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The map label for this gene is oxlT [H]

Identifier: 218532677

GI number: 218532677

Start: 5084312

End: 5085625

Strand: Reverse

Name: oxlT [H]

Synonym: Mchl_4793

Alternate gene names: 218532677

Gene position: 5085625-5084312 (Counterclockwise)

Preceding gene: 218532678

Following gene: 218532676

Centisome position: 88.02

GC content: 61.57

Gene sequence:

>1314_bases
ATGACCGCCCATGTGCCAGTCAGCCACGACACGGCCATCGCCAGTTCCATGTTGGACAAAGCCGATCGCCCGCCCTTGGG
AAGGTGGGGACAACTCTTCCTCGGCGTCCTCTGCATGTCGATGATCGCCAACCTGCAGTATGGCTGGACGCTCTTCGTCG
ACCCGATCCAGCAGAAGTTCGGTTGGGACCGCACGGCGATCCAGTGGGCTTTCACGATCTTCGTCCTGACTGAGACGTGG
CTCGTTCCAATCGAGGGCTGGTTCGTGGATCGCTACGGCCCGCGGATTGTCACCGTGTTCGGTGGCATCCTTTGCGGGAT
CGGCTGGGTGATGAACTCCTACGCGGACTCGCTCTGGCTCCTCTACGTCGCCGCTGCCATCAGTGGCATCGGCGCGGGCG
CGGTCTACGGCACCTGCGTTGGCAACGCTTTGAAGTGGTTCCCTGACCGGCGCGGGTTCGCGGCCGGCCTCACGGCCGCC
GGGTTCGGTGCCGGTTCGGCGCTGACCGTCATCCCGATCGCCTACATGATCAAGGAGAGCGGCTATCAGCACACCTTCCT
GGTGTTCGGCATTGGCCAAGGCGTTATCGTAGTTCTCGCCGCGCTCCTCCTCGTCGCACCCCGGGCAGGCTTCAAGGACC
GGATGTTGGCAGGTAAGCCCGTCGTGAATACGACATCTCGGCAGCAATACTCGCCCCGTGTGATGGTACGGACGCCGGTG
TTCTGGGTGCTCTATTTCATGTTTATCATGATGGCGGGTGGCGGCCTGATGGCGGCCGCCTCGCTTGCACCCATTGCCAA
GGATTTCAACGTCGCCGGCGTGCCGGTGTCGCTCTTGGGGCTGACCCTGCCGGCCTTGACCTTCGCGCTGACGATCGACC
GCGTCTTGAACGGTGTGACCCGGCCGTTCTTCGGATGGGTCTCCGACCACATCGGTCGTGAGAATACAATGATTATCGCT
TTCCTAATCGAGGGTGTGGGTATCCTTGCGCTCGGCATGTTTGCGCATATCCCGATGGCCTTCGTTCTTCTGACGGGCCT
AGTTTTCTTCGCCTGGGGCGAGATCTACTCGCTGTTTCCGGCGACCTGCACGGACACGTTCGGAGACCAGAACGCGGCCG
CAAATGCAGGGCTTCTCTACACTGCGAAGGGCACCTCGGCGCTTCTGCTCCCGGTCCTCCTGTCCATCCAGGCCTATGCC
GGAAACTGGCAGATCGTCTTCTATCTTGCCTCAGGCATGGCCTTCACATCAGCCTTCCTCGCCATGTTCGTGCTGAAACC
CATGCGTGCGCGGTTCATCGCCCGAAGCATGTGA

Upstream 100 bases:

>100_bases
GGTCAAACGTGTTGCCTTCAGCGAGACTCTGGCATTAGGTATGTGGCATACCAACAAGCCAGAAGCCGCGAAGCGGCCGC
AAGACGTGAGGAGGACGCCA

Downstream 100 bases:

>100_bases
CCCCAAGGAAGCTGCCGGTATTGGCAATCAAGGATCAGGCGAGCGGCCAGCTGCTCGCCTATCGCTGAGGAAGTTCGCCG
GCCTCGCGCCAGAGGATAGG

Product: major facilitator superfamily MFS_1

Products: NA

Alternate protein names: OFA; Oxalate:formate antiport protein; Oxalate:formate exchange protein [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTAHVPVSHDTAIASSMLDKADRPPLGRWGQLFLGVLCMSMIANLQYGWTLFVDPIQQKFGWDRTAIQWAFTIFVLTETW
LVPIEGWFVDRYGPRIVTVFGGILCGIGWVMNSYADSLWLLYVAAAISGIGAGAVYGTCVGNALKWFPDRRGFAAGLTAA
GFGAGSALTVIPIAYMIKESGYQHTFLVFGIGQGVIVVLAALLLVAPRAGFKDRMLAGKPVVNTTSRQQYSPRVMVRTPV
FWVLYFMFIMMAGGGLMAAASLAPIAKDFNVAGVPVSLLGLTLPALTFALTIDRVLNGVTRPFFGWVSDHIGRENTMIIA
FLIEGVGILALGMFAHIPMAFVLLTGLVFFAWGEIYSLFPATCTDTFGDQNAAANAGLLYTAKGTSALLLPVLLSIQAYA
GNWQIVFYLASGMAFTSAFLAMFVLKPMRARFIARSM

Sequences:

>Translated_437_residues
MTAHVPVSHDTAIASSMLDKADRPPLGRWGQLFLGVLCMSMIANLQYGWTLFVDPIQQKFGWDRTAIQWAFTIFVLTETW
LVPIEGWFVDRYGPRIVTVFGGILCGIGWVMNSYADSLWLLYVAAAISGIGAGAVYGTCVGNALKWFPDRRGFAAGLTAA
GFGAGSALTVIPIAYMIKESGYQHTFLVFGIGQGVIVVLAALLLVAPRAGFKDRMLAGKPVVNTTSRQQYSPRVMVRTPV
FWVLYFMFIMMAGGGLMAAASLAPIAKDFNVAGVPVSLLGLTLPALTFALTIDRVLNGVTRPFFGWVSDHIGRENTMIIA
FLIEGVGILALGMFAHIPMAFVLLTGLVFFAWGEIYSLFPATCTDTFGDQNAAANAGLLYTAKGTSALLLPVLLSIQAYA
GNWQIVFYLASGMAFTSAFLAMFVLKPMRARFIARSM
>Mature_436_residues
TAHVPVSHDTAIASSMLDKADRPPLGRWGQLFLGVLCMSMIANLQYGWTLFVDPIQQKFGWDRTAIQWAFTIFVLTETWL
VPIEGWFVDRYGPRIVTVFGGILCGIGWVMNSYADSLWLLYVAAAISGIGAGAVYGTCVGNALKWFPDRRGFAAGLTAAG
FGAGSALTVIPIAYMIKESGYQHTFLVFGIGQGVIVVLAALLLVAPRAGFKDRMLAGKPVVNTTSRQQYSPRVMVRTPVF
WVLYFMFIMMAGGGLMAAASLAPIAKDFNVAGVPVSLLGLTLPALTFALTIDRVLNGVTRPFFGWVSDHIGRENTMIIAF
LIEGVGILALGMFAHIPMAFVLLTGLVFFAWGEIYSLFPATCTDTFGDQNAAANAGLLYTAKGTSALLLPVLLSIQAYAG
NWQIVFYLASGMAFTSAFLAMFVLKPMRARFIARSM

Specific function: Anion transporter that carries out the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation, at the plasma membrane, and in doing so catalyzes the vectorial portion of a proton-motive metabolic cycle that drives ATP

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. OFA (TC 2.A.1.11) family [H]

Homologues:

Organism=Escherichia coli, GI1789969, Length=366, Percent_Identity=26.775956284153, Blast_Score=116, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281360217, Length=186, Percent_Identity=30.1075268817204, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573971, Length=186, Percent_Identity=30.1075268817204, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004741 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47275; Mature: 47144

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHVPVSHDTAIASSMLDKADRPPLGRWGQLFLGVLCMSMIANLQYGWTLFVDPIQQKF
CCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHC
GWDRTAIQWAFTIFVLTETWLVPIEGWFVDRYGPRIVTVFGGILCGIGWVMNSYADSLWL
CCCHHHHHHHHHHHHHHHHHEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYVAAAISGIGAGAVYGTCVGNALKWFPDRRGFAAGLTAAGFGAGSALTVIPIAYMIKES
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCC
GYQHTFLVFGIGQGVIVVLAALLLVAPRAGFKDRMLAGKPVVNTTSRQQYSPRVMVRTPV
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCH
FWVLYFMFIMMAGGGLMAAASLAPIAKDFNVAGVPVSLLGLTLPALTFALTIDRVLNGVT
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RPFFGWVSDHIGRENTMIIAFLIEGVGILALGMFAHIPMAFVLLTGLVFFAWGEIYSLFP
HHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ATCTDTFGDQNAAANAGLLYTAKGTSALLLPVLLSIQAYAGNWQIVFYLASGMAFTSAFL
CHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHH
AMFVLKPMRARFIARSM
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TAHVPVSHDTAIASSMLDKADRPPLGRWGQLFLGVLCMSMIANLQYGWTLFVDPIQQKF
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHC
GWDRTAIQWAFTIFVLTETWLVPIEGWFVDRYGPRIVTVFGGILCGIGWVMNSYADSLWL
CCCHHHHHHHHHHHHHHHHHEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LYVAAAISGIGAGAVYGTCVGNALKWFPDRRGFAAGLTAAGFGAGSALTVIPIAYMIKES
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHCC
GYQHTFLVFGIGQGVIVVLAALLLVAPRAGFKDRMLAGKPVVNTTSRQQYSPRVMVRTPV
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCH
FWVLYFMFIMMAGGGLMAAASLAPIAKDFNVAGVPVSLLGLTLPALTFALTIDRVLNGVT
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RPFFGWVSDHIGRENTMIIAFLIEGVGILALGMFAHIPMAFVLLTGLVFFAWGEIYSLFP
HHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ATCTDTFGDQNAAANAGLLYTAKGTSALLLPVLLSIQAYAGNWQIVFYLASGMAFTSAFL
CHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHH
AMFVLKPMRARFIARSM
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8636101; 9651403; 11919184; 11113128; 11274108; 11500368 [H]