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The map label for this gene is ahcY

Identifier: 218532774

GI number: 218532774

Start: 5212153

End: 5213559

Strand: Reverse

Name: ahcY

Synonym: Mchl_4897

Alternate gene names: 218532774

Gene position: 5213559-5212153 (Counterclockwise)

Preceding gene: 218532775

Following gene: 218532773

Centisome position: 90.23

GC content: 64.82

Gene sequence:

>1407_bases
ATGGCTGTTGCCAACGATTACATCGTCAAGGACATCGGGCTGGCCGATTACGGCCGCAAGGAAATCTCGATCGCCGAGAC
CGAGATGCCCGGCCTGATGTCGACCCGCGCCGAGTACGGCGCGTCGCAGCCGCTCAAGGGCGCCAAGATCGCCGGCTCGC
TGCACATGACGATCCAGACGGCGGTGCTGATCGAGACCCTGAAGGCGCTCGGCGCCGACATCCGCTGGGTGTCGTGCAAC
ATCTACTCGACCCAGGACCACGCCGCCGCCGCGATCGCCGCCGCCGGCATCCCGGTCTTCGCCGTGAAGGGCGAGACCCT
GACCGAGTACTGGGACTACACCTCGAAGCTGTTCGACTGGCATGACGGCGGAATGCCGAACATGATCCTCGACGACGGCG
GCGACGCCACCATGTTCGTTCACCTCGGCCTGCGCGCCGAGAACGGCGACACCGCCTTCCTCGACAAGCCGGAATCCGAG
GAGGAGGAGGTCTTCTTCGCGCTCCTGAAGAAGAAGCTCGCCGAGAAGCCGAAGGGCTGGTTCGCGGGTCTGGCCGACTC
GATCAAGGGCGTCTCCGAGGAGACCACCACGGGCGTGCACCGCCTCTACAACCTCGCCAAGGAGGGCAAGCTGCTCTTCC
CGGCGATCAACGTGAACGACTCGGTCACCAAGTCGAAGTTCGACAACCTCTACGGCTGCAAGGAGTCGCTGGTCGACGGC
ATCCGCCGCGGCACCGACGTCATGATGGCCGGCAAGGTCGCGATGGTCGCGGGCTTCGGCGACGTGGGCAAGGGCTCGGC
CGCTTCGCTGCGCAACGCCGGTTGCCGCGTGCTCGTCTCCGAGATCGATCCGATCTGCGCCCTGCAGGCGGCGATGGAAG
GCTACGAGGTCGTCACGATGGAAGACGCGGCGCCCCGCGCCGACATCTTCGTGACCGCCACGGGCAACAAGGACATCATC
ACGATCGAACACATGCGGGCCATGAAGGACCGTGCGATCGTCTGCAACATCGGCCACTTCGACAACGAGATTCAGGTCGC
CGGCCTGAAGAACCTCAAGTGGCAGAACATCAAGCCGCAGGTCGATGAGATCGAGTTCGCCGACGGCCACCGCATCATCC
TCCTCTCGGAGGGCCGCCTGGTGAACCTCGGCAACGCGACGGGCCACCCGTCCTTCGTGATGTCGGCCTCCTTCACCAAC
CAGACGCTCGCCCAGATCGAGCTCTGGACCAACCCCGGCAAGTACGAGCGTCAGGTCTACACCCTGCCCAAGGCCCTCGA
TGAGAAGGTCGCGGCGCTCCACCTCGAGAAGATCGGCGTGAAGCTCTCCAAGCTCCGCCCCGATCAGGCCGCCTATATCG
GCGTGTCGCAGACCGGCCCGTTCAAGCCCGAGCATTACCGCTACTAA

Upstream 100 bases:

>100_bases
AGCCCTGCTACAGGGATGGCCGACCCGGCCGGGTGAACCGGCCGATGCGCCGGAACGATTGGCCGTTTCGCGCCGGCCAC
GACTGAAAAGGGATACCGAG

Downstream 100 bases:

>100_bases
TCGGTCGTCGGGCCTCCGGCTTCCGCGCAGGAAGTCGGAGGCCCGGTGCCGCTCCGCTCAAGATTCGCGAGGAAGCCCGG
CCGATGGCCGGGCTTCTTTG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MAVANDYIVKDIGLADYGRKEISIAETEMPGLMSTRAEYGASQPLKGAKIAGSLHMTIQTAVLIETLKALGADIRWVSCN
IYSTQDHAAAAIAAAGIPVFAVKGETLTEYWDYTSKLFDWHDGGMPNMILDDGGDATMFVHLGLRAENGDTAFLDKPESE
EEEVFFALLKKKLAEKPKGWFAGLADSIKGVSEETTTGVHRLYNLAKEGKLLFPAINVNDSVTKSKFDNLYGCKESLVDG
IRRGTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVLVSEIDPICALQAAMEGYEVVTMEDAAPRADIFVTATGNKDII
TIEHMRAMKDRAIVCNIGHFDNEIQVAGLKNLKWQNIKPQVDEIEFADGHRIILLSEGRLVNLGNATGHPSFVMSASFTN
QTLAQIELWTNPGKYERQVYTLPKALDEKVAALHLEKIGVKLSKLRPDQAAYIGVSQTGPFKPEHYRY

Sequences:

>Translated_468_residues
MAVANDYIVKDIGLADYGRKEISIAETEMPGLMSTRAEYGASQPLKGAKIAGSLHMTIQTAVLIETLKALGADIRWVSCN
IYSTQDHAAAAIAAAGIPVFAVKGETLTEYWDYTSKLFDWHDGGMPNMILDDGGDATMFVHLGLRAENGDTAFLDKPESE
EEEVFFALLKKKLAEKPKGWFAGLADSIKGVSEETTTGVHRLYNLAKEGKLLFPAINVNDSVTKSKFDNLYGCKESLVDG
IRRGTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVLVSEIDPICALQAAMEGYEVVTMEDAAPRADIFVTATGNKDII
TIEHMRAMKDRAIVCNIGHFDNEIQVAGLKNLKWQNIKPQVDEIEFADGHRIILLSEGRLVNLGNATGHPSFVMSASFTN
QTLAQIELWTNPGKYERQVYTLPKALDEKVAALHLEKIGVKLSKLRPDQAAYIGVSQTGPFKPEHYRY
>Mature_467_residues
AVANDYIVKDIGLADYGRKEISIAETEMPGLMSTRAEYGASQPLKGAKIAGSLHMTIQTAVLIETLKALGADIRWVSCNI
YSTQDHAAAAIAAAGIPVFAVKGETLTEYWDYTSKLFDWHDGGMPNMILDDGGDATMFVHLGLRAENGDTAFLDKPESEE
EEVFFALLKKKLAEKPKGWFAGLADSIKGVSEETTTGVHRLYNLAKEGKLLFPAINVNDSVTKSKFDNLYGCKESLVDGI
RRGTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVLVSEIDPICALQAAMEGYEVVTMEDAAPRADIFVTATGNKDIIT
IEHMRAMKDRAIVCNIGHFDNEIQVAGLKNLKWQNIKPQVDEIEFADGHRIILLSEGRLVNLGNATGHPSFVMSASFTNQ
TLAQIELWTNPGKYERQVYTLPKALDEKVAALHLEKIGVKLSKLRPDQAAYIGVSQTGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=464, Percent_Identity=59.4827586206897, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=59.2760180995475, Blast_Score=489, Evalue=1e-138,
Organism=Homo sapiens, GI298286489, Length=468, Percent_Identity=47.8632478632479, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI195539349, Length=468, Percent_Identity=47.8632478632479, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI24308043, Length=468, Percent_Identity=47.8632478632479, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI195539337, Length=468, Percent_Identity=47.8632478632479, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI21361647, Length=468, Percent_Identity=47.4358974358974, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=60.1713062098501, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320882, Length=484, Percent_Identity=58.6776859504132, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24642172, Length=464, Percent_Identity=61.8534482758621, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24656245, Length=472, Percent_Identity=48.5169491525424, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553387, Length=465, Percent_Identity=48.6021505376344, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553385, Length=464, Percent_Identity=48.4913793103448, Blast_Score=422, Evalue=1e-118,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_METC4 (B7KSJ4)

Other databases:

- EMBL:   CP001298
- RefSeq:   YP_002423590.1
- ProteinModelPortal:   B7KSJ4
- SMR:   B7KSJ4
- GeneID:   7114318
- GenomeReviews:   CP001298_GR
- KEGG:   mch:Mchl_4897
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 51025; Mature: 50894

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 57-57 BINDING 132-132 BINDING 194-194 BINDING 224-224 BINDING 228-228 BINDING 229-229 BINDING 281-281 BINDING 316-316 BINDING 382-382

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVANDYIVKDIGLADYGRKEISIAETEMPGLMSTRAEYGASQPLKGAKIAGSLHMTIQT
CCCCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCEEECEEEEHHHH
AVLIETLKALGADIRWVSCNIYSTQDHAAAAIAAAGIPVFAVKGETLTEYWDYTSKLFDW
HHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCC
HDGGMPNMILDDGGDATMFVHLGLRAENGDTAFLDKPESEEEEVFFALLKKKLAEKPKGW
CCCCCCCEEEECCCCEEEEEEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCH
FAGLADSIKGVSEETTTGVHRLYNLAKEGKLLFPAINVNDSVTKSKFDNLYGCKESLVDG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHH
IRRGTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVLVSEIDPICALQAAMEGYEVVTM
HHCCCCEEEECCEEEEECCCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHCCCEEEEE
EDAAPRADIFVTATGNKDIITIEHMRAMKDRAIVCNIGHFDNEIQVAGLKNLKWQNIKPQ
CCCCCCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCC
VDEIEFADGHRIILLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELWTNPGKYERQVY
CCCEEECCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCEEE
TLPKALDEKVAALHLEKIGVKLSKLRPDQAAYIGVSQTGPFKPEHYRY
ECHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
AVANDYIVKDIGLADYGRKEISIAETEMPGLMSTRAEYGASQPLKGAKIAGSLHMTIQT
CCCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCEEECEEEEHHHH
AVLIETLKALGADIRWVSCNIYSTQDHAAAAIAAAGIPVFAVKGETLTEYWDYTSKLFDW
HHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCC
HDGGMPNMILDDGGDATMFVHLGLRAENGDTAFLDKPESEEEEVFFALLKKKLAEKPKGW
CCCCCCCEEEECCCCEEEEEEEEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCH
FAGLADSIKGVSEETTTGVHRLYNLAKEGKLLFPAINVNDSVTKSKFDNLYGCKESLVDG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHH
IRRGTDVMMAGKVAMVAGFGDVGKGSAASLRNAGCRVLVSEIDPICALQAAMEGYEVVTM
HHCCCCEEEECCEEEEECCCCCCCCCHHHHHCCCCEEEEECCCHHHHHHHHHCCCEEEEE
EDAAPRADIFVTATGNKDIITIEHMRAMKDRAIVCNIGHFDNEIQVAGLKNLKWQNIKPQ
CCCCCCCCEEEEECCCCCEEEHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCC
VDEIEFADGHRIILLSEGRLVNLGNATGHPSFVMSASFTNQTLAQIELWTNPGKYERQVY
CCCEEECCCCEEEEEECCCEEEECCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCCEEE
TLPKALDEKVAALHLEKIGVKLSKLRPDQAAYIGVSQTGPFKPEHYRY
ECHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA