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The map label for this gene is deoR [H]

Identifier: 218548359

GI number: 218548359

Start: 1014076

End: 1014873

Strand: Reverse

Name: deoR [H]

Synonym: EFER_0981

Alternate gene names: 218548359

Gene position: 1014873-1014076 (Counterclockwise)

Preceding gene: 218548360

Following gene: 218548357

Centisome position: 22.12

GC content: 47.37

Gene sequence:

>798_bases
GTGTTCGACTGCGCGCTTAAATTATTCTTCAGAGGGATTATGGAAACACGTCGTGACGAGCGTATTAGTCAATTATTACA
GGCGTTAAAACGCAGCGATAAACTTCATCTTAAAGAGGCCGCTACCTTGTTGGGTGTGTCGGAGATGACCATTCGCCGCG
ATCTGAATAATAACAATGCCCCTGTAGTCTTACTGGGCGGTTATATTGTTCTGGAGCCACGCAGTGCCAGCCACTATCTG
TTAAGCGATCAAAAATCACGGCTGGTCGAAGAAAAACGTCGCGCGGCTCAACAGGCTGCTGAACTTGTACAACCACATCA
GACGCTGTTTTTCGACTGCGGCACCACGACGCCCTGGATTATAGAAGCCATCAATAAGGATATTCCCTTTACGGCAGTGT
GTTATTCGCTGAATACCTTCATGGCACTACAAGAGAAACCACATTGCCGGGCAATACTCTGTGGTGGCGAATTTCATGCC
AGTAACGCAATTTTCAAGCCACTTAGCTTTCAGGAAACGCTTAATAACATCTGCCCAGATATTGCCTTCTACTCCGCAGC
AGGCGTGCATGTCAGTAAAGGGGCAACCTGTTTTAATCTCGAAGAGCTGCCGGTAAAACACTGGGCGATGTCGATGGCGC
AACAACATGTACTGGTGGTGGATCACAGTAAATTCGGTAAAGTACGCCCGGCACGAATGGGCGATTTAAAACAGTTTGAT
GTGCTGGCGAGTGACTGTCGCCCGGATGATGAAATTATTGAGTACGCGAAAGCGCATAATATCAGGTTACTGTATTAA

Upstream 100 bases:

>100_bases
CACTTCTGCAAACAGGTTATCGGGCATGCTTCGCCCTGCCGATTCGCAAAGGCTGGGTGCGTGACTGATATCTGGTAATA
CGTGTAGTATTAAGCGCTCA

Downstream 100 bases:

>100_bases
CCCCGTTGCGCCGGATAGTCTCATGTACCCTCCGGCGCGTCCACCGATTACGAGAACCAACCGCCAAACCACTGGTGGAA
TTTCATCATCACGAAATCCC

Product: DNA-binding transcriptional repressor DeoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MFDCALKLFFRGIMETRRDERISQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNNNNAPVVLLGGYIVLEPRSASHYL
LSDQKSRLVEEKRRAAQQAAELVQPHQTLFFDCGTTTPWIIEAINKDIPFTAVCYSLNTFMALQEKPHCRAILCGGEFHA
SNAIFKPLSFQETLNNICPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQQHVLVVDHSKFGKVRPARMGDLKQFD
VLASDCRPDDEIIEYAKAHNIRLLY

Sequences:

>Translated_265_residues
MFDCALKLFFRGIMETRRDERISQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNNNNAPVVLLGGYIVLEPRSASHYL
LSDQKSRLVEEKRRAAQQAAELVQPHQTLFFDCGTTTPWIIEAINKDIPFTAVCYSLNTFMALQEKPHCRAILCGGEFHA
SNAIFKPLSFQETLNNICPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQQHVLVVDHSKFGKVRPARMGDLKQFD
VLASDCRPDDEIIEYAKAHNIRLLY
>Mature_265_residues
MFDCALKLFFRGIMETRRDERISQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNNNNAPVVLLGGYIVLEPRSASHYL
LSDQKSRLVEEKRRAAQQAAELVQPHQTLFFDCGTTTPWIIEAINKDIPFTAVCYSLNTFMALQEKPHCRAILCGGEFHA
SNAIFKPLSFQETLNNICPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQQHVLVVDHSKFGKVRPARMGDLKQFD
VLASDCRPDDEIIEYAKAHNIRLLY

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=252, Percent_Identity=84.9206349206349, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1789829, Length=250, Percent_Identity=26.8, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789519, Length=234, Percent_Identity=26.0683760683761, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788069, Length=249, Percent_Identity=22.8915662650602, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI226510968, Length=229, Percent_Identity=28.82096069869, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790753, Length=243, Percent_Identity=25.1028806584362, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787540, Length=240, Percent_Identity=25.4166666666667, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789059, Length=234, Percent_Identity=24.7863247863248, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 29978; Mature: 29978

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDCALKLFFRGIMETRRDERISQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNNNNA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
PVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKRRAAQQAAELVQPHQTLFFDCGTTTPWI
CEEEECCEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
IEAINKDIPFTAVCYSLNTFMALQEKPHCRAILCGGEFHASNAIFKPLSFQETLNNICPD
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCCEECCCCHHHHHHHHCCH
IAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQQHVLVVDHSKFGKVRPARMGDLKQFD
HHHHHCCCEEEECCCEEECHHHCCHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCHHHHH
VLASDCRPDDEIIEYAKAHNIRLLY
HHHHCCCCHHHHHHHHHHCCEEEEC
>Mature Secondary Structure
MFDCALKLFFRGIMETRRDERISQLLQALKRSDKLHLKEAATLLGVSEMTIRRDLNNNNA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
PVVLLGGYIVLEPRSASHYLLSDQKSRLVEEKRRAAQQAAELVQPHQTLFFDCGTTTPWI
CEEEECCEEEECCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
IEAINKDIPFTAVCYSLNTFMALQEKPHCRAILCGGEFHASNAIFKPLSFQETLNNICPD
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEECCCCEECCCCHHHHHHHHCCH
IAFYSAAGVHVSKGATCFNLEELPVKHWAMSMAQQHVLVVDHSKFGKVRPARMGDLKQFD
HHHHHCCCEEEECCCEEECHHHCCHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCHHHHH
VLASDCRPDDEIIEYAKAHNIRLLY
HHHHCCCCHHHHHHHHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]