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The map label for this gene is cvrA [H]

Identifier: 218549112

GI number: 218549112

Start: 1813286

End: 1815019

Strand: Direct

Name: cvrA [H]

Synonym: EFER_1764

Alternate gene names: 218549112

Gene position: 1813286-1815019 (Clockwise)

Preceding gene: 218549111

Following gene: 218549115

Centisome position: 39.52

GC content: 50.58

Gene sequence:

>1734_bases
TTGGATGCCACGACGATCATCAGTCTGTTTATTTTAGGGTCAGTGCTTGTTACCTGCAGTATTCTCCTCAGTTCGTTTTC
TTCACGTCTTGGCATTCCTATTCTGGTTATCTTTTTGGCGATCGGTATGCTCGCCGGGGTCGATGGTGTCGGCGGTATTC
CATTCGATAATTATCCCTTCGCTTATATGGTCAGCAACCTCGCACTGGCGGTCATTTTACTTGATGGCGGAATGCGTACC
CAGGCCAGCTCGTTTCGTGTTGCTCTCGGCCCGGCACTCTCCCTCGCGACCGTGGGTGTGCTGATCACCTCAGGCCTGAC
GGGCATGATGGCAGCCTGGTTATTTAATCTCGATTTGATCGAAGGATTATTAATTGGCGCAATTGTCGGTTCTACCGATG
CTGCGGCAGTGTTTTCGCTGCTTGGTGGTAAAGGGCTTAACGAACGTGTTGGATCTACACTGGAAATAGAATCTGGCAGT
AATGATCCGATGGCGGTGTTTTTAACCATTACGCTGATTGAAATGATCCAGCATCACGAAACAGGAGTCAGCTGGACCTT
TGCATTGGATATTCTGCAACAGTTCGGCCTGGGTATCCTGTTGGGTCTGGGAGGTGGCTATTTACTTCAGCAGATGATTA
ACCGTATCGCCCTGCCTGCCGGGCTTTATCCAATGCTGGCATTAAGCGGCGGTATCCTGATTTTTGCGCTGACTACAGCA
CTTGAAGGCAGTGGCATTCTGGCAGTTTATCTATGTGGTTTCCTGCTCGGCAACCGACCGATTCGCAACCGCTACGGGAT
ATTGCAAAACTTCGACGGTCTGGCGTGGCTGGCGCAAATCGCCATGTTCCTGGTGCTCGGTTTACTGGTTAATCCTTCTG
ATCTGCTACCGATTGCTATTCCAGCACTACTTCTTTCCGCGTGGATGATTTTCTTTGCCCGTCCACTGTCAGTCTTTGCC
GGACTTCTGCCTTTCCGCGGTTTTAATCTACGGGAACGTATTTTTATCAGTTGGGTCGGCTTACGCGGAGCTGTACCTAT
TATTCTTGCGGTCTTTCCGATGATGGCCGGCCTGGATAATTCTCGTCTGTTCTTTAATGTGGCCTTCTTTGTGGTCTTAA
TTTCACTGTTGTTTCAGGGAACGTCTCTCTCCTGGGCAGCAAAAAAAGCGAAAGTCGTGGTGCCTGCCGTTGGTTGGCCC
GTCTCCCGCGTTGGTCTGGATATTCACCCGGAAAACCCGTGGGAACAGTTTGTTTATCAATTGAGTGCCGATAAATGGTG
TGTCGGTGCAGCATTACGCGATCTGCATATGCCCAAAGACACACGAATAGCGGCACTGTTTCGCGACAACGTGCTGTTGC
ATCCCTCGGGCAGTACCCGCCTGCGTGAAGGTGATGTACTTTGTGTGATTGGTCGTGAACGCGATCTTCCGGCGCTGGGC
AAATTATTTAGTCAATCACCGCCTGTGGCCCTGGATCAGCGTTTCTTTGGTGATTTTATTCTTGAAGGGAGCGCCAAATT
TGCTGATGTGGCGATTATTTATGGCCTCGATGCGGGCACTGAATATCGTGATAAACAACAGACGCTGGGCGAGATTGTAC
AGCAACTACTCGGGGCCGCCCCGGTTGTGGGTGACCAGGTAGAATTCGCGGGGATGATTTGGACGGTTGCTGAAAAAGAG
GATAATCAGGTCATGAAAGTGGGCGTTCGTGTCGCCGATGAGATTGCCGAATAA

Upstream 100 bases:

>100_bases
TTAAAAAAAACGTGAATAAGCGTTAACTATCCCGCTGTTTCGGTCGTTAATATGGTAGTGTTGTTACTACGAAACAGCGT
AATTTGGGAGAAACATAACG

Downstream 100 bases:

>100_bases
ACTCATCATTACCGGAGAGAGACGACTGTCTTCTCCGGTATGAATGCGTTACACTGTCACTACTGGCACACGCAGTGCCA
GAGCACACATCAACTCATAG

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MDATTIISLFILGSVLVTCSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAVILLDGGMRT
QASSFRVALGPALSLATVGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIEMIQHHETGVSWTFALDILQQFGLGILLGLGGGYLLQQMINRIALPAGLYPMLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALLLSAWMIFFARPLSVFA
GLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLDNSRLFFNVAFFVVLISLLFQGTSLSWAAKKAKVVVPAVGWP
VSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKDTRIAALFRDNVLLHPSGSTRLREGDVLCVIGRERDLPALG
KLFSQSPPVALDQRFFGDFILEGSAKFADVAIIYGLDAGTEYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKE
DNQVMKVGVRVADEIAE

Sequences:

>Translated_577_residues
MDATTIISLFILGSVLVTCSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAVILLDGGMRT
QASSFRVALGPALSLATVGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIEMIQHHETGVSWTFALDILQQFGLGILLGLGGGYLLQQMINRIALPAGLYPMLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALLLSAWMIFFARPLSVFA
GLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLDNSRLFFNVAFFVVLISLLFQGTSLSWAAKKAKVVVPAVGWP
VSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKDTRIAALFRDNVLLHPSGSTRLREGDVLCVIGRERDLPALG
KLFSQSPPVALDQRFFGDFILEGSAKFADVAIIYGLDAGTEYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKE
DNQVMKVGVRVADEIAE
>Mature_577_residues
MDATTIISLFILGSVLVTCSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAVILLDGGMRT
QASSFRVALGPALSLATVGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIEMIQHHETGVSWTFALDILQQFGLGILLGLGGGYLLQQMINRIALPAGLYPMLALSGGILIFALTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALLLSAWMIFFARPLSVFA
GLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLDNSRLFFNVAFFVVLISLLFQGTSLSWAAKKAKVVVPAVGWP
VSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKDTRIAALFRDNVLLHPSGSTRLREGDVLCVIGRERDLPALG
KLFSQSPPVALDQRFFGDFILEGSAKFADVAIIYGLDAGTEYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKE
DNQVMKVGVRVADEIAE

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=577, Percent_Identity=93.4142114384749, Blast_Score=1010, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 61988; Mature: 61988

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDATTIISLFILGSVLVTCSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
AYMVSNLALAVILLDGGMRTQASSFRVALGPALSLATVGVLITSGLTGMMAAWLFNLDLI
HHHHHHHHEEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIEMIQHHE
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCEEEECCCCCCCEEHHHHHHHHHHHHHHC
TGVSWTFALDILQQFGLGILLGLGGGYLLQQMINRIALPAGLYPMLALSGGILIFALTTA
CCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEEEHHH
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAI
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
PALLLSAWMIFFARPLSVFAGLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLDN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCC
SRLFFNVAFFVVLISLLFQGTSLSWAAKKAKVVVPAVGWPVSRVGLDIHPENPWEQFVYQ
CHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCCHHHCCEECCCCCHHHHHHHH
LSADKWCVGAALRDLHMPKDTRIAALFRDNVLLHPSGSTRLREGDVLCVIGRERDLPALG
HCCCCHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCEEECCCEEEEECCCCCCHHHH
KLFSQSPPVALDQRFFGDFILEGSAKFADVAIIYGLDAGTEYRDKQQTLGEIVQQLLGAA
HHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
PVVGDQVEFAGMIWTVAEKEDNQVMKVGVRVADEIAE
CCCCCCCHHCEEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDATTIISLFILGSVLVTCSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
AYMVSNLALAVILLDGGMRTQASSFRVALGPALSLATVGVLITSGLTGMMAAWLFNLDLI
HHHHHHHHEEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
EGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGSNDPMAVFLTITLIEMIQHHE
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHCCCEEEECCCCCCCEEHHHHHHHHHHHHHHC
TGVSWTFALDILQQFGLGILLGLGGGYLLQQMINRIALPAGLYPMLALSGGILIFALTTA
CCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHCCCEEEEEEHHH
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAI
CCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
PALLLSAWMIFFARPLSVFAGLLPFRGFNLRERIFISWVGLRGAVPIILAVFPMMAGLDN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCC
SRLFFNVAFFVVLISLLFQGTSLSWAAKKAKVVVPAVGWPVSRVGLDIHPENPWEQFVYQ
CHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEECCCCHHHCCEECCCCCHHHHHHHH
LSADKWCVGAALRDLHMPKDTRIAALFRDNVLLHPSGSTRLREGDVLCVIGRERDLPALG
HCCCCHHHHHHHHHHCCCCCCEEEEEEECCEEECCCCCCEEECCCEEEEECCCCCCHHHH
KLFSQSPPVALDQRFFGDFILEGSAKFADVAIIYGLDAGTEYRDKQQTLGEIVQQLLGAA
HHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCC
PVVGDQVEFAGMIWTVAEKEDNQVMKVGVRVADEIAE
CCCCCCCHHCEEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA