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The map label for this gene is yeaP [H]

Identifier: 218549161

GI number: 218549161

Start: 1870514

End: 1871554

Strand: Direct

Name: yeaP [H]

Synonym: EFER_1815

Alternate gene names: 218549161

Gene position: 1870514-1871554 (Clockwise)

Preceding gene: 218549159

Following gene: 218549186

Centisome position: 40.76

GC content: 45.44

Gene sequence:

>1041_bases
GTGTCGGATAAAATCCTCGCTCGTGTATCGCAATCATTAGCCTCAGAACAATCACTTGAAAGCCTAGTCCGCCAGCTTCT
TGAGATGCTTGAAATGGTTACCGATATGGAGTCAACGTATCTGACAAAAGTCGATGTTGATGCCCGCTTGCAGCATATTC
TGTTTGCCCATAATAGCCAGCAGATGTGTATCCCGGAGGATTACTCTGTAATGTGGGATAACTCACTGTGTAAACGTGCG
ATTGATGAGAACTGCTTTTACAGCGATGAAGTTAATGTTCGCTGGAAGGATTGTATCGCCGCAACGACTTTGGGTATCAC
CACTTTTCTCAGCACGCCAATACATCTTCCAGATGGCTCTTTTTACGGTACTTTATGTGCCGCCAGTAGTGAGAAAAAGC
CCTGGAGTGAACGCGCTGAGCAGGTCTTACAATTGTTTGCCGGTTTAATCGCACAGTACATTCAGAAAGAATCGCTGGTC
ACGCAACTGCGTGAAGCTAATACCGCACTGGTTCAGCAATCCTGTACGGATGCACTAACGGGTTTACCCAATCGTCGGGC
GATTTTTGAGCATTTACCAACACTGTTTACACTGGCACAAAAACTTGGTCGCAACGTGTTGCTGGCTTACATCGATCTGG
ATAATTTCAAAAAAATAAATGATCGCTTTGGTCATAGTACAGGTGACCGATTTTTAATTGAGATCGGTGAACGTCTGAAG
GCGATTCCCGATAAATACGATATCCTCGGACGTCTTGGTGGCGATGAGTTTTTGCTCGCCTGCCTGGCTGAAATTAAAAA
TGATGACTCACTGAATCTACGTCAACAGATGAAAATGCGCATTCAGCAACAGATTCGCGGTGAGTACTATCTTCCCGATG
CCGCGTTTTATTATCCTGGCGCCAGTATGGGGGTGTTGGAAGTTGATCCATCCATAACAGATATAGATTCAGCACTGAAT
GCGGCTGATCGTGTTATGTATGAAGATAAAAAACAGCGGGCGAAAACTCCTTTTGTCGTTCACGAAGCCCTGCTATCCTG
A

Upstream 100 bases:

>100_bases
TATGAATATTTTGCCAGGTATTATATTTGTTGCTTATGTTTTATCATGTCAGCAAAGCTGAAATTTTCAGCACAATCTTT
GGCACCCTCTGGAGAGAATC

Downstream 100 bases:

>100_bases
CGCGTCCTCAGTATCTCTTCAGGTGGAACCATGAGAATTGGTATAATGTTCCCCGTTGTCATATTCATCACGGCTATTGT
ATTTCTGGCGTGGTTTTTTA

Product: hypothetical protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSDKILARVSQSLASEQSLESLVRQLLEMLEMVTDMESTYLTKVDVDARLQHILFAHNSQQMCIPEDYSVMWDNSLCKRA
IDENCFYSDEVNVRWKDCIAATTLGITTFLSTPIHLPDGSFYGTLCAASSEKKPWSERAEQVLQLFAGLIAQYIQKESLV
TQLREANTALVQQSCTDALTGLPNRRAIFEHLPTLFTLAQKLGRNVLLAYIDLDNFKKINDRFGHSTGDRFLIEIGERLK
AIPDKYDILGRLGGDEFLLACLAEIKNDDSLNLRQQMKMRIQQQIRGEYYLPDAAFYYPGASMGVLEVDPSITDIDSALN
AADRVMYEDKKQRAKTPFVVHEALLS

Sequences:

>Translated_346_residues
MSDKILARVSQSLASEQSLESLVRQLLEMLEMVTDMESTYLTKVDVDARLQHILFAHNSQQMCIPEDYSVMWDNSLCKRA
IDENCFYSDEVNVRWKDCIAATTLGITTFLSTPIHLPDGSFYGTLCAASSEKKPWSERAEQVLQLFAGLIAQYIQKESLV
TQLREANTALVQQSCTDALTGLPNRRAIFEHLPTLFTLAQKLGRNVLLAYIDLDNFKKINDRFGHSTGDRFLIEIGERLK
AIPDKYDILGRLGGDEFLLACLAEIKNDDSLNLRQQMKMRIQQQIRGEYYLPDAAFYYPGASMGVLEVDPSITDIDSALN
AADRVMYEDKKQRAKTPFVVHEALLS
>Mature_345_residues
SDKILARVSQSLASEQSLESLVRQLLEMLEMVTDMESTYLTKVDVDARLQHILFAHNSQQMCIPEDYSVMWDNSLCKRAI
DENCFYSDEVNVRWKDCIAATTLGITTFLSTPIHLPDGSFYGTLCAASSEKKPWSERAEQVLQLFAGLIAQYIQKESLVT
QLREANTALVQQSCTDALTGLPNRRAIFEHLPTLFTLAQKLGRNVLLAYIDLDNFKKINDRFGHSTGDRFLIEIGERLKA
IPDKYDILGRLGGDEFLLACLAEIKNDDSLNLRQQMKMRIQQQIRGEYYLPDAAFYYPGASMGVLEVDPSITDIDSALNA
ADRVMYEDKKQRAKTPFVVHEALLS

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=346, Percent_Identity=72.8323699421965, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1786584, Length=171, Percent_Identity=29.8245614035088, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788956, Length=175, Percent_Identity=33.1428571428571, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787541, Length=172, Percent_Identity=30.2325581395349, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788381, Length=172, Percent_Identity=29.0697674418605, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082007, Length=184, Percent_Identity=28.804347826087, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI145693134, Length=130, Percent_Identity=32.3076923076923, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87081881, Length=179, Percent_Identity=30.1675977653631, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787816, Length=171, Percent_Identity=29.8245614035088, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081974, Length=165, Percent_Identity=30.9090909090909, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 39152; Mature: 39021

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKILARVSQSLASEQSLESLVRQLLEMLEMVTDMESTYLTKVDVDARLQHILFAHNSQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHCCCC
QMCIPEDYSVMWDNSLCKRAIDENCFYSDEVNVRWKDCIAATTLGITTFLSTPIHLPDGS
CCCCCCCCCEEECHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
FYGTLCAASSEKKPWSERAEQVLQLFAGLIAQYIQKESLVTQLREANTALVQQSCTDALT
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLPNRRAIFEHLPTLFTLAQKLGRNVLLAYIDLDNFKKINDRFGHSTGDRFLIEIGERLK
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHH
AIPDKYDILGRLGGDEFLLACLAEIKNDDSLNLRQQMKMRIQQQIRGEYYLPDAAFYYPG
HCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEECCC
ASMGVLEVDPSITDIDSALNAADRVMYEDKKQRAKTPFVVHEALLS
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
>Mature Secondary Structure 
SDKILARVSQSLASEQSLESLVRQLLEMLEMVTDMESTYLTKVDVDARLQHILFAHNSQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHCCCC
QMCIPEDYSVMWDNSLCKRAIDENCFYSDEVNVRWKDCIAATTLGITTFLSTPIHLPDGS
CCCCCCCCCEEECHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
FYGTLCAASSEKKPWSERAEQVLQLFAGLIAQYIQKESLVTQLREANTALVQQSCTDALT
CHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLPNRRAIFEHLPTLFTLAQKLGRNVLLAYIDLDNFKKINDRFGHSTGDRFLIEIGERLK
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHH
AIPDKYDILGRLGGDEFLLACLAEIKNDDSLNLRQQMKMRIQQQIRGEYYLPDAAFYYPG
HCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEECCCCCEECCC
ASMGVLEVDPSITDIDSALNAADRVMYEDKKQRAKTPFVVHEALLS
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]