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The map label for this gene is mdtH [H]

Identifier: 218549207

GI number: 218549207

Start: 1913380

End: 1914666

Strand: Direct

Name: mdtH [H]

Synonym: EFER_1864

Alternate gene names: 218549207

Gene position: 1913380-1914666 (Clockwise)

Preceding gene: 218549202

Following gene: 218549208

Centisome position: 41.7

GC content: 49.73

Gene sequence:

>1287_bases
TTGATAGTAGGAAAAATAACAACAGCACAGCAGAATAGAAATTGCTCAACTTTGGATTTCCCGGGAGGGGAAATGGCGTG
CGTATCGCAGGCGAGGAACCTGGGTAAATATTTCCTTCTTGTTGATAATATGCTGGTGGTGCTGGGCTTCTTTGTTGTCT
TTCCGCTAATCTCCATTCGCTTCGTTGATCAGATGGGCTGGGCTGCCGTTATGGTCGGTATTGCTCTCGGCTTGCGTCAG
TTTATCCAGCAAGGGCTGGGCATTTTTGGCGGTGCAATCGCTGATCGCTTTGGTGCCAAGCCGATGATAGTAACCGGTAT
GCTTTTGCGTGCTGCCGGATTTGCCACTATGGGTATTGCCCATGAACCATGGTTACTGTGGTTTTCCTGTTTTCTTTCTG
GCCTTGGTGGCACTTTGTTTGATCCTCCTCGTTCTGCCCTGGTGGTTAAACTTATCCGTCCTGAACAGCGCGGGCGCTTC
TTTTCGCTATTAATGATGCAAGACAGTGCTGACGCAGTCATTGGGGCTTTGCTGGGAAGCTGGTTATTGCAGTACGATTT
TCGTCTGGTTTGCGCTACAGGCGCAATTTTGTTCGTTATGTGCGCTGCATTTAATGCCTGGCTGCTACCAGCATGGAAAT
TATCTACGGTTCGTGCACCTGTACGCGAAGGAATGAGCCGGGTTATGGGCGATAAACGTTTTGTAACCTATGTGCTGACA
CTGGCTGGCTACTATATGCTGGCTGTCCAGGTGATGCTGATGCTACCGATTATGGTTAACGATATTGCCGGAACACCGTC
AGCCGTAAAATGGATGTACGCTATCGAAGCGTGTCTCTCGCTAACATTGCTCTACCCTATCGCCCGTTGGAGTGAAAAAC
GTTTTCGTCTGGAGCACCGCTTAATGGCTGGCTTACTGGTGATGTCACTCAGTATGCTCCCTGTTGGGCTTGTCGGTTCT
CTTCCGCATTTATTTACGTTGATCTGTATCTTCTATATTGGATCGATTATTGCGGAACCTGCCAGGGAAACACTCAGTGC
TTCGCTGGCTGACGCCAGAGCGCGCGGAAGTTATATGGGTTTTAGCCGTCTTGGATTAGCCATTGGCGGCGCCGTGGGAT
ATATCGGTGGTGGCTGGCTGTTTGATATGGGGAAAGCACTGCAACAGCCGGAATTACCATGGATGATGTTGGGCATTATC
GGCATTATCACCTTTCTGGGGCTGGGATGGCAGTTTAGCCACAAACATACGGCCAGCAGAATGTTAGGACCTGACGCCCG
ATCTTAA

Upstream 100 bases:

>100_bases
TGCGGTGTTATCGGGAAAAATATCTTTTCTATTAATATTCACATATTTTGATAAAAACTCTCGATTAACCATGACTTTTT
GATAAAAAAATATCATCCCA

Downstream 100 bases:

>100_bases
TCCTACGTGACGAGCGTTACATGGTAAGATGCGCACCGCAGTTTGAAACACTGTGGTTTAAGTTTTTTCTGCTGGAATGT
ATTTCCCCGGTGCCCCATGC

Product: multidrug resistance protein MdtH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIVGKITTAQQNRNCSTLDFPGGEMACVSQARNLGKYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQ
FIQQGLGIFGGAIADRFGAKPMIVTGMLLRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRF
FSLLMMQDSADAVIGALLGSWLLQYDFRLVCATGAILFVMCAAFNAWLLPAWKLSTVRAPVREGMSRVMGDKRFVTYVLT
LAGYYMLAVQVMLMLPIMVNDIAGTPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPVGLVGS
LPHLFTLICIFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAVGYIGGGWLFDMGKALQQPELPWMMLGII
GIITFLGLGWQFSHKHTASRMLGPDARS

Sequences:

>Translated_428_residues
MIVGKITTAQQNRNCSTLDFPGGEMACVSQARNLGKYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQ
FIQQGLGIFGGAIADRFGAKPMIVTGMLLRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRF
FSLLMMQDSADAVIGALLGSWLLQYDFRLVCATGAILFVMCAAFNAWLLPAWKLSTVRAPVREGMSRVMGDKRFVTYVLT
LAGYYMLAVQVMLMLPIMVNDIAGTPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPVGLVGS
LPHLFTLICIFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAVGYIGGGWLFDMGKALQQPELPWMMLGII
GIITFLGLGWQFSHKHTASRMLGPDARS
>Mature_428_residues
MIVGKITTAQQNRNCSTLDFPGGEMACVSQARNLGKYFLLVDNMLVVLGFFVVFPLISIRFVDQMGWAAVMVGIALGLRQ
FIQQGLGIFGGAIADRFGAKPMIVTGMLLRAAGFATMGIAHEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRF
FSLLMMQDSADAVIGALLGSWLLQYDFRLVCATGAILFVMCAAFNAWLLPAWKLSTVRAPVREGMSRVMGDKRFVTYVLT
LAGYYMLAVQVMLMLPIMVNDIAGTPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLVMSLSMLPVGLVGS
LPHLFTLICIFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLAIGGAVGYIGGGWLFDMGKALQQPELPWMMLGII
GIITFLGLGWQFSHKHTASRMLGPDARS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081828, Length=402, Percent_Identity=90.7960199004975, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI87081738, Length=357, Percent_Identity=23.5294117647059, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR022855
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46853; Mature: 46853

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGKITTAQQNRNCSTLDFPGGEMACVSQARNLGKYFLLVDNMLVVLGFFVVFPLISIR
CEEECEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLLRAAGFATMGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHCCC
HEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSADAVIGALLGS
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHH
WLLQYDFRLVCATGAILFVMCAAFNAWLLPAWKLSTVRAPVREGMSRVMGDKRFVTYVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LAGYYMLAVQVMLMLPIMVNDIAGTPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHR
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMAGLLVMSLSMLPVGLVGSLPHLFTLICIFYIGSIIAEPARETLSASLADARARGSYMG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FSRLGLAIGGAVGYIGGGWLFDMGKALQQPELPWMMLGIIGIITFLGLGWQFSHKHTASR
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
MLGPDARS
HCCCCCCC
>Mature Secondary Structure
MIVGKITTAQQNRNCSTLDFPGGEMACVSQARNLGKYFLLVDNMLVVLGFFVVFPLISIR
CEEECEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVDQMGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLLRAAGFATMGIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHCCC
HEPWLLWFSCFLSGLGGTLFDPPRSALVVKLIRPEQRGRFFSLLMMQDSADAVIGALLGS
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHH
WLLQYDFRLVCATGAILFVMCAAFNAWLLPAWKLSTVRAPVREGMSRVMGDKRFVTYVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LAGYYMLAVQVMLMLPIMVNDIAGTPSAVKWMYAIEACLSLTLLYPIARWSEKRFRLEHR
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMAGLLVMSLSMLPVGLVGSLPHLFTLICIFYIGSIIAEPARETLSASLADARARGSYMG
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FSRLGLAIGGAVGYIGGGWLFDMGKALQQPELPWMMLGIIGIITFLGLGWQFSHKHTASR
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
MLGPDARS
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA