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The map label for this gene is edd [H]

Identifier: 218548588

GI number: 218548588

Start: 1263863

End: 1265674

Strand: Direct

Name: edd [H]

Synonym: EFER_1222

Alternate gene names: 218548588

Gene position: 1263863-1265674 (Clockwise)

Preceding gene: 218548587

Following gene: 218548589

Centisome position: 27.54

GC content: 51.05

Gene sequence:

>1812_bases
ATGAATCCGCAAATGTTACGCGTAACAAATCGCATTATAGAACGCTCACGAGAAACGCGTTCTGCTTACCTTGAGCGTAT
TGAACAAGCGAAAACTAACACCGTTCATCGCTCGCAACTGGCATGTGGCAACCTTGCACATGGTTTTGCCGCCTGTCAGC
CAGAAGATAAAGCCGCACTTAAAAGCATGTTGCGTAACAATATTGCGATCATCACCTCCTATAACGACATGCTTTCCGCC
CATCAGCCTTACGAACGTTACCCGGATATCATTCGCAAAGCGCTCCATGAAGTGAATGCGGTTGGTCAGGTTGCCGGTGG
TGTGCCAGCAATGTGTGACGGTGTGACTCAGGGCCAGGACGGGATGGAACTTTCCTTGCTGAGCCGCGAAGTCATTGCGA
TGTCTGCTGCAGTTGGGCTTTCACACAACATGTTTGATGGCGCGCTTTACCTTGGGGTATGTGACAAAATTGTTCCGGGG
CTGGCTATGGCCGCATTGTCTTTTGGGCATCTCCCGGCGGTGTTTGTACCATCAGGACCAATGGCAAGTGGTTTACCAAA
TAAAGAGAAAGTGCGTATCCGCCAGTTGTATGCTGAAGGCAAAGTAGATCGTATGGCACTTCTCGAATCAGAAGCCGCTT
CCTACCATGCACCAGGCACGTGTACTTTTTACGGTACGGCTAACACCAACCAGATGGTGGTGGAGTTTATGGGGATGCAA
TTACCCGGTTCCTCTTTCGTCCACCCGGATTCACCGCTGCGTGATGAGCTGACTGCTGCCGCTGCGCGCCAGGTCACGCG
TATGACCGGCAACGGTAGCGAATGGATGCCACTTGGTAAAATGATTGATGAAAAAGTTGTGGTAAACGGTATCGTTGCAC
TCCTGGCGACAGGTGGATCTACCAACCACACTATGCATCTGGTGGCCATGGCACGTGCCGCTGGTATTCAGATCAATTGG
GATGATTTCTCTGATCTTTCAGATGTTGTTCCTCTCCTGGCGCGTCTCTATCCTAATGGCCCGGCTGATATTAACCACTT
CCAGGCGGCAGGTGGTGTACCGGTGTTAATGCGTGAATTGCTGAATGCGGGTTTACTGCATGAAGATGTTAATACCGTGG
CAGGATTTGGCCTTTCTCGCTACACCATGGAGCCGTGGCTGAATAACGGTAAGCTGGATTGGCGTGAAGGGGCGGAAAAA
TCTCTCGACGACAATGTTATTGCGTCTTTCGATAAGCCTTTCTCGCATCATGGTGGCACCAAAGTATTAAGCGGTAACCT
GGGCCGGGCTGTCATGAAAACGTCTGCTGTCCCCCTTGAAAACCAGATTATTGAAGCGCCAGCAGTCGTATTTGAAAGCC
AACATGATGTTTTACCTGCCTTTGAAGCTGGAATGCTGGACCGGGATTGCGTCGTTGTTGTTCGCCACCAGGGGCCAAAA
GCGAACGGAATGCCAGAATTACATAAACTCATGCCGCCACTTGGTGTATTATTGGACCGCTGTTTCAAAATTGCGTTGGT
GACTGATGGACGGCTTTCTGGTGCTTCGGGTAAAGTGCCGTCAGCAATCCACGTGACACCGGAAGCCTACGATGGTGGGC
TGCTGGCAAAAGTACGTGATGGCGACATTATTCGAGTGAATGGTCAGACAGGCGAACTGACACTGCTGGTTGATGAAGCA
GAACTTGCCGCCCGTCAGCCTCATATTCCGAATCTGAGTGCATCGCGTATCGGGACCGGGCGTGAAATGTTTAGTGCTTT
ACGCGAAAAACTATCCGGTGCCGAGCAGGGCGCAACCTGTATCACCTTCTAA

Upstream 100 bases:

>100_bases
CTGTAGTGTTTTTGCTATGAGCTACGGTTAGCAGGCGTTTTATTCACTGAATTTCGCCTTGTTTTGCCTCCTGCTCAAAG
AATAAATTTCAGGAGCCATT

Downstream 100 bases:

>100_bases
AAGTTAAAATTTGTAATCAGGCGAGAGATAACTCTGATGAAAAACTGGAAAACAAGTGCGGAATCCATCCTGACCACTGG
CCCGGTAGTACCGGTTATTG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MNPQMLRVTNRIIERSRETRSAYLERIEQAKTNTVHRSQLACGNLAHGFAACQPEDKAALKSMLRNNIAIITSYNDMLSA
HQPYERYPDIIRKALHEVNAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPG
LAMAALSFGHLPAVFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDSPLRDELTAAAARQVTRMTGNGSEWMPLGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIQINW
DDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLMRELLNAGLLHEDVNTVAGFGLSRYTMEPWLNNGKLDWREGAEK
SLDDNVIASFDKPFSHHGGTKVLSGNLGRAVMKTSAVPLENQIIEAPAVVFESQHDVLPAFEAGMLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAARQPHIPNLSASRIGTGREMFSALREKLSGAEQGATCITF

Sequences:

>Translated_603_residues
MNPQMLRVTNRIIERSRETRSAYLERIEQAKTNTVHRSQLACGNLAHGFAACQPEDKAALKSMLRNNIAIITSYNDMLSA
HQPYERYPDIIRKALHEVNAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPG
LAMAALSFGHLPAVFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDSPLRDELTAAAARQVTRMTGNGSEWMPLGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIQINW
DDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLMRELLNAGLLHEDVNTVAGFGLSRYTMEPWLNNGKLDWREGAEK
SLDDNVIASFDKPFSHHGGTKVLSGNLGRAVMKTSAVPLENQIIEAPAVVFESQHDVLPAFEAGMLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAARQPHIPNLSASRIGTGREMFSALREKLSGAEQGATCITF
>Mature_603_residues
MNPQMLRVTNRIIERSRETRSAYLERIEQAKTNTVHRSQLACGNLAHGFAACQPEDKAALKSMLRNNIAIITSYNDMLSA
HQPYERYPDIIRKALHEVNAVGQVAGGVPAMCDGVTQGQDGMELSLLSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPG
LAMAALSFGHLPAVFVPSGPMASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
LPGSSFVHPDSPLRDELTAAAARQVTRMTGNGSEWMPLGKMIDEKVVVNGIVALLATGGSTNHTMHLVAMARAAGIQINW
DDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLMRELLNAGLLHEDVNTVAGFGLSRYTMEPWLNNGKLDWREGAEK
SLDDNVIASFDKPFSHHGGTKVLSGNLGRAVMKTSAVPLENQIIEAPAVVFESQHDVLPAFEAGMLDRDCVVVVRHQGPK
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRDGDIIRVNGQTGELTLLVDEA
ELAARQPHIPNLSASRIGTGREMFSALREKLSGAEQGATCITF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=95.3565505804312, Blast_Score=1202, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=542, Percent_Identity=30.2583025830258, Blast_Score=185, Evalue=8e-48,
Organism=Escherichia coli, GI2367371, Length=516, Percent_Identity=31.2015503875969, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1786464, Length=555, Percent_Identity=27.9279279279279, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=482, Percent_Identity=31.1203319502075, Blast_Score=179, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64866; Mature: 64866

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPQMLRVTNRIIERSRETRSAYLERIEQAKTNTVHRSQLACGNLAHGFAACQPEDKAAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHCCHHCCCCCHHHHH
KSMLRNNIAIITSYNDMLSAHQPYERYPDIIRKALHEVNAVGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPGLAMAALSFGHLPAVFVPSGP
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGSSFVHPDSPLRDELTAAAARQVTRMTGNGSEWMPLGKMIDEKVVVNGIVALLATGGS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TNHTMHLVAMARAAGIQINWDDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLMREL
CCCEEEHEEHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LNAGLLHEDVNTVAGFGLSRYTMEPWLNNGKLDWREGAEKSLDDNVIASFDKPFSHHGGT
HHCCCHHHHHHHHHCCCCHHEECCCCCCCCCCCHHCCCCCCCCCCHHHHCCCCHHHCCCC
KVLSGNLGRAVMKTSAVPLENQIIEAPAVVFESQHDVLPAFEAGMLDRDCVVVVRHQGPK
EEEECCCCHHHHHHCCCCHHHHHHHCCHHHCCCCCCCCCHHHHCCCCCCEEEEEECCCCC
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRD
CCCCHHHHHHCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEECC
GDIIRVNGQTGELTLLVDEAELAARQPHIPNLSASRIGTGREMFSALREKLSGAEQGATC
CCEEEEECCCCEEEEEEECHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCEE
ITF
ECC
>Mature Secondary Structure
MNPQMLRVTNRIIERSRETRSAYLERIEQAKTNTVHRSQLACGNLAHGFAACQPEDKAAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHCCHHCCCCCHHHHH
KSMLRNNIAIITSYNDMLSAHQPYERYPDIIRKALHEVNAVGQVAGGVPAMCDGVTQGQD
HHHHHCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
GMELSLLSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPGLAMAALSFGHLPAVFVPSGP
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLYAEGKVDRMALLESEAASYHAPGTCTFYGTANTNQMVVEFMGMQ
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGSSFVHPDSPLRDELTAAAARQVTRMTGNGSEWMPLGKMIDEKVVVNGIVALLATGGS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
TNHTMHLVAMARAAGIQINWDDFSDLSDVVPLLARLYPNGPADINHFQAAGGVPVLMREL
CCCEEEHEEHHHHCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHH
LNAGLLHEDVNTVAGFGLSRYTMEPWLNNGKLDWREGAEKSLDDNVIASFDKPFSHHGGT
HHCCCHHHHHHHHHCCCCHHEECCCCCCCCCCCHHCCCCCCCCCCHHHHCCCCHHHCCCC
KVLSGNLGRAVMKTSAVPLENQIIEAPAVVFESQHDVLPAFEAGMLDRDCVVVVRHQGPK
EEEECCCCHHHHHHCCCCHHHHHHHCCHHHCCCCCCCCCHHHHCCCCCCEEEEEECCCCC
ANGMPELHKLMPPLGVLLDRCFKIALVTDGRLSGASGKVPSAIHVTPEAYDGGLLAKVRD
CCCCHHHHHHCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEECC
GDIIRVNGQTGELTLLVDEAELAARQPHIPNLSASRIGTGREMFSALREKLSGAEQGATC
CCEEEEECCCCEEEEEEECHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCEE
ITF
ECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]