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The map label for this gene is penA [H]

Identifier: 218532978

GI number: 218532978

Start: 5467613

End: 5469490

Strand: Reverse

Name: penA [H]

Synonym: Mchl_5102

Alternate gene names: 218532978

Gene position: 5469490-5467613 (Counterclockwise)

Preceding gene: 218532979

Following gene: 218532977

Centisome position: 94.66

GC content: 67.89

Gene sequence:

>1878_bases
GTGTCCCACGATCCTTCCCAGGAAGATCCGTCGCAGGAAGGTCCGTCGCCGGGCCTGCAGCACGAGCAGCCGGACGCGCT
CGCGGCCGATGCCGCCGTGCCGGAGCCGGGCGCGGACCGGGTGGTGCGGAGCGAGCCGCCGGTCTCGGCGCTGACGCGGC
TCACCCGGATCATGTTCCGTCTTGCCATCGAGCGCTCGCATGCCCGCGTGGCGCTGGTCGGCCTCGCGTTCACGGCGGTG
TTCGTCACCATCAGCGTGCGGCTGATCGTGATGGCGGCAACGCCTGCGAGCAACAGCGACGAGCACCGGGTGGCGGCCGC
CGCCACCACCGCGATCCGCCCCGATATCATTGACCGCAACGGCGAGATCCTGGCCACCGACATCCGCACCGTCTCGGTCT
TCGCCGAGCCGAAGCGGATGGTGCGCACCTTCGACACCGACGAGGCTGTCGAACTCCTGACCGCCGTGCTGCCCGAGCTG
AATGCGGCCGAGCTGCGCGCCAAGCTGTCCTCGAAGAAGGGCTTCGTCTGGATCAAGCGCGAGATCACGCCGAAGCAGCA
GCTCGAAGTCCACCGCCTCGGCATCCCCGGCGTCGGCTTCCTGCCCGACCACAAGCGCGTCTACCCGAACGGGGTCGCGG
CCGCGCACGTCATCGGCGCGACGAACCTCGACAATATCGGCATCGCCGGCATCGAGAAGTACATCGACAACCGCGGCAAC
AAGGCGCTCAACGAGTTCGGCCTCGTGGCCAAGCAGACCGACCTCTCGCCGATCCAACTCTCCCTCGACCTGCGCGCCCA
GTTCGCCCTGCGCGACGAGCTCGTGAAGGGCGTGGAGAAGTTCAAGGCCAAGGCCGGCGCCTCGATGATCCTCGACGTGA
CCACCGGCGAGGTCGTCGCGCTCGCCTCCTACCCGGATTTCGACCCCAACGAGCCGAAGGATGCGCTCTCGGACGACCGC
ATCAATCGGATGAATGTCGGCGTCTACGAGATGGGCTCGACCTTCAAGGCGATGACGCTCGCCATGGCGCTCGATTCCGG
CAAGTACAACGTCAACTCGACCTTCGACACCCGCGGCGGCGTGCTGCACTGGGGCCGGCAGAAGATCCACGACTACCACG
CCACGGGGCGCGTGCTGACGATGCCGGAGGTGTTCACCCACTCCTCCAACATCGGCTCGGCCAAGATGGCGCTCGGCGTC
GGCGTGCCCGGCCACCGCGCCTTCCTCAAGAAGATGGGCCTGCTCGACCGGATGCGGACCGAGCTGCCGGAATCGGCTTC
GCCGATCCTTCCGCCGCGCTGGGCCGAGATCAACACCATCACCATCGCCTTCGGCCACGGCATCGCGGTGGCGCCGATCC
AGGCGGCGGCGGCGGTGGCGGCGATCATCAACGGCGGCGACCTGATGACGCCGACCTTCCTGAAGACCGACGAGCCGACG
GCACGGGGCAAGGCCAGCCACGTGATGAAGCCGGAGGCCAGCGAGGCGATGCGCTTCATCATGCGCCTCAACGCGGTCGA
GGGCTCGGCCAAGAAGGCGTCGATCCCGCTCTACTACGTCGGCGGCAAGACCGGCACGGCCGAGAAGGTCATCAACGGGC
GCTACGCCAAGAACCGCCTGTTCACGACCTTCATGGCCGCGGCGCCGATGGACAAGCCGAAATACCTGTTCCTGACGATC
ATGGACGAGCCGCAGGGCCTGCCCGAGACCGGCGGCTACGCCACGGCCGCCTACAATTCCGGCACGGTGACGGGCAAGAT
CATCGAGCGGGCCGCGCCGATCCTCGGGCTGGCACCGCGCTTCGATCCGCCGGTGAAGCCGTTCCCGCTGATGGTGAAGC
TCGGCGCCTACCATGCGACCATGGTGGACGGGCAGTGA

Upstream 100 bases:

>100_bases
GACAAGCCGGGAAGCGCCCGCGACGAGCCGCGCACCACCGGCTCCGTCACCACCCGCACCGTCTCCACCCGCCCGCCCGC
GGTTTCGAGGTAGCGTCCCC

Downstream 100 bases:

>100_bases
CGGCAGCCTGTACCCCGTCGGCCTGACCCGCACGGACGCTTCCGAGGATTGTTTTGCCGATGAGCCAGCCGACGCCTGAC
GACCGGACTCTCGGCGCGCT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MSHDPSQEDPSQEGPSPGLQHEQPDALAADAAVPEPGADRVVRSEPPVSALTRLTRIMFRLAIERSHARVALVGLAFTAV
FVTISVRLIVMAATPASNSDEHRVAAAATTAIRPDIIDRNGEILATDIRTVSVFAEPKRMVRTFDTDEAVELLTAVLPEL
NAAELRAKLSSKKGFVWIKREITPKQQLEVHRLGIPGVGFLPDHKRVYPNGVAAAHVIGATNLDNIGIAGIEKYIDNRGN
KALNEFGLVAKQTDLSPIQLSLDLRAQFALRDELVKGVEKFKAKAGASMILDVTTGEVVALASYPDFDPNEPKDALSDDR
INRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTFDTRGGVLHWGRQKIHDYHATGRVLTMPEVFTHSSNIGSAKMALGV
GVPGHRAFLKKMGLLDRMRTELPESASPILPPRWAEINTITIAFGHGIAVAPIQAAAAVAAIINGGDLMTPTFLKTDEPT
ARGKASHVMKPEASEAMRFIMRLNAVEGSAKKASIPLYYVGGKTGTAEKVINGRYAKNRLFTTFMAAAPMDKPKYLFLTI
MDEPQGLPETGGYATAAYNSGTVTGKIIERAAPILGLAPRFDPPVKPFPLMVKLGAYHATMVDGQ

Sequences:

>Translated_625_residues
MSHDPSQEDPSQEGPSPGLQHEQPDALAADAAVPEPGADRVVRSEPPVSALTRLTRIMFRLAIERSHARVALVGLAFTAV
FVTISVRLIVMAATPASNSDEHRVAAAATTAIRPDIIDRNGEILATDIRTVSVFAEPKRMVRTFDTDEAVELLTAVLPEL
NAAELRAKLSSKKGFVWIKREITPKQQLEVHRLGIPGVGFLPDHKRVYPNGVAAAHVIGATNLDNIGIAGIEKYIDNRGN
KALNEFGLVAKQTDLSPIQLSLDLRAQFALRDELVKGVEKFKAKAGASMILDVTTGEVVALASYPDFDPNEPKDALSDDR
INRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTFDTRGGVLHWGRQKIHDYHATGRVLTMPEVFTHSSNIGSAKMALGV
GVPGHRAFLKKMGLLDRMRTELPESASPILPPRWAEINTITIAFGHGIAVAPIQAAAAVAAIINGGDLMTPTFLKTDEPT
ARGKASHVMKPEASEAMRFIMRLNAVEGSAKKASIPLYYVGGKTGTAEKVINGRYAKNRLFTTFMAAAPMDKPKYLFLTI
MDEPQGLPETGGYATAAYNSGTVTGKIIERAAPILGLAPRFDPPVKPFPLMVKLGAYHATMVDGQ
>Mature_624_residues
SHDPSQEDPSQEGPSPGLQHEQPDALAADAAVPEPGADRVVRSEPPVSALTRLTRIMFRLAIERSHARVALVGLAFTAVF
VTISVRLIVMAATPASNSDEHRVAAAATTAIRPDIIDRNGEILATDIRTVSVFAEPKRMVRTFDTDEAVELLTAVLPELN
AAELRAKLSSKKGFVWIKREITPKQQLEVHRLGIPGVGFLPDHKRVYPNGVAAAHVIGATNLDNIGIAGIEKYIDNRGNK
ALNEFGLVAKQTDLSPIQLSLDLRAQFALRDELVKGVEKFKAKAGASMILDVTTGEVVALASYPDFDPNEPKDALSDDRI
NRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTFDTRGGVLHWGRQKIHDYHATGRVLTMPEVFTHSSNIGSAKMALGVG
VPGHRAFLKKMGLLDRMRTELPESASPILPPRWAEINTITIAFGHGIAVAPIQAAAAVAAIINGGDLMTPTFLKTDEPTA
RGKASHVMKPEASEAMRFIMRLNAVEGSAKKASIPLYYVGGKTGTAEKVINGRYAKNRLFTTFMAAAPMDKPKYLFLTIM
DEPQGLPETGGYATAAYNSGTVTGKIIERAAPILGLAPRFDPPVKPFPLMVKLGAYHATMVDGQ

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=514, Percent_Identity=29.5719844357977, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1786854, Length=592, Percent_Identity=25.5067567567568, Blast_Score=93, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 67393; Mature: 67262

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDPSQEDPSQEGPSPGLQHEQPDALAADAAVPEPGADRVVRSEPPVSALTRLTRIMFR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LAIERSHARVALVGLAFTAVFVTISVRLIVMAATPASNSDEHRVAAAATTAIRPDIIDRN
HHHHCCCCEEEEHHHHHHHHHHHHEEEEEEEEECCCCCCCCCEEHHHHHHHCCCCCCCCC
GEILATDIRTVSVFAEPKRMVRTFDTDEAVELLTAVLPELNAAELRAKLSSKKGFVWIKR
CCEEEEEEEEEEEECCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEE
EITPKQQLEVHRLGIPGVGFLPDHKRVYPNGVAAAHVIGATNLDNIGIAGIEKYIDNRGN
CCCCHHHCEEEECCCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCC
KALNEFGLVAKQTDLSPIQLSLDLRAQFALRDELVKGVEKFKAKAGASMILDVTTGEVVA
HHHHHHCCEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEE
LASYPDFDPNEPKDALSDDRINRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTFDTRGG
EECCCCCCCCCCHHHHCCCCCCEEECCCEECCCHHHHHEEEEEECCCCEECCCCCCCCCC
VLHWGRQKIHDYHATGRVLTMPEVFTHSSNIGSAKMALGVGVPGHRAFLKKMGLLDRMRT
EEECCHHHHHHHHCCCCEEECCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
ELPESASPILPPRWAEINTITIAFGHGIAVAPIQAAAAVAAIINGGDLMTPTFLKTDEPT
HCCCCCCCCCCCCCCCEEEEEEEECCCEEECHHHHHHHHHHHCCCCCCCCCCEEECCCCC
ARGKASHVMKPEASEAMRFIMRLNAVEGSAKKASIPLYYVGGKTGTAEKVINGRYAKNRL
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHCCCHHHHHH
FTTFMAAAPMDKPKYLFLTIMDEPQGLPETGGYATAAYNSGTVTGKIIERAAPILGLAPR
HHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCEECCCC
FDPPVKPFPLMVKLGAYHATMVDGQ
CCCCCCCCCEEEEECCEEEEEECCC
>Mature Secondary Structure 
SHDPSQEDPSQEGPSPGLQHEQPDALAADAAVPEPGADRVVRSEPPVSALTRLTRIMFR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LAIERSHARVALVGLAFTAVFVTISVRLIVMAATPASNSDEHRVAAAATTAIRPDIIDRN
HHHHCCCCEEEEHHHHHHHHHHHHEEEEEEEEECCCCCCCCCEEHHHHHHHCCCCCCCCC
GEILATDIRTVSVFAEPKRMVRTFDTDEAVELLTAVLPELNAAELRAKLSSKKGFVWIKR
CCEEEEEEEEEEEECCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEE
EITPKQQLEVHRLGIPGVGFLPDHKRVYPNGVAAAHVIGATNLDNIGIAGIEKYIDNRGN
CCCCHHHCEEEECCCCCCCCCCCCCEECCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCC
KALNEFGLVAKQTDLSPIQLSLDLRAQFALRDELVKGVEKFKAKAGASMILDVTTGEVVA
HHHHHHCCEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEE
LASYPDFDPNEPKDALSDDRINRMNVGVYEMGSTFKAMTLAMALDSGKYNVNSTFDTRGG
EECCCCCCCCCCHHHHCCCCCCEEECCCEECCCHHHHHEEEEEECCCCEECCCCCCCCCC
VLHWGRQKIHDYHATGRVLTMPEVFTHSSNIGSAKMALGVGVPGHRAFLKKMGLLDRMRT
EEECCHHHHHHHHCCCCEEECCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHH
ELPESASPILPPRWAEINTITIAFGHGIAVAPIQAAAAVAAIINGGDLMTPTFLKTDEPT
HCCCCCCCCCCCCCCCEEEEEEEECCCEEECHHHHHHHHHHHCCCCCCCCCCEEECCCCC
ARGKASHVMKPEASEAMRFIMRLNAVEGSAKKASIPLYYVGGKTGTAEKVINGRYAKNRL
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHCCCHHHHHH
FTTFMAAAPMDKPKYLFLTIMDEPQGLPETGGYATAAYNSGTVTGKIIERAAPILGLAPR
HHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCCEECCCC
FDPPVKPFPLMVKLGAYHATMVDGQ
CCCCCCCCCEEEEECCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]