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The map label for this gene is ndh [H]

Identifier: 218549165

GI number: 218549165

Start: 1873777

End: 1875081

Strand: Reverse

Name: ndh [H]

Synonym: EFER_1819

Alternate gene names: 218549165

Gene position: 1875081-1873777 (Counterclockwise)

Preceding gene: 218549166

Following gene: 218549164

Centisome position: 40.86

GC content: 50.11

Gene sequence:

>1305_bases
TTGACTACGCCATTGAAAAGAATCGTGATTGTCGGCGGAGGCGCTGGCGGACTGGAACTGGCAACGCAGTTGGGTCATAA
ACTGGGGCGCAAGAAAAAAGCGAAAGTTACGCTTGTTGACAGAAACCACAGTCATTTGTGGAAGCCGCTGCTGCACGAAG
TGGCGACGGGGTCTCTGGATGAAGGAGTAGATGCCCTGAGCTACCTCGCTCATGCCCGTAATCATGGGTTTGAGTTCCAG
CTAGGCTCAGTGAAAGATATCGATCGTGAAGCGAAGACCATTACCATTGCCGAACTGCGCGATGAAAAAGGTGAATTGCT
GGTACCGGAGCGCAAAATTGCTTATGACACACTGGTCATGGCACTGGGAAGCACCTCCAACGATTTCAACACACCAGGTG
TTAAAGAGAACTGCATATTCCTTGATAACCCGCATCAGGCTCGTCGCTTTCATCAGGAGATGCTGAATCTGTTCCTGAAG
TACTCCGCTAACCTTGGCTCTAACGGCAAAGTTAATATTGCTATTGTTGGTGGTGGGGCAACCGGGGTTGAGTTATCCGC
AGAACTGCATAATGCAGTAAAACAGTTACATAGTTACGGCTACAAAGGGCTAACGAACGAAGCCCTGAACGTCACGCTGG
TTGAAGCAGGAGAGCGCATTCTGCCTGCTCTGCCGCCACGAATCTCCAGTGCCGCGCATAACGAACTGACCAAACTGGGT
GTGCGAGTGTTGACGCAAACAATGGTAACCAGCGCGGATGCTGGTGGCTTGCATACCAAAGATGGCGAATATATCGAAGC
AGACCTGATGGTTTGGGCAGCGGGCATCAAAGCACCAGATTTCCTCAAAGATATTGGTGGCCTGGAAACAAACCGTATCA
ACCAACTGGTGGTTGAGCCGACGTTGCAAACCACGCGCGATGCAGATATTTATGCAATTGGTGATTGCGCGTCCTGTGCT
CGCCCGGAAGGAGGCTTTGTACCGCCACGCGCTCAGGCGGCCCATCAAATGGCAACCTGTGCGTTACAGAATATTCTGGC
ACAAATGAACGGTAAGCCCCTGAAAAGTTACCGTTATAAAGATCATGGTTCATTGGTTTCGCTGTCAAACTTCTCGACAG
TCGGTAGCCTGATGGGCAACCTGACCAAAGGTTCTATGATGATTGAGGGGCGAATTGCTCGCTTTGTGTATATCTCGCTT
TATCGTATGCACCAGATTGCCCTTCACGGTTATTTCAAAACCGGGTTAATGATGCTGGTGGGTAGCATTAACCGCGTTAT
TCGCCCACGACTTAAACTTCATTAA

Upstream 100 bases:

>100_bases
AAATGCGAGGAACGTTTTCATTAGCGTAACCTATTGTTAATTAAAGGCTATTTTAATAACCTTTAGTTAACAATTGGTTA
ATCATTTTAAGGGGGTCACG

Downstream 100 bases:

>100_bases
TCTGCTGGTCAGACGGTGATGAGTCTGCATCACCGTCTGACTCATCACTTGAGAAGAATCTCAAACTGCGGGTGATTTTA
ACCAGCTCATCTTTTTTCAT

Product: respiratory NADH dehydrogenase 2/cupric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTTPLKRIVIVGGGAGGLELATQLGHKLGRKKKAKVTLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFEFQ
LGSVKDIDREAKTITIAELRDEKGELLVPERKIAYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLK
YSANLGSNGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISSAAHNELTKLG
VRVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEPTLQTTRDADIYAIGDCASCA
RPEGGFVPPRAQAAHQMATCALQNILAQMNGKPLKSYRYKDHGSLVSLSNFSTVGSLMGNLTKGSMMIEGRIARFVYISL
YRMHQIALHGYFKTGLMMLVGSINRVIRPRLKLH

Sequences:

>Translated_434_residues
MTTPLKRIVIVGGGAGGLELATQLGHKLGRKKKAKVTLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFEFQ
LGSVKDIDREAKTITIAELRDEKGELLVPERKIAYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLK
YSANLGSNGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISSAAHNELTKLG
VRVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEPTLQTTRDADIYAIGDCASCA
RPEGGFVPPRAQAAHQMATCALQNILAQMNGKPLKSYRYKDHGSLVSLSNFSTVGSLMGNLTKGSMMIEGRIARFVYISL
YRMHQIALHGYFKTGLMMLVGSINRVIRPRLKLH
>Mature_433_residues
TTPLKRIVIVGGGAGGLELATQLGHKLGRKKKAKVTLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFEFQL
GSVKDIDREAKTITIAELRDEKGELLVPERKIAYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKY
SANLGSNGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISSAAHNELTKLGV
RVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEPTLQTTRDADIYAIGDCASCAR
PEGGFVPPRAQAAHQMATCALQNILAQMNGKPLKSYRYKDHGSLVSLSNFSTVGSLMGNLTKGSMMIEGRIARFVYISLY
RMHQIALHGYFKTGLMMLVGSINRVIRPRLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=434, Percent_Identity=96.5437788018433, Blast_Score=856, Evalue=0.0,
Organism=Escherichia coli, GI1789065, Length=358, Percent_Identity=26.8156424581006, Blast_Score=73, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320118, Length=351, Percent_Identity=27.3504273504274, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323515, Length=461, Percent_Identity=25.8134490238612, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323794, Length=352, Percent_Identity=28.9772727272727, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47262; Mature: 47131

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLKRIVIVGGGAGGLELATQLGHKLGRKKKAKVTLVDRNHSHLWKPLLHEVATGSLD
CCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHH
EGVDALSYLAHARNHGFEFQLGSVKDIDREAKTITIAELRDEKGELLVPERKIAYDTLVM
HHHHHHHHHHHHHCCCCEEEECCCHHCCCCCCEEEEEECCCCCCCEECCCHHHHHHHHHH
ALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKYSANLGSNGKVNIAIVGGGA
HHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
TGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISSAAHNELTKLG
CCEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHH
VRVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEP
HHHHHHHHHHCCCCCCCCCCCCCEEEHEEEEEECCCCCHHHHHHHCCCCCCCCCEEEECC
TLQTTRDADIYAIGDCASCARPEGGFVPPRAQAAHQMATCALQNILAQMNGKPLKSYRYK
CHHCCCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
DHGSLVSLSNFSTVGSLMGNLTKGSMMIEGRIARFVYISLYRMHQIALHGYFKTGLMMLV
CCCCEEEECCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSINRVIRPRLKLH
HHHHHHHCCHHCCC
>Mature Secondary Structure 
TTPLKRIVIVGGGAGGLELATQLGHKLGRKKKAKVTLVDRNHSHLWKPLLHEVATGSLD
CCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHH
EGVDALSYLAHARNHGFEFQLGSVKDIDREAKTITIAELRDEKGELLVPERKIAYDTLVM
HHHHHHHHHHHHHCCCCEEEECCCHHCCCCCCEEEEEECCCCCCCEECCCHHHHHHHHHH
ALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKYSANLGSNGKVNIAIVGGGA
HHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCC
TGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISSAAHNELTKLG
CCEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHH
VRVLTQTMVTSADAGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEP
HHHHHHHHHHCCCCCCCCCCCCCEEEHEEEEEECCCCCHHHHHHHCCCCCCCCCEEEECC
TLQTTRDADIYAIGDCASCARPEGGFVPPRAQAAHQMATCALQNILAQMNGKPLKSYRYK
CHHCCCCCCEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
DHGSLVSLSNFSTVGSLMGNLTKGSMMIEGRIARFVYISLYRMHQIALHGYFKTGLMMLV
CCCCEEEECCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSINRVIRPRLKLH
HHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]