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The map label for this gene is lolC [H]

Identifier: 218548646

GI number: 218548646

Start: 1319839

End: 1321038

Strand: Direct

Name: lolC [H]

Synonym: EFER_1280

Alternate gene names: 218548646

Gene position: 1319839-1321038 (Clockwise)

Preceding gene: 218548642

Following gene: 218548647

Centisome position: 28.76

GC content: 54.17

Gene sequence:

>1200_bases
ATGTACCAACCTGTCGCTCTATTTATTGGCCTGCGTTACATGCGTGGGCGTGCAGCGGATCGCTTCGGTCGTTTCGTCTC
CTGGCTTTCTACCATCGGCATTACCCTCGGGGTGATGGCACTGGTCACAGTATTGTCAGTGATGAACGGCTTTGAGCGCG
AGCTGCAAAACAACATCCTTGGCCTGATGCCACAGGCAATTCTCTCTTCTGAGCATGGCTCTCTTAACCCGCAGCAACTC
CCGGAAACGGCAGTCAAACTGGACGGCGTTAATCGCATCGCACCTGTCACTACCGGTGATGTGGTACTGCAAAGTGCACG
CAGCGTGGCGGTCGGGGTGATGCTGGGTATCGACCCGGCACAAAAAGATCCACTAACGCCGTATCTGGTCAATGTGAAAC
AAGCTGATCTCGAACCGGGGAAATATAATGTCATTCTCGGCGAACAACTTGCCTCACAGTTAGGTGTCAATCGCGGTGAT
CAAATCCGCGTGATGGTGCCGTCTGCCAGCCAGTTCACGCCGATGGGGCGTATTCCAAGCCAGCGCCTGTTCAATGTGAT
TGGCACTTTCGCCGCCAACAGTGAAGTCGATGGCTATGAAATGCTGGTGAATATTGAGGATGCCTCGCGTCTGATGCGTT
ATCCGGCAGGCAATATCACTGGCTGGCGTTTGTGGCTGGATGAGCCGCTGAAAGTTGATTCTTTAAGCCAGCAAAAACTG
CCTGAAGGCAGCAAATGGCAGGACTGGCGTGATCGTAAAGGCGAGCTGTTCCAGGCCGTACGCATGGAAAAAAATATGAT
GGGCTTACTGCTGAGCCTGATTGTCGCCGTTGCGGCGTTTAACATTATTACTTCGCTGGGGCTGATGGTGATGGAGAAGC
AGGGCGAAGTGGCGATCCTGCAAACGCAAGGCTTAACTCCGCGACAAATCATGATGGTCTTTATGGTGCAAGGGGCCAGC
GCCGGGATTATCGGTGCGATCCTCGGAGCGGCCCTTGGCGCACTGCTTGCCAGCCAGTTGAATAATCTGATGCCGATAAT
CGGCGTCCTGCTTGATGGCGCGGCACTGCCAGTCGCTATCGAACCTTTACAGGTCATTGTTATTGCGCTGGTGGCGATGG
CTATCGCGCTGCTCTCTACGCTTTACCCTTCATGGCGCGCTGCCGCCACTCAACCCGCTGAGGCTTTACGTTATGAATAA

Upstream 100 bases:

>100_bases
TTTCAGATTAGCCCTGACGATCACTTACAGTTCAGACGTTTACCCATCTTGCTTTCGCTTATATACTCGTGTCTTTGCTA
ACAGCAACCAGACGGATTTC

Downstream 100 bases:

>100_bases
GATCCTGTTGCAATGCGACAACCTGTGCAAACGCTATCAGGAAGGCAGTGTGCAAACCGATGTACTGCACAATGTCAGTT
TCAGCGTCGGCGAAGGTGAA

Product: outer membrane-specific lipoprotein transporter subunit LolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQL
PETAVKLDGVNRIAPVTTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQADLEPGKYNVILGEQLASQLGVNRGD
QIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGAS
AGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE

Sequences:

>Translated_399_residues
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQL
PETAVKLDGVNRIAPVTTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQADLEPGKYNVILGEQLASQLGVNRGD
QIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGAS
AGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
>Mature_399_residues
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNILGLMPQAILSSEHGSLNPQQL
PETAVKLDGVNRIAPVTTGDVVLQSARSVAVGVMLGIDPAQKDPLTPYLVNVKQADLEPGKYNVILGEQLASQLGVNRGD
QIRVMVPSASQFTPMGRIPSQRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAILQTQGLTPRQIMMVFMVQGAS
AGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAIEPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=399, Percent_Identity=99.2481203007519, Blast_Score=792, Evalue=0.0,
Organism=Escherichia coli, GI1787362, Length=416, Percent_Identity=27.4038461538462, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 43235; Mature: 43235

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMPQAILSSEHGSLNPQQLPETAVKLDGVNRIAPVTTGDVVLQSARSVAVGVMLGIDPA
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCC
QKDPLTPYLVNVKQADLEPGKYNVILGEQLASQLGVNRGDQIRVMVPSASQFTPMGRIPS
CCCCCCHHEEECCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCH
QRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
HHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHCC
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEE
QTQGLTPRQIMMVFMVQGASAGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAI
EECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEH
EPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHCCC
>Mature Secondary Structure
MYQPVALFIGLRYMRGRAADRFGRFVSWLSTIGITLGVMALVTVLSVMNGFERELQNNIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLMPQAILSSEHGSLNPQQLPETAVKLDGVNRIAPVTTGDVVLQSARSVAVGVMLGIDPA
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCC
QKDPLTPYLVNVKQADLEPGKYNVILGEQLASQLGVNRGDQIRVMVPSASQFTPMGRIPS
CCCCCCHHEEECCCCCCCCCCEEEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCH
QRLFNVIGTFAANSEVDGYEMLVNIEDASRLMRYPAGNITGWRLWLDEPLKVDSLSQQKL
HHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHHCC
PEGSKWQDWRDRKGELFQAVRMEKNMMGLLLSLIVAVAAFNIITSLGLMVMEKQGEVAIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEE
QTQGLTPRQIMMVFMVQGASAGIIGAILGAALGALLASQLNNLMPIIGVLLDGAALPVAI
EECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEH
EPLQVIVIALVAMAIALLSTLYPSWRAAATQPAEALRYE
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]