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The map label for this gene is add [H]

Identifier: 218548781

GI number: 218548781

Start: 1458674

End: 1459780

Strand: Reverse

Name: add [H]

Synonym: EFER_1420

Alternate gene names: 218548781

Gene position: 1459780-1458674 (Counterclockwise)

Preceding gene: 218548782

Following gene: 218548779

Centisome position: 31.81

GC content: 48.87

Gene sequence:

>1107_bases
ATGTGTTGCGCAATAGATATATTTATTGCGCAACGTAGATTTTTCCGAAGATTTGTTTTTATAATGGCGCGCACTTTTAT
ATTCAAAATAATGAGTGCAATTATGATTGATACTTCTCTGCCATTAACTGATATCCATCGCCACCTCGACGGTAACATTC
GCCCACAAACCATTCTTGAACTTGGTCGTCAACACAATATTGTGCTGCCTGCTGATTCTCTTGAGGCGCTTATCCCCCAT
GTCCAGGTCACCAGCACTGAACCGGATCTGGTGAGCTTTTTAAGCAAGCTGGATTGGGGGGTAAAAGTCCTGGCATCGCT
GGATTCTGTTCGCCGCGTTGCTTTTGAGAATATTGAAGATGCTGCCCGTAATGGTCTGCATTATGTAGAGCTGCGTTTTT
CCCCTGGCTATATGGCTATGACTCACCAGTTGCCCGTTGCCGGGGTGGTGGAAGCGGTCATTGCTGGTGTTCAGGAAGGG
TGTAAAACTTTTGGTGTCGAAGCTCGCCTGATTGGCATAATGAGCCGTACTTTTGGTGAAGCTGCTTGTCTGCAGGAACT
TGAAGCGCTTTTAGCCCATCGGGATCACATTACTGCGCTGGATTTAGCCGGTGACGAACTTGGCTTCCCTGGTAGTCTGT
TCCTCTCTCATTTTAACCGTGCCCGCGACGCTGGCTGGCGTATTACTGTTCATGCTGGTGAAGCTGCTGGAGCCGAAAGT
ATTTGGCAGGCGATCCGTGAACTGGGTGCCGAACGTATTGGTCACGGCGTTAAAGCCATTGAGGATCGGGCGCTGATGGA
TTTTCTGGCGGAACAGCGGATCGGAATTGAGTCCTGTCTGACATCAAATATTCAGACCAGCACCGTCTCTTCTCTGAGTG
TGCATCCTCTTAAAACTTTTCTTGAACACGGTATTCTTGCCAGCCTGAATACGGATGATCCCGGCGTTCAGGGGGTTGAT
ATTATTCATGAATATAATATAGCAGCGCCTGCAGCCGGGTTATCCCGCGAGCAGATTCGCCAGGCGCAAATAAACGGTCT
GGAAATCGCTTTCCTGAGCGATGCAGAGAAAAAAGCCCTGCGTGCGAAAGTCGCTGCAGGACAATAA

Upstream 100 bases:

>100_bases
AGGACGCGGCTTTATCCGCCTTAATGTTGGATGCCCGCGCGCTAAACTGGAAAAAGGGGTGCAGGGATTAATTAAGGCAA
TATTGTCACTGCGGTGATTA

Downstream 100 bases:

>100_bases
CCACATGTTACAGACCGGCTTTGTTGCCGGTCTGTTCGTTTAAGATTATGCCAGAGAAAGTGTCGCCCGATGCTTCGCTG
ATTCAATGCCCAGCTCGATC

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MCCAIDIFIAQRRFFRRFVFIMARTFIFKIMSAIMIDTSLPLTDIHRHLDGNIRPQTILELGRQHNIVLPADSLEALIPH
VQVTSTEPDLVSFLSKLDWGVKVLASLDSVRRVAFENIEDAARNGLHYVELRFSPGYMAMTHQLPVAGVVEAVIAGVQEG
CKTFGVEARLIGIMSRTFGEAACLQELEALLAHRDHITALDLAGDELGFPGSLFLSHFNRARDAGWRITVHAGEAAGAES
IWQAIRELGAERIGHGVKAIEDRALMDFLAEQRIGIESCLTSNIQTSTVSSLSVHPLKTFLEHGILASLNTDDPGVQGVD
IIHEYNIAAPAAGLSREQIRQAQINGLEIAFLSDAEKKALRAKVAAGQ

Sequences:

>Translated_368_residues
MCCAIDIFIAQRRFFRRFVFIMARTFIFKIMSAIMIDTSLPLTDIHRHLDGNIRPQTILELGRQHNIVLPADSLEALIPH
VQVTSTEPDLVSFLSKLDWGVKVLASLDSVRRVAFENIEDAARNGLHYVELRFSPGYMAMTHQLPVAGVVEAVIAGVQEG
CKTFGVEARLIGIMSRTFGEAACLQELEALLAHRDHITALDLAGDELGFPGSLFLSHFNRARDAGWRITVHAGEAAGAES
IWQAIRELGAERIGHGVKAIEDRALMDFLAEQRIGIESCLTSNIQTSTVSSLSVHPLKTFLEHGILASLNTDDPGVQGVD
IIHEYNIAAPAAGLSREQIRQAQINGLEIAFLSDAEKKALRAKVAAGQ
>Mature_368_residues
MCCAIDIFIAQRRFFRRFVFIMARTFIFKIMSAIMIDTSLPLTDIHRHLDGNIRPQTILELGRQHNIVLPADSLEALIPH
VQVTSTEPDLVSFLSKLDWGVKVLASLDSVRRVAFENIEDAARNGLHYVELRFSPGYMAMTHQLPVAGVVEAVIAGVQEG
CKTFGVEARLIGIMSRTFGEAACLQELEALLAHRDHITALDLAGDELGFPGSLFLSHFNRARDAGWRITVHAGEAAGAES
IWQAIRELGAERIGHGVKAIEDRALMDFLAEQRIGIESCLTSNIQTSTVSSLSVHPLKTFLEHGILASLNTDDPGVQGVD
IIHEYNIAAPAAGLSREQIRQAQINGLEIAFLSDAEKKALRAKVAAGQ

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=339, Percent_Identity=32.7433628318584, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1787910, Length=332, Percent_Identity=88.855421686747, Blast_Score=607, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI32565969, Length=344, Percent_Identity=30.2325581395349, Blast_Score=124, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17538512, Length=344, Percent_Identity=30.2325581395349, Blast_Score=124, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324188, Length=344, Percent_Identity=26.453488372093, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24645260, Length=334, Percent_Identity=26.0479041916168, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006650
- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 40320; Mature: 40320

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00485 A_DEAMINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCCAIDIFIAQRRFFRRFVFIMARTFIFKIMSAIMIDTSLPLTDIHRHLDGNIRPQTILE
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHH
LGRQHNIVLPADSLEALIPHVQVTSTEPDLVSFLSKLDWGVKVLASLDSVRRVAFENIED
CCCCCCEEECCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARNGLHYVELRFSPGYMAMTHQLPVAGVVEAVIAGVQEGCKTFGVEARLIGIMSRTFGE
HHHCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AACLQELEALLAHRDHITALDLAGDELGFPGSLFLSHFNRARDAGWRITVHAGEAAGAES
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
IWQAIRELGAERIGHGVKAIEDRALMDFLAEQRIGIESCLTSNIQTSTVSSLSVHPLKTF
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHCCHHHHHHH
LEHGILASLNTDDPGVQGVDIIHEYNIAAPAAGLSREQIRQAQINGLEIAFLSDAEKKAL
HHCCCEEECCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHH
RAKVAAGQ
HHHHCCCC
>Mature Secondary Structure
MCCAIDIFIAQRRFFRRFVFIMARTFIFKIMSAIMIDTSLPLTDIHRHLDGNIRPQTILE
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHH
LGRQHNIVLPADSLEALIPHVQVTSTEPDLVSFLSKLDWGVKVLASLDSVRRVAFENIED
CCCCCCEEECCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARNGLHYVELRFSPGYMAMTHQLPVAGVVEAVIAGVQEGCKTFGVEARLIGIMSRTFGE
HHHCCCEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AACLQELEALLAHRDHITALDLAGDELGFPGSLFLSHFNRARDAGWRITVHAGEAAGAES
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHH
IWQAIRELGAERIGHGVKAIEDRALMDFLAEQRIGIESCLTSNIQTSTVSSLSVHPLKTF
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHCCHHHHHHH
LEHGILASLNTDDPGVQGVDIIHEYNIAAPAAGLSREQIRQAQINGLEIAFLSDAEKKAL
HHCCCEEECCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHCCCEEEEEECCHHHHHH
RAKVAAGQ
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA