BacMap

Definition	Escherichia fergusonii ATCC 35469 chromosome, complete genome.
Accession	NC_011740
Length	4,588,711

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The map label for this gene is yciK [H]

Identifier: 218549038

GI number: 218549038

Start: 1733436

End: 1734194

Strand: Direct

Name: yciK [H]

Synonym: EFER_1686

Alternate gene names: 218549038

Gene position: 1733436-1734194 (Clockwise)

Preceding gene: 218549036

Following gene: 218549039

Centisome position: 37.78

GC content: 51.12

Gene sequence:

>759_bases
ATGCATTACCAACCCAAACAAGATTTATTGCACGATCGTATTATTCTGGTCACCGGAGCAAGTGACGGTATTGGTCGTGA
AGCAGCGCTAACATACGCGCGCTATGGTGCAACGGTTATTTTACTGGGAAGAAACGAAGATAAATTACGCCAGGTGGCAA
AAGCCATAACCGAAGAAACAGATCGCAAGACCCAATGGTATATCCTCGACTTACTTACCTGTTCATCTGAGGATTGTTAT
CATCTGGCCGCCCAAATTTCTGAAAATTATCCACGACTGGACGGCGTGCTGCATAACGCCGGGTTGCTCGGCGATGTTTG
CCCAATGAGCGAACAAAATCCGCAGGTCTGGCAGGACGTCATGCAGGTCAACGTTAATGCCACCTTTATGCTCACCCAGG
CACTGCTTCCTTTATTACTCAAATCGGACGCTGGTTCACTGGTCTTTACTTCATCAAGCGTTGGACGTCAGGGGCGTGCA
AACTGGGGCGCATATGCAGCATCGAAATTTGCCACCGAAGGGATGATGCAGGTACTGGCCGATGAATATCAGCAACGTCT
GCGCGTTAACTGTATTAACCCAGGCGGTACGCGCACCGCAATGCGGGCCAGCGCCTTCCCGACCGAAGATCCACAGAAAC
TTAAAACACCCGCTGATATCATGCCGCTCTACCTCTGGCTGATGGGCGATGACAGCCGCCGTAAAACCGGCATGACCTTT
GACGCCCAACCGGGCCGTAAACCAGGAATATCCCAATGA

Upstream 100 bases:

>100_bases
TCCGCTGATTGAAAAAATAGAGGGTTTCAGGCATAACACCACAAAGTCGTAACAAAAAGCCAACTGGCAAAACGATCCGC
TGGACCGTTAGGGAGTCGTG

Downstream 100 bases:

>100_bases
GTGATGAACGCTACCAACAGCGTCAGCAGCGTGTAAAAGATAAAGTGGATGCCCGTGTGGCCCAGGCCCAGGATGAACGC
GGTATTATCATCGTCTTTAC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MHYQPKQDLLHDRIILVTGASDGIGREAALTYARYGATVILLGRNEDKLRQVAKAITEETDRKTQWYILDLLTCSSEDCY
HLAAQISENYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

Sequences:

>Translated_252_residues
MHYQPKQDLLHDRIILVTGASDGIGREAALTYARYGATVILLGRNEDKLRQVAKAITEETDRKTQWYILDLLTCSSEDCY
HLAAQISENYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ
>Mature_252_residues
MHYQPKQDLLHDRIILVTGASDGIGREAALTYARYGATVILLGRNEDKLRQVAKAITEETDRKTQWYILDLLTCSSEDCY
HLAAQISENYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI20149619, Length=204, Percent_Identity=30.3921568627451, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI142976729, Length=211, Percent_Identity=28.9099526066351, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4504505, Length=233, Percent_Identity=28.755364806867, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40807363, Length=207, Percent_Identity=28.0193236714976, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=26.9076305220884, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI66933014, Length=246, Percent_Identity=29.6747967479675, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI10190704, Length=189, Percent_Identity=24.3386243386243, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI33667109, Length=202, Percent_Identity=29.7029702970297, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI210032110, Length=186, Percent_Identity=26.8817204301075, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7705855, Length=206, Percent_Identity=27.6699029126214, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI5031737, Length=198, Percent_Identity=29.2929292929293, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310128830, Length=185, Percent_Identity=28.1081081081081, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI310115468, Length=185, Percent_Identity=28.1081081081081, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI7657478, Length=222, Percent_Identity=29.7297297297297, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4503817, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI15277342, Length=261, Percent_Identity=27.5862068965517, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI59889578, Length=171, Percent_Identity=30.9941520467836, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI157739938, Length=193, Percent_Identity=25.9067357512953, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI126723191, Length=199, Percent_Identity=27.1356783919598, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=92.8571428571429, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=27.7551020408163, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789378, Length=240, Percent_Identity=32.5, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=30.5555555555556, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=27.4193548387097, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786701, Length=206, Percent_Identity=29.126213592233, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790717, Length=191, Percent_Identity=28.7958115183246, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787820, Length=224, Percent_Identity=23.2142857142857, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=221, Percent_Identity=30.316742081448, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=206, Percent_Identity=30.5825242718447, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=30.6451612903226, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=189, Percent_Identity=31.7460317460317, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=200, Percent_Identity=31, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=28.1124497991968, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=231, Percent_Identity=29.004329004329, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71997402, Length=253, Percent_Identity=28.0632411067194, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17570069, Length=203, Percent_Identity=28.0788177339901, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560176, Length=179, Percent_Identity=29.608938547486, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=199, Percent_Identity=32.1608040201005, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=182, Percent_Identity=29.1208791208791, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=210, Percent_Identity=27.1428571428571, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=186, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=242, Percent_Identity=26.8595041322314, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=200, Percent_Identity=28, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=197, Percent_Identity=30.4568527918782, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=24.8062015503876, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=213, Percent_Identity=25.3521126760563, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=239, Percent_Identity=24.6861924686192, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=201, Percent_Identity=26.3681592039801, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=203, Percent_Identity=25.615763546798, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=212, Percent_Identity=25.4716981132075, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=209, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=207, Percent_Identity=26.5700483091787, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=207, Percent_Identity=26.5700483091787, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=214, Percent_Identity=26.1682242990654, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25152911, Length=203, Percent_Identity=27.0935960591133, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=26.6932270916335, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI212646214, Length=191, Percent_Identity=25.130890052356, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=205, Percent_Identity=25.3658536585366, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=214, Percent_Identity=30.3738317757009, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=226, Percent_Identity=28.7610619469027, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322861, Length=233, Percent_Identity=26.1802575107296, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322226, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=27.3092369477912, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640492, Length=182, Percent_Identity=30.2197802197802, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=33.1550802139037, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=27.5303643724696, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=187, Percent_Identity=29.9465240641711, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI161076933, Length=190, Percent_Identity=28.9473684210526, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24584748, Length=190, Percent_Identity=28.9473684210526, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24643142, Length=205, Percent_Identity=33.1707317073171, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281364892, Length=204, Percent_Identity=29.9019607843137, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21358495, Length=207, Percent_Identity=28.9855072463768, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=27.6679841897233, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581726, Length=211, Percent_Identity=26.5402843601896, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=28.7878787878788, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45553409, Length=217, Percent_Identity=27.6497695852535, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24647948, Length=217, Percent_Identity=27.6497695852535, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24647946, Length=217, Percent_Identity=27.6497695852535, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18859837, Length=223, Percent_Identity=28.6995515695067, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356301, Length=206, Percent_Identity=27.1844660194175, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24584752, Length=230, Percent_Identity=29.1304347826087, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27956; Mature: 27956

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYQPKQDLLHDRIILVTGASDGIGREAALTYARYGATVILLGRNEDKLRQVAKAITEET
CCCCCHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHC
DRKTQWYILDLLTCSSEDCYHLAAQISENYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDV
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
MQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
HHHHHHHEEEEECCCCCCHHHCCCCCCCCCHHHHCCCHHHHEEEEEEECCCCCCCCCCEE
DAQPGRKPGISQ
CCCCCCCCCCCC
>Mature Secondary Structure
MHYQPKQDLLHDRIILVTGASDGIGREAALTYARYGATVILLGRNEDKLRQVAKAITEET
CCCCCHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHC
DRKTQWYILDLLTCSSEDCYHLAAQISENYPRLDGVLHNAGLLGDVCPMSEQNPQVWQDV
CCCCEEEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
MQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
HHHHHHHEEEEECCCCCCHHHCCCCCCCCCHHHHCCCHHHHEEEEEEECCCCCCCCCCEE
DAQPGRKPGISQ
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]