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The map label for this gene is hchA [H]

Identifier: 218549290

GI number: 218549290

Start: 1999771

End: 2000622

Strand: Direct

Name: hchA [H]

Synonym: EFER_1951

Alternate gene names: 218549290

Gene position: 1999771-2000622 (Clockwise)

Preceding gene: 218549289

Following gene: 218549291

Centisome position: 43.58

GC content: 47.54

Gene sequence:

>852_bases
ATGACTGTTCAAAAAAGTAAAAATCCGCAGATCGATGCAGCAGAAAATGATGCTTTTTTTCCTTCAGAATACTCACTAAG
TCAGTATACCAGCCCGGTATCAGACCTTGAGGGGGCCAATTACCCGAACCCCTATACAGGGCCGCAGAAGATTCTGGTTA
TCGCCGCTGATGAACGCTATCTGCCCACTGATAATGGCGCTCTGTTTTCAACGGGTAACCATCCTATTGAAACACTTCTA
CCTTTATATCATCTACATGCCGCTGGCTTTGAGTTTGAAGTCGCAACTATTTCCGGTCTGATGACGAAGTTTGAATACTG
GGCGATGCCGCACAAAGATGAAAAAGTGATGGGCTTCTTTGAGCAGCATAAGCATCTGTTCCGTAATCCGCTGAAGCTGG
CAAATGTAGTCGCAAACCTTAACGGCGATAGCCCTTACGCTGCTGTATTCATCCCCGGTGGCCACGGCGCATTAATTGGC
CTGCCTGAAAGCCCGGAAGTCGCAGCTACTTTGCAGTGGGCCATCAACAATGACCGGTTTGTTATTTCTCTTTGCCACGG
CCCTGCTGCATTTCTTTCCCTTCGTTATGGAGATAATCCACTAAACGGTTACGCAATTTGCGCCTTCCCCGATGCAGCAG
ACAAACAGACGCCAGATATCGGCTATATGCCTGGCCAACTGACGTGGTTTTTTGGTGAGGAACTGCAGAAAATGGGCATG
ACTATAGTAAATGACGATATTACTGGTCGGGTTCACAAAGATCGTAAGCTGTTAACGGGTGACAGTCCGTTTGCTGCTAA
TGCACTTGGTAAACTGGCGGCGCAGGAATTGCTGATGGCTTACAGTAATTAA

Upstream 100 bases:

>100_bases
TTTGGATAGATTGACAGCATTTTTGGGTGTTGGTAGAAATAGCGCCAACTCAGTCGCGAAGATAGTGACTAATATCCCTG
AGAAGTAATAGGAGTACACT

Downstream 100 bases:

>100_bases
TCTGACAATTATCGATAAGTTATTAATCACCAACCGCAGCCCCTGCGCTGCGGTTCAAGGTTGCTCAAAATGGTGCATCA
TATTTATTGCCCAACCAATT

Product: chaperone protein HchA

Products: NA

Alternate protein names: Hsp31 [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTVQKSKNPQIDAAENDAFFPSEYSLSQYTSPVSDLEGANYPNPYTGPQKILVIAADERYLPTDNGALFSTGNHPIETLL
PLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMGFFEQHKHLFRNPLKLANVVANLNGDSPYAAVFIPGGHGALIG
LPESPEVAATLQWAINNDRFVISLCHGPAAFLSLRYGDNPLNGYAICAFPDAADKQTPDIGYMPGQLTWFFGEELQKMGM
TIVNDDITGRVHKDRKLLTGDSPFAANALGKLAAQELLMAYSN

Sequences:

>Translated_283_residues
MTVQKSKNPQIDAAENDAFFPSEYSLSQYTSPVSDLEGANYPNPYTGPQKILVIAADERYLPTDNGALFSTGNHPIETLL
PLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMGFFEQHKHLFRNPLKLANVVANLNGDSPYAAVFIPGGHGALIG
LPESPEVAATLQWAINNDRFVISLCHGPAAFLSLRYGDNPLNGYAICAFPDAADKQTPDIGYMPGQLTWFFGEELQKMGM
TIVNDDITGRVHKDRKLLTGDSPFAANALGKLAAQELLMAYSN
>Mature_282_residues
TVQKSKNPQIDAAENDAFFPSEYSLSQYTSPVSDLEGANYPNPYTGPQKILVIAADERYLPTDNGALFSTGNHPIETLLP
LYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMGFFEQHKHLFRNPLKLANVVANLNGDSPYAAVFIPGGHGALIGL
PESPEVAATLQWAINNDRFVISLCHGPAAFLSLRYGDNPLNGYAICAFPDAADKQTPDIGYMPGQLTWFFGEELQKMGMT
IVNDDITGRVHKDRKLLTGDSPFAANALGKLAAQELLMAYSN

Specific function: Uses temperature-induced exposure of structured hydrophobic domains to capture and stabilize early unfolding protein intermediates under severe thermal stress. It rapidly releases them once stress has abated [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C56 family. HchA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788278, Length=282, Percent_Identity=86.5248226950355, Blast_Score=518, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017283
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 31057; Mature: 30926

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQKSKNPQIDAAENDAFFPSEYSLSQYTSPVSDLEGANYPNPYTGPQKILVIAADERY
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHCCCCCCCCCCCCCCEEEEEEECCCC
LPTDNGALFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMGFF
CCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHH
EQHKHLFRNPLKLANVVANLNGDSPYAAVFIPGGHGALIGLPESPEVAATLQWAINNDRF
HHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCEEEEECCCCCCEEEEEEEEECCCEE
VISLCHGPAAFLSLRYGDNPLNGYAICAFPDAADKQTPDIGYMPGQLTWFFGEELQKMGM
EEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCC
TIVNDDITGRVHKDRKLLTGDSPFAANALGKLAAQELLMAYSN
EEEECCCCCEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVQKSKNPQIDAAENDAFFPSEYSLSQYTSPVSDLEGANYPNPYTGPQKILVIAADERY
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCHHHCCCCCCCCCCCCCCEEEEEEECCCC
LPTDNGALFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMGFF
CCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHCCCCCCHHHHHHH
EQHKHLFRNPLKLANVVANLNGDSPYAAVFIPGGHGALIGLPESPEVAATLQWAINNDRF
HHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCEEEEECCCCCCEEEEEEEEECCCEE
VISLCHGPAAFLSLRYGDNPLNGYAICAFPDAADKQTPDIGYMPGQLTWFFGEELQKMGM
EEEECCCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCC
TIVNDDITGRVHKDRKLLTGDSPFAANALGKLAAQELLMAYSN
EEEECCCCCEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA