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The map label for this gene is nagC [H]

Identifier: 218549756

GI number: 218549756

Start: 2497549

End: 2498769

Strand: Direct

Name: nagC [H]

Synonym: EFER_2433

Alternate gene names: 218549756

Gene position: 2497549-2498769 (Clockwise)

Preceding gene: 218549755

Following gene: 218549757

Centisome position: 54.43

GC content: 53.07

Gene sequence:

>1221_bases
ATGACACCAGGCGGACAAGCTCAGATAGGTAATGTTGATCTCGTAAAACAGCTTAACAGCGCGGCGGTTTATCGCCTGAT
TGACCAGTATGGGCCAATCTCGCGGATTCAGATTGCCGAGCAAAGCCAGCTTGCCCCCGCCAGCGTAACCAAGATTACGC
GTCAGCTTATCGAACGCGGGCTGATCAAAGAAGTTGATCAGCAGGCCTCCACCGGGGGCCGCCGCGCTATCTCCATTGTC
ACCGAAACCCGCAATTTCCACGCAATCGGCGTACGGCTTGGTCGTCATGACGCCACCATCACATTGTTTGATCTCAGTAG
CAAAGTGTTGGCAGAAGAACATTACCCGTTGCCTGAACGCACTCAGCAAACGCTGGAACATGCCCTGCTGAATGCCATTG
CTCAGTTTATTGATAGCTACCAGCGCAAACTGCGCGAGCTGATCGCCATTTCCGTGATCCTGCCAGGGCTTGTTGACCCG
GACAGCGGCAAAATTCATTACATGCCGCATATTCAGGTAGAAAACTGGGGACTGGTAGAAGCACTGGAAGAACGTTTTAA
AGTGACCTGCTTTGTCGGCCACGATATCCGCAGTCTGGCACTGGCAGAGCACTACTTCGGTGCAAGCCAGGATTGCGAAG
ACTCAATTCTGGTGCGTGTGCATCGCGGAACCGGAGCCGGGATTATCTCTAACGGGCGCATTTTTATCGGTCGCAACGGC
AACGTCGGTGAAATTGGTCATATTCAGGTCGAACCGTTGGGGGAACGCTGCCACTGCGGCAACTTCGGCTGCCTGGAAAC
TATCGCCGCCAACGCCGCCATTGAACAGCGGGTGTTGAATCTGTTAAAGCAGGGCTACCAGAGTCGCGTGCCGCTGGACG
ACTGCACCATCAAAACTATCTGCAAAGCCGCGAACAAAGGCGACGGTCTGGCGTCGGAAGTGATTGAGTATGTCGGTCGT
CATCTGGGTAAAACCATCGCCATTGCTATCAACTTATTTAATCCGCAAAAAATTGTTATCGCTGGTGAGATCACCGAAGC
CGATAAAGTGCTGCTCCCTGCTATTGAAAGCTGCATTAATACCCAGGCGCTGAAGGCGTTTCGCACCAATCTGCCGGTGG
TACGTTCTGAGCTGGATCACCGCTCGGCAATCGGCGCTTTTGCGCTGGTAAAACGCGCCATGCTCAACGGTATTTTGCTC
CAGCATTTGCTGGAAAATTAA

Upstream 100 bases:

>100_bases
CCGCTGGTAAAGTAGCCAACCTGACTGCATTCACACCTGATTTTAAAATCACCAGGACCATCGTTAACGGTAACGAGGTC
GTAACTCAATAAGAGAAAGT

Downstream 100 bases:

>100_bases
TGTGCTTTTATAGTGGCGCTTATTGTTGTCAATATTCTGGGTAGTCCATGACCATTAAAAATGTAATTTGCGATATCGAC
GGCGTGCTGATGCACGATAA

Product: DNA-binding transcriptional dual regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTPGGQAQIGNVDLVKQLNSAAVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIV
TETRNFHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDP
DSGKIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDGLASEVIEYVGR
HLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILL
QHLLEN

Sequences:

>Translated_406_residues
MTPGGQAQIGNVDLVKQLNSAAVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIV
TETRNFHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDP
DSGKIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDGLASEVIEYVGR
HLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILL
QHLLEN
>Mature_405_residues
TPGGQAQIGNVDLVKQLNSAAVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERGLIKEVDQQASTGGRRAISIVT
ETRNFHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPERTQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPD
SGKIHYMPHIQVENWGLVEALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNGN
VGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTICKAANKGDGLASEVIEYVGRH
LGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCINTQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILLQ
HLLEN

Specific function: Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Escherichia coli, GI1786891, Length=406, Percent_Identity=99.7536945812808, Blast_Score=826, Evalue=0.0,
Organism=Escherichia coli, GI1787878, Length=400, Percent_Identity=40.5, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI87082127, Length=345, Percent_Identity=24.6376811594203, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081733, Length=272, Percent_Identity=22.7941176470588, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790522, Length=293, Percent_Identity=24.5733788395904, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR; PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 44512; Mature: 44381

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPGGQAQIGNVDLVKQLNSAAVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECHHCCCCHHHHHHHHHHHHHHH
LIKEVDQQASTGGRRAISIVTETRNFHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPER
HHHHHHHHHCCCCCEEEEEEEECCCEEEEEEEECCCCCEEEEEECCHHHHHHCCCCCCHH
TQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYMPHIQVENWGLVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCHHH
ALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
HHHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCEEEEECCC
NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTI
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
CKAANKGDGLASEVIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCIN
HHHCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHH
TQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILLQHLLEN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPGGQAQIGNVDLVKQLNSAAVYRLIDQYGPISRIQIAEQSQLAPASVTKITRQLIERG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECHHCCCCHHHHHHHHHHHHHHH
LIKEVDQQASTGGRRAISIVTETRNFHAIGVRLGRHDATITLFDLSSKVLAEEHYPLPER
HHHHHHHHHCCCCCEEEEEEEECCCEEEEEEEECCCCCEEEEEECCHHHHHHCCCCCCHH
TQQTLEHALLNAIAQFIDSYQRKLRELIAISVILPGLVDPDSGKIHYMPHIQVENWGLVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEECCCCHHH
ALEERFKVTCFVGHDIRSLALAEHYFGASQDCEDSILVRVHRGTGAGIISNGRIFIGRNG
HHHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEECCEEEEECCC
NVGEIGHIQVEPLGERCHCGNFGCLETIAANAAIEQRVLNLLKQGYQSRVPLDDCTIKTI
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
CKAANKGDGLASEVIEYVGRHLGKTIAIAINLFNPQKIVIAGEITEADKVLLPAIESCIN
HHHCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHH
TQALKAFRTNLPVVRSELDHRSAIGAFALVKRAMLNGILLQHLLEN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]