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The map label for this gene is yeaE [H]

Identifier: 218549150

GI number: 218549150

Start: 1858282

End: 1859181

Strand: Reverse

Name: yeaE [H]

Synonym: EFER_1803

Alternate gene names: 218549150

Gene position: 1859181-1858282 (Counterclockwise)

Preceding gene: 218549151

Following gene: 218549141

Centisome position: 40.52

GC content: 49.33

Gene sequence:

>900_bases
ATGCCCTGTTTTGCATTACGGTGGTGCATAAACAAGGAGGATGTGATGCAAAAGAAATCGATTCTTTTTAGTGGTGGAGC
ATCTTTGCCAGCAATGGGTCAGGGAACCTGGTATATGGGCGAGGATGCAGGCAAGCGCAAAGAGGAAGTCGCTGCACTGC
GTGCGGGCATTGAGCTGGGGTTAACGCTGATTGATACCGCAGAAATGTATGCTGACGGCGGTGCCGAAAAGGTGGTTGGC
GAAGCGCTGACGGGTCTGCGTGATAACGTATTCCTCGTTTCTAAAGTTTATCCGTGGAATGCGGGTGGCAAAAAAGCCAT
TGCAGCTTGTGAAAATAGTCTGCATCGTCTGAATACCGAATATCTTGATCTTTATTTGCTGCACTGGTCAGGCAGTTTCA
CATTTGAAGAAACTGTGGATGCAATGGAAACGCTTATCGCGCAAGGGAAAATCTGTCGTTGGGGTGTTTCTAATCTCGAT
TATGCTGATATGCAGGCGTTGTGGCAGACCACAGGGGGTAAGCAATGCGCCACTAACCAGGTGCTTTATCATCTCGGTTC
ACGCGGGATCGAATATGATCTCCTTCCATGGTGCCAGCAGCAACATATGCCAGTAATGGCGTACAGTCCATTAGCACAAG
CCGGACGGCTACGAAATGGCTTGTTTAATCACCCCGTGGTTATTGATATTGCCCACAGGCATAGCGCCACGGCGGCGCAA
ATTTTACTGGCATGGGTGATCAGCCACCAGGGCGTGATGGCTATTCCGAAAGCGGCAACGGTAGACCACGTTAAACAGAA
TGCTGCGGCACTGGATTTGACACTTTCCAGTGAAGAATTAACGTTATTAGATAAAGCTTTTCCAGCACCGCAAGGCAAAA
CGGCACTGGATATGGTGTGA

Upstream 100 bases:

>100_bases
TGGTGGATAAATCCTGGACTGGTCTGATTTCTGCCGGGATCACGTACAAATTCTGATTGTGCTCCTCCAAAGCGCATTTT
ATGCATAAAAACAGGGCGTC

Downstream 100 bases:

>100_bases
CTGGAGATAAGATATGCCTGAGCCCAGTAAAGATGCTCAGGCATTTTTTTACCCTTCGAAGAACCAGTAACCGCTATTTA
CCAGTGCTGCCAGCATAGCA

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MPCFALRWCINKEDVMQKKSILFSGGASLPAMGQGTWYMGEDAGKRKEEVAALRAGIELGLTLIDTAEMYADGGAEKVVG
EALTGLRDNVFLVSKVYPWNAGGKKAIAACENSLHRLNTEYLDLYLLHWSGSFTFEETVDAMETLIAQGKICRWGVSNLD
YADMQALWQTTGGKQCATNQVLYHLGSRGIEYDLLPWCQQQHMPVMAYSPLAQAGRLRNGLFNHPVVIDIAHRHSATAAQ
ILLAWVISHQGVMAIPKAATVDHVKQNAAALDLTLSSEELTLLDKAFPAPQGKTALDMV

Sequences:

>Translated_299_residues
MPCFALRWCINKEDVMQKKSILFSGGASLPAMGQGTWYMGEDAGKRKEEVAALRAGIELGLTLIDTAEMYADGGAEKVVG
EALTGLRDNVFLVSKVYPWNAGGKKAIAACENSLHRLNTEYLDLYLLHWSGSFTFEETVDAMETLIAQGKICRWGVSNLD
YADMQALWQTTGGKQCATNQVLYHLGSRGIEYDLLPWCQQQHMPVMAYSPLAQAGRLRNGLFNHPVVIDIAHRHSATAAQ
ILLAWVISHQGVMAIPKAATVDHVKQNAAALDLTLSSEELTLLDKAFPAPQGKTALDMV
>Mature_298_residues
PCFALRWCINKEDVMQKKSILFSGGASLPAMGQGTWYMGEDAGKRKEEVAALRAGIELGLTLIDTAEMYADGGAEKVVGE
ALTGLRDNVFLVSKVYPWNAGGKKAIAACENSLHRLNTEYLDLYLLHWSGSFTFEETVDAMETLIAQGKICRWGVSNLDY
ADMQALWQTTGGKQCATNQVLYHLGSRGIEYDLLPWCQQQHMPVMAYSPLAQAGRLRNGLFNHPVVIDIAHRHSATAAQI
LLAWVISHQGVMAIPKAATVDHVKQNAAALDLTLSSEELTLLDKAFPAPQGKTALDMV

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=296, Percent_Identity=30.7432432432432, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI24497577, Length=312, Percent_Identity=28.525641025641, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI5174391, Length=312, Percent_Identity=28.525641025641, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI291291012, Length=273, Percent_Identity=30.7692307692308, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI93277124, Length=301, Percent_Identity=26.9102990033223, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4502049, Length=298, Percent_Identity=28.8590604026846, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI5174695, Length=297, Percent_Identity=26.9360269360269, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI310109922, Length=283, Percent_Identity=27.9151943462898, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI45446745, Length=306, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI4503285, Length=306, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI310109920, Length=304, Percent_Identity=26.6447368421053, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI300116273, Length=284, Percent_Identity=26.7605633802817, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=27.1739130434783, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI5453543, Length=306, Percent_Identity=26.1437908496732, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI223718702, Length=198, Percent_Identity=31.3131313131313, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788081, Length=284, Percent_Identity=83.0985915492958, Blast_Score=489, Evalue=1e-140,
Organism=Escherichia coli, GI87082198, Length=265, Percent_Identity=30.188679245283, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786400, Length=260, Percent_Identity=28.8461538461538, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87081735, Length=300, Percent_Identity=28, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788070, Length=322, Percent_Identity=27.9503105590062, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1789199, Length=338, Percent_Identity=28.698224852071, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789375, Length=313, Percent_Identity=24.6006389776358, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI48994888, Length=293, Percent_Identity=25.5972696245734, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17564128, Length=307, Percent_Identity=30.9446254071661, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17552492, Length=275, Percent_Identity=29.8181818181818, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17561298, Length=286, Percent_Identity=29.7202797202797, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17537077, Length=299, Percent_Identity=29.4314381270903, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17537075, Length=299, Percent_Identity=29.4314381270903, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71998625, Length=290, Percent_Identity=28.9655172413793, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17566692, Length=304, Percent_Identity=27.6315789473684, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17561300, Length=266, Percent_Identity=27.8195488721804, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17538386, Length=280, Percent_Identity=27.8571428571429, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=301, Percent_Identity=24.5847176079734, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322556, Length=285, Percent_Identity=26.6666666666667, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320079, Length=273, Percent_Identity=27.8388278388278, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323998, Length=317, Percent_Identity=25.8675078864353, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319958, Length=288, Percent_Identity=25, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644950, Length=309, Percent_Identity=31.3915857605178, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI221378297, Length=329, Percent_Identity=28.8753799392097, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45553081, Length=291, Percent_Identity=26.8041237113402, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24662789, Length=311, Percent_Identity=27.6527331189711, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24663317, Length=296, Percent_Identity=24.3243243243243, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24657054, Length=290, Percent_Identity=25.1724137931034, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21356425, Length=292, Percent_Identity=23.972602739726, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24662781, Length=296, Percent_Identity=26.6891891891892, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129731, Length=292, Percent_Identity=24.3150684931507, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24662785, Length=304, Percent_Identity=25.6578947368421, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 32723; Mature: 32592

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPCFALRWCINKEDVMQKKSILFSGGASLPAMGQGTWYMGEDAGKRKEEVAALRAGIELG
CCCEEEEECCCHHHHHHHHHHEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHC
LTLIDTAEMYADGGAEKVVGEALTGLRDNVFLVSKVYPWNAGGKKAIAACENSLHRLNTE
EEEEEHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
YLDLYLLHWSGSFTFEETVDAMETLIAQGKICRWGVSNLDYADMQALWQTTGGKQCATNQ
CEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHH
VLYHLGSRGIEYDLLPWCQQQHMPVMAYSPLAQAGRLRNGLFNHPVVIDIAHRHSATAAQ
HHHHHCCCCCCCCCCCHHHHCCCCEEEECCHHHHHHHHCCCCCCCEEEEECCCCCHHHHH
ILLAWVISHQGVMAIPKAATVDHVKQNAAALDLTLSSEELTLLDKAFPAPQGKTALDMV
HHHHHHHHCCCEEECCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PCFALRWCINKEDVMQKKSILFSGGASLPAMGQGTWYMGEDAGKRKEEVAALRAGIELG
CCEEEEECCCHHHHHHHHHHEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHC
LTLIDTAEMYADGGAEKVVGEALTGLRDNVFLVSKVYPWNAGGKKAIAACENSLHRLNTE
EEEEEHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCC
YLDLYLLHWSGSFTFEETVDAMETLIAQGKICRWGVSNLDYADMQALWQTTGGKQCATNQ
CEEEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHH
VLYHLGSRGIEYDLLPWCQQQHMPVMAYSPLAQAGRLRNGLFNHPVVIDIAHRHSATAAQ
HHHHHCCCCCCCCCCCHHHHCCCCEEEECCHHHHHHHHCCCCCCCEEEEECCCCCHHHHH
ILLAWVISHQGVMAIPKAATVDHVKQNAAALDLTLSSEELTLLDKAFPAPQGKTALDMV
HHHHHHHHCCCEEECCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]