Click here to switch to the map view.

The map label for this gene is hisN [H]

Identifier: 218532896

GI number: 218532896

Start: 5365016

End: 5365807

Strand: Reverse

Name: hisN [H]

Synonym: Mchl_5019

Alternate gene names: 218532896

Gene position: 5365807-5365016 (Counterclockwise)

Preceding gene: 218532897

Following gene: 218532893

Centisome position: 92.87

GC content: 70.45

Gene sequence:

>792_bases
ATGAGCGTCGTCGATCTCGCCCAGTTCATGGAAGACCTCGCCACCCAGTCCGGAGCGGCGATCCTGCCGTTCTTCCGGGC
GCATTTCGGCCTGGACGACAAGTCCCACGGCACGGGCCACGCCTTCGACCCGGTCACCGAGGCGGACCGCGCGGCGGAAG
CGGTGATGCGGCGGATGATCAACGACCGGCTGCCGAACCACGGCATCCTCGGCGAGGAATTCGGCTCCGAGCGGGCGGAT
GCGGAATGCGTCTGGGTGCTCGACCCGATCGACGGCACCCGCGCCTTCATCAGCGGCCTGCCGACCTGGGGCACGCTGAT
CGGGCTGACCCATCACGGCGCGGCGGTGCGCGGCCTGATGCACCAGCCCTATCTCGGCGAGCGCTTCCTCGGCGACGGCA
AGACCGCGAGCGTGCGCTCCGCGAAGGGCGAACGCCCCCTCCACACCCGCCGCAACGAGGCACTCGGTAACGCCATCCTC
GCCACCACCGACCCGCGCCTGTTCGCGCAAGGGGAGGAGGCCGAGCGGTTCCGGACGATCGAGGGGCAGGTGAAGATGTC
CCGCTACGGCACCGATTGCTACGCCTATTGCATGCTCGCCGCCGGCCAGATCGACCTCGTGGTCGAAGCGGGGCTGAAGC
CCTACGACATCGTCGCGCTGATCCCCATCGTCGAGGGCGCGGGCGGCCTCGTCACGAGTTGGGACGGCGGCCCGGCCACC
GGCGGCGGCCGAATCGTGGCCGCCGGAGACCGCCGGCTGCACGAGGCGGCGCTGAAGGTGCTCAACCCGTAG

Upstream 100 bases:

>100_bases
GATGCGGCCACGCCCCCGCGGCAGGCCCTGCCCGAGCCGGCTTGACGAGACGGCTTGAGGGCGGCTTCGTCTCAGCCCGT
CAATGGGAGGCTGCCCCTCG

Downstream 100 bases:

>100_bases
GGCCCCGCCCCGGAGGGAAGGGCGCCGGGTGATCGCACGACGCGGACGAGCCGCCCCGATCGCGACGGCGAACGGGAACG
GCTCGCATGGGTTCTCGCGC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSVVDLAQFMEDLATQSGAAILPFFRAHFGLDDKSHGTGHAFDPVTEADRAAEAVMRRMINDRLPNHGILGEEFGSERAD
AECVWVLDPIDGTRAFISGLPTWGTLIGLTHHGAAVRGLMHQPYLGERFLGDGKTASVRSAKGERPLHTRRNEALGNAIL
ATTDPRLFAQGEEAERFRTIEGQVKMSRYGTDCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGLVTSWDGGPAT
GGGRIVAAGDRRLHEAALKVLNP

Sequences:

>Translated_263_residues
MSVVDLAQFMEDLATQSGAAILPFFRAHFGLDDKSHGTGHAFDPVTEADRAAEAVMRRMINDRLPNHGILGEEFGSERAD
AECVWVLDPIDGTRAFISGLPTWGTLIGLTHHGAAVRGLMHQPYLGERFLGDGKTASVRSAKGERPLHTRRNEALGNAIL
ATTDPRLFAQGEEAERFRTIEGQVKMSRYGTDCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGLVTSWDGGPAT
GGGRIVAAGDRRLHEAALKVLNP
>Mature_262_residues
SVVDLAQFMEDLATQSGAAILPFFRAHFGLDDKSHGTGHAFDPVTEADRAAEAVMRRMINDRLPNHGILGEEFGSERADA
ECVWVLDPIDGTRAFISGLPTWGTLIGLTHHGAAVRGLMHQPYLGERFLGDGKTASVRSAKGERPLHTRRNEALGNAILA
TTDPRLFAQGEEAERFRTIEGQVKMSRYGTDCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGLVTSWDGGPATG
GGRIVAAGDRRLHEAALKVLNP

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=241, Percent_Identity=29.8755186721992, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1788882, Length=223, Percent_Identity=31.8385650224215, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193202570, Length=222, Percent_Identity=28.3783783783784, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=221, Percent_Identity=28.9592760180996, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=244, Percent_Identity=26.6393442622951, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357957, Length=247, Percent_Identity=25.9109311740891, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664918, Length=254, Percent_Identity=26.7716535433071, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24664922, Length=210, Percent_Identity=30.4761904761905, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357329, Length=243, Percent_Identity=27.1604938271605, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28233; Mature: 28102

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVVDLAQFMEDLATQSGAAILPFFRAHFGLDDKSHGTGHAFDPVTEADRAAEAVMRRMI
CCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NDRLPNHGILGEEFGSERADAECVWVLDPIDGTRAFISGLPTWGTLIGLTHHGAAVRGLM
HHCCCCCCCCCHHHCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHH
HQPYLGERFLGDGKTASVRSAKGERPLHTRRNEALGNAILATTDPRLFAQGEEAERFRTI
CCCCCCCHHCCCCCCCCHHCCCCCCCCHHHHHHHHCCEEEEECCCHHEECCCHHHHHHHH
EGQVKMSRYGTDCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGLVTSWDGGPAT
CCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCC
GGGRIVAAGDRRLHEAALKVLNP
CCCEEEEECCHHHHHHHHHHCCC
>Mature Secondary Structure 
SVVDLAQFMEDLATQSGAAILPFFRAHFGLDDKSHGTGHAFDPVTEADRAAEAVMRRMI
CHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NDRLPNHGILGEEFGSERADAECVWVLDPIDGTRAFISGLPTWGTLIGLTHHGAAVRGLM
HHCCCCCCCCCHHHCCCCCCCEEEEEECCCCCHHHHHHCCCCHHHHHHHHCCCHHHHHHH
HQPYLGERFLGDGKTASVRSAKGERPLHTRRNEALGNAILATTDPRLFAQGEEAERFRTI
CCCCCCCHHCCCCCCCCHHCCCCCCCCHHHHHHHHCCEEEEECCCHHEECCCHHHHHHHH
EGQVKMSRYGTDCYAYCMLAAGQIDLVVEAGLKPYDIVALIPIVEGAGGLVTSWDGGPAT
CCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCCC
GGGRIVAAGDRRLHEAALKVLNP
CCCEEEEECCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]