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The map label for this gene is pncB [H]

Identifier: 218232668

GI number: 218232668

Start: 620534

End: 621997

Strand: Reverse

Name: pncB [H]

Synonym: BCB4264_A0635

Alternate gene names: 218232668

Gene position: 621997-620534 (Counterclockwise)

Preceding gene: 218236021

Following gene: 218231004

Centisome position: 11.48

GC content: 36.82

Gene sequence:

>1464_bases
ATGACTCATTATAAAGACGATAGTTATGCCTTACATACAGACCTATATCAAATCAACATGGCTTATACATATTGGAAAGA
TGGTATTCATAATCGCCGTTCTGTTTTTGATTTATATTTTCGAAAGCTTCCATTTGAGAACGGCTACGCTGTTTTTGCTG
GCCTTGAGAAAATTGTAGAGTACATAGAAAATTTCAGTTTTACTGAAAGCGATATCGCTTATTTAGCAGAATTACAATTT
GAAGAAGAATTCCTTCATTATTTACAAAATATGAAATTCACTGGGACGATTCGCAGTATGCAAGAAGGTGAAGTTGTATT
TAATAACGAGCCTTTATTACGTGTTGATGCACCACTTGGTGAAGCACAAATTATTGAGACTGCCCTCTTAAATATTGTGA
ATTACCAAACATTAATTGCCACAAAAGCAGCACGTATGAAACATGCTGCAAGTAATGATGAGCTTTTAGAGTTCGGCACA
AGACGTGCCCATGAGTTCGATGCTGCCCTTTGGGGGACGCGTGCTGCCTTTATTGGTGGTTTCTCCTCTACAAGCAACGT
TCGTGCTGGGAAACGCTTTGGGATTCCTGTAGCTGGCACACACGCTCACTCTTTCGTTCAAGCATATCGCGATGAATACG
TCGCGTTTAAAAAATACGCTGAAACTCATAAAAAGTGCGTCTTTCTCGTTGATACATATGACACATTGAAATCTGGTGTT
CCAAATGCGATTCGTGTTGCAAAAGAATTTGGGGATCGTATTGATTTCTATGGCATACGTCTTGATAGTGGTGATATGGC
TTATTTATCGAAAAAGGCACGAAAACTATTAGATGAAGCAGGGTTTACAAATACAAAAATTATCGCTTCTAGCGATTTAG
ATGAATACACAATTATGCACCTTAAATCTCAAGGAGCAAAAATTGACGTATGGGGCGTTGGGACAAAATTAATTACGTCC
TTTGAGCAACCTGCATTGGGGGCTGTTTACAAACTAGTTGCGATTGAAGATACTGACGGAAAATTAAATGATACGATTAA
AATTTCATCTAACCCTGAAAAAATTACCACTCCAGGACTGAAACGAATTTATCGTATTATCAATCGGGTAAACGATCATG
CAGAAGGCGATTATATTGCGTTAGATTCTGAAGAACCTGGAAAAGAAGAGCGCTTAAAAATGTTCCATCCAGTTCACACA
TATATAAGTAAATTCGTAACAAACTTTGAAGCCCGTGAACTGCATAAAGATATTTTCGTTAACGGTGAAAGAACATATGA
ACTACCAAGTATATTAGATATTCAAAAATATAATGAACAGAGTCTCTCTCTATTTTGGGAAGAATATATGCGAACTTTAA
ATCCTGAAGAATACCCTGTCGATTTAAGCCAAGAGTGTTGGGATCATAAAATGAATTACATTCAAACAGTTCGAGAACAA
GTTGAAAAAAACATACAAAAGTAA

Upstream 100 bases:

>100_bases
TTTCATTTTTTTCTCTCTTGACTTCACATCAATATCTCTTCTTTGCTACGAATGGTGAAAAATTGGTATACTATAACCAA
ATTATGGAGGTGTTCTCGCG

Downstream 100 bases:

>100_bases
ACAGAGAAGTTTCCCTTCTCTGTTTTTTCAATACTATATGGATATTTGTAAAAAATATATTAAAATAATAAGACGAGTGT
ATTTTATTTGTAAATTTTAA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MTHYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQF
EEEFLHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGT
RRAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGV
PNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITS
FEQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGLKRIYRIINRVNDHAEGDYIALDSEEPGKEERLKMFHPVHT
YISKFVTNFEARELHKDIFVNGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQ
VEKNIQK

Sequences:

>Translated_487_residues
MTHYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQF
EEEFLHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGT
RRAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGV
PNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITS
FEQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGLKRIYRIINRVNDHAEGDYIALDSEEPGKEERLKMFHPVHT
YISKFVTNFEARELHKDIFVNGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQ
VEKNIQK
>Mature_486_residues
THYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVEYIENFSFTESDIAYLAELQFE
EEFLHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLGEAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTR
RAHEFDAALWGTRAAFIGGFSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGVP
NAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMHLKSQGAKIDVWGVGTKLITSF
EQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGLKRIYRIINRVNDHAEGDYIALDSEEPGKEERLKMFHPVHTY
ISKFVTNFEARELHKDIFVNGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQV
EKNIQK

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=515, Percent_Identity=31.0679611650485, Blast_Score=249, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI71997947, Length=519, Percent_Identity=37.3795761078998, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI71997952, Length=519, Percent_Identity=37.3795761078998, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI71997955, Length=206, Percent_Identity=48.0582524271845, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24581587, Length=519, Percent_Identity=35.4527938342967, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI161076680, Length=204, Percent_Identity=44.1176470588235, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24581595, Length=204, Percent_Identity=44.1176470588235, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI28574709, Length=204, Percent_Identity=44.1176470588235, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24581593, Length=204, Percent_Identity=44.1176470588235, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24581591, Length=204, Percent_Identity=44.1176470588235, Blast_Score=167, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56098; Mature: 55967

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVE
CCCCCCCCEEEEEEEEEEEEEEEEHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YIENFSFTESDIAYLAELQFEEEFLHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCCCEEECCCCEEEEECCCC
EAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAHEFDAALWGTRAAFIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC
FSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHCC
PNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMH
CHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHEEEE
LKSQGAKIDVWGVGTKLITSFEQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGL
EECCCCEEEEEECCHHHHHHCCCCHHHHEEEEEEEECCCCCCCCEEEECCCCCCCCCHHH
KRIYRIINRVNDHAEGDYIALDSEEPGKEERLKMFHPVHTYISKFVTNFEARELHKDIFV
HHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHEE
NGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQ
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VEKNIQK
HHHHCCC
>Mature Secondary Structure 
THYKDDSYALHTDLYQINMAYTYWKDGIHNRRSVFDLYFRKLPFENGYAVFAGLEKIVE
CCCCCCCEEEEEEEEEEEEEEEEHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YIENFSFTESDIAYLAELQFEEEFLHYLQNMKFTGTIRSMQEGEVVFNNEPLLRVDAPLG
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCCCEEECCCCEEEEECCCC
EAQIIETALLNIVNYQTLIATKAARMKHAASNDELLEFGTRRAHEFDAALWGTRAAFIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCC
FSSTSNVRAGKRFGIPVAGTHAHSFVQAYRDEYVAFKKYAETHKKCVFLVDTYDTLKSGV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHCC
PNAIRVAKEFGDRIDFYGIRLDSGDMAYLSKKARKLLDEAGFTNTKIIASSDLDEYTIMH
CHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHEEEE
LKSQGAKIDVWGVGTKLITSFEQPALGAVYKLVAIEDTDGKLNDTIKISSNPEKITTPGL
EECCCCEEEEEECCHHHHHHCCCCHHHHEEEEEEEECCCCCCCCEEEECCCCCCCCCHHH
KRIYRIINRVNDHAEGDYIALDSEEPGKEERLKMFHPVHTYISKFVTNFEARELHKDIFV
HHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHEE
NGERTYELPSILDIQKYNEQSLSLFWEEYMRTLNPEEYPVDLSQECWDHKMNYIQTVREQ
CCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VEKNIQK
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]