACAATCGCACTGGCTCCTCGACGGTAAAAAAGACG
CGCCAGTCATAGTCTACGTTTTCGCCGATCCGTTCTGTCCTTATTGCAAACAATTCTGGAAACAGACGCGCCCCTGGGTA
GAGTCGGGTAAAGTACAACTAAGAACCTTACTGGTCGGCGTCATCAAACCAGAAAGTCCTGCTACAGCAGCAGCTATTCT
CGCCAGTAAAGATCCCGCCAGCACCTGGAGTAAATACGAATCTTCAGAAGGTAAATTGCAACTGAATGTGACTGCTAATA
TTACGTCGGAGCAGATGAAAACTCTGAAAGATAATGAAAAGTTGATGGATGATCTAGGGGCCAATGTCACACCTGCAATC
TATTACATGAGCAAAGACAACACTCTGCAACAAGCGGTAGGTTTGCCAGATAATAAAACGCTTAATACCATTATGGGCGA
GGAATAA

Upstream 100 bases:

>100_bases
CTGCCTGCAGGCTGTGGTGTTGCCCTTGCAAATGCAACAACGACATGGATTACAACACCCTCATAAACAAAGGGCAATCA
CCTGATCTAAGCTCTTACCT

Downstream 100 bases:

>100_bases
ATATCACCGATGAGTAGCTGATTTTTTATTAACATATCGGTTACTCATACACGCATTATTTGTACATCAGTCATAGAGAA
CTGTGTTATTTTAGCGCCGC

Product: disulfide isomerase/thiol-disulfide oxidase

Products: protein with oxidized disulfide bonds [C]

Alternate protein names: NA

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MTVIGYAFYFIFALTEKDKLMLKKSLLMTMLPAIAFAQELPEAVKAIEKQGITIIKPFDAPGGMKGYLGKYQDMGVTIYL
TPDGKHAISGYMYNEKGENLSNTLIEKEIYAPAGREMWQRMEQSHWLLDGKKDAPVIVYVFADPFCPYCKQFWKQTRPWV
ESGKVQLRTLLVGVIKPESPATAAAILASKDPASTWSKYESSEGKLQLNVTANITSEQMKTLKDNEKLMDDLGANVTPAI
YYMSKDNTLQQAVGLPDNKTLNTIMGEE

Sequences:

>Translated_268_residues
MTVIGYAFYFIFALTEKDKLMLKKSLLMTMLPAIAFAQELPEAVKAIEKQGITIIKPFDAPGGMKGYLGKYQDMGVTIYL
TPDGKHAISGYMYNEKGENLSNTLIEKEIYAPAGREMWQRMEQSHWLLDGKKDAPVIVYVFADPFCPYCKQFWKQTRPWV
ESGKVQLRTLLVGVIKPESPATAAAILASKDPASTWSKYESSEGKLQLNVTANITSEQMKTLKDNEKLMDDLGANVTPAI
YYMSKDNTLQQAVGLPDNKTLNTIMGEE
>Mature_267_residues
TVIGYAFYFIFALTEKDKLMLKKSLLMTMLPAIAFAQELPEAVKAIEKQGITIIKPFDAPGGMKGYLGKYQDMGVTIYLT
PDGKHAISGYMYNEKGENLSNTLIEKEIYAPAGREMWQRMEQSHWLLDGKKDAPVIVYVFADPFCPYCKQFWKQTRPWVE
SGKVQLRTLLVGVIKPESPATAAAILASKDPASTWSKYESSEGKLQLNVTANITSEQMKTLKDNEKLMDDLGANVTPAIY
YMSKDNTLQQAVGLPDNKTLNTIMGEE

Specific function: Involved in disulfide bond formation. Functions probably as a disulfide isomerase with a narrower substrate specificity than DsbC. DsbG is maintained in a reduced state by DsbD. In vitro, displays chaperone activity in both redox states [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081762, Length=233, Percent_Identity=89.6995708154506, Blast_Score=442, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 30002; Mature: 29871

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIGYAFYFIFALTEKDKLMLKKSLLMTMLPAIAFAQELPEAVKAIEKQGITIIKPFDA
CEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
PGGMKGYLGKYQDMGVTIYLTPDGKHAISGYMYNEKGENLSNTLIEKEIYAPAGREMWQR
CCCCHHHCCCHHHCCEEEEECCCCCCHHCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHH
MEQSHWLLDGKKDAPVIVYVFADPFCPYCKQFWKQTRPWVESGKVQLRTLLVGVIKPESP
HHHHCEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHHCCCEEEEEEEEHEECCCCC
ATAAAILASKDPASTWSKYESSEGKLQLNVTANITSEQMKTLKDNEKLMDDLGANVTPAI
CHHHHEEECCCCHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEE
YYMSKDNTLQQAVGLPDNKTLNTIMGEE
EEEECCCHHHHHCCCCCCCCHHHHCCCC
>Mature Secondary Structure 
TVIGYAFYFIFALTEKDKLMLKKSLLMTMLPAIAFAQELPEAVKAIEKQGITIIKPFDA
EEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
PGGMKGYLGKYQDMGVTIYLTPDGKHAISGYMYNEKGENLSNTLIEKEIYAPAGREMWQR
CCCCHHHCCCHHHCCEEEEECCCCCCHHCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHH
MEQSHWLLDGKKDAPVIVYVFADPFCPYCKQFWKQTRPWVESGKVQLRTLLVGVIKPESP
HHHHCEEECCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHHCCCEEEEEEEEHEECCCCC
ATAAAILASKDPASTWSKYESSEGKLQLNVTANITSEQMKTLKDNEKLMDDLGANVTPAI
CHHHHEEECCCCHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEE
YYMSKDNTLQQAVGLPDNKTLNTIMGEE
EEEECCCHHHHHCCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: protein with reduced SH groups [C]

Specific reaction: protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]