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The map label for this gene is asnC [H]

Identifier: 218548446

GI number: 218548446

Start: 1114888

End: 1116288

Strand: Reverse

Name: asnC [H]

Synonym: EFER_1074

Alternate gene names: 218548446

Gene position: 1116288-1114888 (Counterclockwise)

Preceding gene: 218548447

Following gene: 218548445

Centisome position: 24.33

GC content: 52.96

Gene sequence:

>1401_bases
ATGAGCGTTGTGCCTGTAGCCGACGTACTCCAGGGCCGTGTAGCCGTTGACAGCGAAGTCACCGTGCGCGGATGGGTACG
TACCCGCCGAGATTCAAAAGCTGGCATCTCCTTCCTCGCCGTTTATGACGGTTCCTGCTTTGATCCTGTACAGGCTGTCA
TCAATAATTCTCTGCCCAATTACAATGAAGACGTCCTGCGTCTGACCACCGGTTGCTCGGTCATTGTGACGGGTAAAGTC
GTGGCGTCTCCAGGCCAGGGGCAACAATTTGAAATTCAGGCCAGCAAGGTTGAAGTTGCTGGTTGGGTTGAAGATCCAGA
CACTTACCCGATGGCGGCAAAACGCCACAGCATTGAGTATCTGCGTGAAGTCGCTCACCTGCGTCCGCGCACAAACCTGA
TTGGTGCCGTCGCGCGCGTTCGCCATACGTTGGCGCAGGCGCTGCATCGCTTCTTTAACGAGCAGGGGTTCTTCTGGGTT
TCAACGCCACTGATTACTGCGTCTGATACCGAAGGTGCTGGCGAAATGTTCCGCGTTTCTACGCTGGATCTGGAAAACCT
GCCGCGTAACGATCAGGGCAAAGTGGATTTCGACAAAGACTTCTTCGGTAAAGAGTCTTTCCTGACCGTATCTGGTCAGT
TGAACGGCGAGACCTACGCTTGCGCATTGTCTAAAATTTATACCTTCGGCCCGACTTTCCGTGCTGAAAACTCCAACACC
AGCCGTCACCTGGCGGAATTCTGGATGCTGGAGCCGGAAGTGGCGTTTGCTAACCTGAACGATATCGCGGGTCTGGCTGA
AGCCATGCTGAAATATGTCTTCAAAGCGGTTCTCGAAGAGCGCGCAGACGACATGAAATTCTTCGCTGAACGCGTAGATA
AAGATGCCGTTTCACGTCTGGAACGCTTCATTGAGGCCGATTTCGCGCAGGTGGATTACACCGACGCAGTGACCATTCTC
GAAAACTGCGGTAAGAAATTTGAGAACCCGGTTTACTGGGGCGTTGATCTCTCTTCTGAGCATGAACGTTATCTGGCGGA
AGAACACTTTAAAGCACCGGTAGTGGTTAAAAACTATCCGAAAGACATTAAAGCGTTCTATATGCGCCTTAACGAAGACG
GAAAAACCGTTGCGGCAATGGACGTTCTGGCACCGGGCATCGGTGAGATCATCGGTGGTTCCCAGCGTGAAGAGCGTCTG
GATGTGCTGGACGAGCGTATGCTGGAAATGGGCCTGAACAAAGAGGATTACTGGTGGTATCGCGATCTGCGTCGCTACGG
AACTGTTCCGCATTCCGGATTCGGTCTTGGTTTTGAACGCCTGATTGCTTACGTAACAGGCGTGCAGAACGTGCGTGACG
TGATTCCGTTCCCGCGTACTCCGCGTAACGCCAGCTTCTAA

Upstream 100 bases:

>100_bases
ATTCTGCTTGTCTGATTGCAGATGCCAGGTAACATAGGTATCCCCCCATTGAAGGGTGGACAAGTGTTTATTTTTTCCGA
CTATTAACAGAGAGAATATT

Downstream 100 bases:

>100_bases
TTACATTTCATATGCAAAAAGCCAGCACCTGTTGCTGGCTTTTTTTCGCTTATTCACTTCTATAACGTCAATTTTTGTCA
GCACATCGCAAACAAATTTC

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPNYNEDVLRLTTGCSVIVTGKV
VASPGQGQQFEIQASKVEVAGWVEDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWV
STPLITASDTEGAGEMFRVSTLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNT
SRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRLERFIEADFAQVDYTDAVTIL
ENCGKKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERL
DVLDERMLEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF

Sequences:

>Translated_466_residues
MSVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPNYNEDVLRLTTGCSVIVTGKV
VASPGQGQQFEIQASKVEVAGWVEDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWV
STPLITASDTEGAGEMFRVSTLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNT
SRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRLERFIEADFAQVDYTDAVTIL
ENCGKKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERL
DVLDERMLEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF
>Mature_465_residues
SVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPNYNEDVLRLTTGCSVIVTGKVV
ASPGQGQQFEIQASKVEVAGWVEDPDTYPMAAKRHSIEYLREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWVS
TPLITASDTEGAGEMFRVSTLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNTS
RHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRLERFIEADFAQVDYTDAVTILE
NCGKKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYPKDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLD
VLDERMLEMGLNKEDYWWYRDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI226491502, Length=463, Percent_Identity=41.9006479481641, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI4758762, Length=455, Percent_Identity=28.1318681318681, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI45439306, Length=350, Percent_Identity=29.4285714285714, Blast_Score=129, Evalue=8e-30,
Organism=Escherichia coli, GI1787161, Length=466, Percent_Identity=99.7854077253219, Blast_Score=963, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=472, Percent_Identity=21.3983050847458, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788173, Length=111, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984122, Length=471, Percent_Identity=28.4501061571125, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17556372, Length=433, Percent_Identity=31.1778290993072, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17551876, Length=342, Percent_Identity=27.4853801169591, Blast_Score=115, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319872, Length=470, Percent_Identity=36.3829787234043, Blast_Score=289, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6321807, Length=457, Percent_Identity=29.9781181619256, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6323011, Length=487, Percent_Identity=24.6406570841889, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI19922416, Length=464, Percent_Identity=35.5603448275862, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI19921528, Length=467, Percent_Identity=29.1220556745182, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17136276, Length=490, Percent_Identity=26.734693877551, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.22 [H]

Molecular weight: Translated: 52543; Mature: 52412

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPN
CCCCCHHHHHCCCEECCCCEEEHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCC
YNEDVLRLTTGCSVIVTGKVVASPGQGQQFEIQASKVEVAGWVEDPDTYPMAAKRHSIEY
CCCHHHEEECCCEEEEECEEEECCCCCCEEEEEECEEEEEEECCCCCCCCCHHHHHHHHH
LREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWVSTPLITASDTEGAGEMFRVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCEEEEE
TLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNT
EECHHHCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCC
SRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRL
HHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ERFIEADFAQVDYTDAVTILENCGKKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYP
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCC
KDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDERMLEMGLNKEDYWWY
HHHHHHHHHCCCCCCEEEHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
RDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SVVPVADVLQGRVAVDSEVTVRGWVRTRRDSKAGISFLAVYDGSCFDPVQAVINNSLPN
CCCCHHHHHCCCEECCCCEEEHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCC
YNEDVLRLTTGCSVIVTGKVVASPGQGQQFEIQASKVEVAGWVEDPDTYPMAAKRHSIEY
CCCHHHEEECCCEEEEECEEEECCCCCCEEEEEECEEEEEEECCCCCCCCCHHHHHHHHH
LREVAHLRPRTNLIGAVARVRHTLAQALHRFFNEQGFFWVSTPLITASDTEGAGEMFRVS
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCEEEECCCCCCCCEEEEE
TLDLENLPRNDQGKVDFDKDFFGKESFLTVSGQLNGETYACALSKIYTFGPTFRAENSNT
EECHHHCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEECCCCCC
SRHLAEFWMLEPEVAFANLNDIAGLAEAMLKYVFKAVLEERADDMKFFAERVDKDAVSRL
HHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
ERFIEADFAQVDYTDAVTILENCGKKFENPVYWGVDLSSEHERYLAEEHFKAPVVVKNYP
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEECCCC
KDIKAFYMRLNEDGKTVAAMDVLAPGIGEIIGGSQREERLDVLDERMLEMGLNKEDYWWY
HHHHHHHHHCCCCCCEEEHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHH
RDLRRYGTVPHSGFGLGFERLIAYVTGVQNVRDVIPFPRTPRNASF
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA