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The map label for this gene is gcvR [H]

Identifier: 218548087

GI number: 218548087

Start: 713774

End: 714346

Strand: Reverse

Name: gcvR [H]

Synonym: EFER_0696

Alternate gene names: 218548087

Gene position: 714346-713774 (Counterclockwise)

Preceding gene: 218548094

Following gene: 218548086

Centisome position: 15.57

GC content: 48.34

Gene sequence:

>573_bases
TTGACACCGTCATCACAACACTACCTCGTTATCACAGCACTGGGGGCCGATCGCCCCGGGATCGTGAATACGATCACACG
TCACGTCAGTAGTTGTGGCTGTAATATTGAAGACAGTCGACTGGCGATGCTGGGGGACGAGTTCACCTTTATTATGCTGC
TTTCTGGCTCATGGAATGCCATTACCCTTATTGAATCAACCCTGCCGTTGAAAGGCGCAGAGCTGGATCTCCTCATTGTG
ATGAAGCGAACCTCCGCCAGACCTCGTCCGCCGATGCCCGCTACGGTATGGGTACAGGTTGATGTGCCAGACTCGCCGCA
TTTAATTGAGCGTTTTACGGCGCTTTTTGACAACCACAAGATGAACATTGCGGAACTGGTTTCACGCACGCAACCAGCTG
AAAACGATAATGTTGCACAACTTCATATTCAGATCACCGCGCACAGTCCGGCATCACATGATTCGGTAAATATTGAGCAA
GACTTCAAAGCGCTATGTACAGAATTGAATGCACAAGGCAGTATTAGTGTCGTCAATTATTCACATACTGATGAACAGAA
TGGAGTTAAGTAA

Upstream 100 bases:

>100_bases
TGGCAATAAAAGCAAGTGACGAGAGACCTGTTGCTTGTTGTATGCCAGTTTTTTTTATGCTTTCCTTATGATTACCTCAC
CTCTCAAAGGAATAACAGGT

Downstream 100 bases:

>100_bases
TGAATCCACTGAAAGCCGGTGACATCGCACCGAAATTTAGCTTGCCGGATCAAGACGGGGAACAAGTAAATTTAACCGAC
TTCCAGGGACAGCGTGTTCT

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MTPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNAITLIESTLPLKGAELDLLIV
MKRTSARPRPPMPATVWVQVDVPDSPHLIERFTALFDNHKMNIAELVSRTQPAENDNVAQLHIQITAHSPASHDSVNIEQ
DFKALCTELNAQGSISVVNYSHTDEQNGVK

Sequences:

>Translated_190_residues
MTPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNAITLIESTLPLKGAELDLLIV
MKRTSARPRPPMPATVWVQVDVPDSPHLIERFTALFDNHKMNIAELVSRTQPAENDNVAQLHIQITAHSPASHDSVNIEQ
DFKALCTELNAQGSISVVNYSHTDEQNGVK
>Mature_189_residues
TPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNAITLIESTLPLKGAELDLLIVM
KRTSARPRPPMPATVWVQVDVPDSPHLIERFTALFDNHKMNIAELVSRTQPAENDNVAQLHIQITAHSPASHDSVNIEQD
FKALCTELNAQGSISVVNYSHTDEQNGVK

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=190, Percent_Identity=90.5263157894737, Blast_Score=357, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 20870; Mature: 20739

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNA
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCE
ITLIESTLPLKGAELDLLIVMKRTSARPRPPMPATVWVQVDVPDSPHLIERFTALFDNHK
EEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCC
MNIAELVSRTQPAENDNVAQLHIQITAHSPASHDSVNIEQDFKALCTELNAQGSISVVNY
CCHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
SHTDEQNGVK
CCCCCCCCCC
>Mature Secondary Structure 
TPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNA
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCE
ITLIESTLPLKGAELDLLIVMKRTSARPRPPMPATVWVQVDVPDSPHLIERFTALFDNHK
EEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCC
MNIAELVSRTQPAENDNVAQLHIQITAHSPASHDSVNIEQDFKALCTELNAQGSISVVNY
CCHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEE
SHTDEQNGVK
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]