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The map label for this gene is pphA [H]

Identifier: 218548602

GI number: 218548602

Start: 1275377

End: 1276033

Strand: Direct

Name: pphA [H]

Synonym: EFER_1236

Alternate gene names: 218548602

Gene position: 1275377-1276033 (Clockwise)

Preceding gene: 218548601

Following gene: 218548608

Centisome position: 27.79

GC content: 47.95

Gene sequence:

>657_bases
ATGAAACAGCCTGCGCCCGTTTATCAGAGAATTGCGGGTCATCAATGGCGACATATCTGGCTTTCAGGTGATATACACGG
ATGTCTTGAGCAGTTGCGCCGCAAATTATGGCATTGTCGTTTTGATCCGTGGCGAGATTTACTTATCTCAGTGGGAGACG
TTATCGATCGTGGGCCGCAAAGTTTACGCTGTCTGCAGTTACTGGAGCAACGTTGGGTTCGTGCGGTAAGAGGCAATCAT
GAACAGATGGCGATGGATGCGCTGGCATCCCAGCAGATGTCGTTGTGGTTGATGAATGGCGGCGACTGGTTTGTTGAGTT
GGTAGATAATCAACAGAAACAAGCGAAAACAGCGCTGGAAAAATGTCAGTATTTGCCCTTTATTCTTGAAGTACACAGTT
GCACCGGCAAACATGTTATTGCGCATGCCGATTATCCTAATGATGTTTATGAATGGCAAAAGGACGTCGATTTGCATCAG
GTCTTGTGGAGCCGCTCACGATTACGTGAAGGCCCAAAAGGGAAGGAAATTACAGGTGCTGATCATTTCTGGTTTGGTCA
TACACCGTTGCGCCATCGCGTGGATATTGGCAACCTGCATTATATTGATACCGGCGCTGTCTTTGGGGGCGAACTGACTC
TCGTGCAACTGCAATAA

Upstream 100 bases:

>100_bases
CTTTATATTCAACCATAACACACACTCTACGGTCGTAGTCTAGCGTTTTTTAACATTCTTGTTAAAATTATGTGATCTTT
AGCGCGGGAGGAAAAAACTG

Downstream 100 bases:

>100_bases
TTAAAAATCACCGTATTCCTGTGCAGGTCGCCAGAAACCATCTATAAAATCCTCAATCGGAAAACAACCGCCATGGCGGA
TCCGTTGATCGTTCATAGAA

Product: serine/threonine protein phosphatase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKQPAPVYQRIAGHQWRHIWLSGDIHGCLEQLRRKLWHCRFDPWRDLLISVGDVIDRGPQSLRCLQLLEQRWVRAVRGNH
EQMAMDALASQQMSLWLMNGGDWFVELVDNQQKQAKTALEKCQYLPFILEVHSCTGKHVIAHADYPNDVYEWQKDVDLHQ
VLWSRSRLREGPKGKEITGADHFWFGHTPLRHRVDIGNLHYIDTGAVFGGELTLVQLQ

Sequences:

>Translated_218_residues
MKQPAPVYQRIAGHQWRHIWLSGDIHGCLEQLRRKLWHCRFDPWRDLLISVGDVIDRGPQSLRCLQLLEQRWVRAVRGNH
EQMAMDALASQQMSLWLMNGGDWFVELVDNQQKQAKTALEKCQYLPFILEVHSCTGKHVIAHADYPNDVYEWQKDVDLHQ
VLWSRSRLREGPKGKEITGADHFWFGHTPLRHRVDIGNLHYIDTGAVFGGELTLVQLQ
>Mature_218_residues
MKQPAPVYQRIAGHQWRHIWLSGDIHGCLEQLRRKLWHCRFDPWRDLLISVGDVIDRGPQSLRCLQLLEQRWVRAVRGNH
EQMAMDALASQQMSLWLMNGGDWFVELVDNQQKQAKTALEKCQYLPFILEVHSCTGKHVIAHADYPNDVYEWQKDVDLHQ
VLWSRSRLREGPKGKEITGADHFWFGHTPLRHRVDIGNLHYIDTGAVFGGELTLVQLQ

Specific function: Plays a key role in signaling protein misfolding via the CpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr an

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081988, Length=218, Percent_Identity=94.0366972477064, Blast_Score=419, Evalue=1e-119,
Organism=Escherichia coli, GI1789090, Length=217, Percent_Identity=42.8571428571429, Blast_Score=187, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 25431; Mature: 25431

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQPAPVYQRIAGHQWRHIWLSGDIHGCLEQLRRKLWHCRFDPWRDLLISVGDVIDRGPQ
CCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHH
SLRCLQLLEQRWVRAVRGNHEQMAMDALASQQMSLWLMNGGDWFVELVDNQQKQAKTALE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEEEEECCCEEEEECCCHHHHHHHHHH
KCQYLPFILEVHSCTGKHVIAHADYPNDVYEWQKDVDLHQVLWSRSRLREGPKGKEITGA
HHHHCHHHEEEECCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCC
DHFWFGHTPLRHRVDIGNLHYIDTGAVFGGELTLVQLQ
CCEEECCCCCHHEECCCCEEEEECCCEECCEEEEEEEC
>Mature Secondary Structure
MKQPAPVYQRIAGHQWRHIWLSGDIHGCLEQLRRKLWHCRFDPWRDLLISVGDVIDRGPQ
CCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHH
SLRCLQLLEQRWVRAVRGNHEQMAMDALASQQMSLWLMNGGDWFVELVDNQQKQAKTALE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCEEEEEEECCCEEEEECCCHHHHHHHHHH
KCQYLPFILEVHSCTGKHVIAHADYPNDVYEWQKDVDLHQVLWSRSRLREGPKGKEITGA
HHHHCHHHEEEECCCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCC
DHFWFGHTPLRHRVDIGNLHYIDTGAVFGGELTLVQLQ
CCEEECCCCCHHEECCCCEEEEECCCEECCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9130712; 9097040; 9278503 [H]