Click here to switch to the map view.

The map label for this gene is fhuB [H]

Identifier: 218231978

GI number: 218231978

Start: 374310

End: 375350

Strand: Reverse

Name: fhuB [H]

Synonym: BCB4264_A0397

Alternate gene names: 218231978

Gene position: 375350-374310 (Counterclockwise)

Preceding gene: 218235274

Following gene: 218233793

Centisome position: 6.93

GC content: 38.62

Gene sequence:

>1041_bases
ATGAACAGAAAAGATGTGAAACGAATGACAAAAGATCACGACAATCCACGTTCTATAGCTTTTACATACAAACTAATTTT
AAGCTTAATTGCATTCTTTCTTATTTTTATGGTTGCAATGGTATTAGGTGCTGCAGATACTTCGATAAAAGATGTATGGT
TAGCACTCACTTCCTCCGCTAAAGGAGACAAAATATCTATTATTCGAGAAATACGTTTACCACGTGAAGTTGCTGCTATT
TTTGTAGGAGCTGGATTAGCCGTTTCTGGGGCAATTATGCAAGGATTAACACGAAATCCACTTGCGGATCCTGGATTATT
AGGGCTATCTGGTGGAGCAAATGCTGCGCTTGCACTGACACTTGCTTTCAACCCTTCCATCAGCTATCTTTACTTAACAT
TAGCTTGCTTTATCGGTGCGGCAATTGGCGCAATTATGGTATTTGGAATTGGTATGGTGAAAAAAGGCGGCCTTTCTCCT
CTTCGAATTGTATTAGCAGGCGCTGCAGTTTCAGCATTTCTACTCGCAATTTCAGAAGGAATCGGCATTTACTTTAAAAT
TTCACAAGATGTATCACTTTGGACTGCTGGGGGCGTAATTGGAACAACTTGGAGCCAATTAAAAATTATTATTCCAGTCA
TTTCAATTAGTATCTTTATCGCTATCTTACTAGCAAAAAAATTGACAGTTCTTAGTTTCAGTGAGGAAGTGGCTATTGGA
CTAGGTCAAAAAATTATTGTTATTAAAACTATTTTATTTATCATTATTATCTTACTTGCAGGTGCATCTGTAGCGCTTGT
TGGAAATATGGCATTTATCGGCTTAATGGTACCTCACATGGTACGCCCAATTGTCGGTCCAGATTACCGATTTGTTATAC
CGATGTCAGCAATTGCTGGAGCTTCCTTTATGCTACTTGCAGATACAATCGGACGTACTATTAACGCTCCATACGAAACA
CCAGTTGCGGCAATTGTTGCGATTGTAGGGTTACCATTCTTCCTATTCATTGTACGTAAAGGAGGAAAAACATTCTCATG
A

Upstream 100 bases:

>100_bases
TACACTAGATTTCCAACTAGACTTCTTCAAGAAGAGCTTTCTTGGTAAATAATACAAACATGAGGAATTCTTAAATTAAG
AATTCCTCTTCCTTTATTCT

Downstream 100 bases:

>100_bases
TGCAATCTATTTTAAGAAAACAGCGTCTCATTATACTCGCTTTACTTATAGTAATCATCACAACCATTGTAGTTGGAATG
GGACTTGGTTCAGCGTCTTT

Product: iron compound ABC transporter, permease protein

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MNRKDVKRMTKDHDNPRSIAFTYKLILSLIAFFLIFMVAMVLGAADTSIKDVWLALTSSAKGDKISIIREIRLPREVAAI
FVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALTLAFNPSISYLYLTLACFIGAAIGAIMVFGIGMVKKGGLSP
LRIVLAGAAVSAFLLAISEGIGIYFKISQDVSLWTAGGVIGTTWSQLKIIIPVISISIFIAILLAKKLTVLSFSEEVAIG
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAGASFMLLADTIGRTINAPYET
PVAAIVAIVGLPFFLFIVRKGGKTFS

Sequences:

>Translated_346_residues
MNRKDVKRMTKDHDNPRSIAFTYKLILSLIAFFLIFMVAMVLGAADTSIKDVWLALTSSAKGDKISIIREIRLPREVAAI
FVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALTLAFNPSISYLYLTLACFIGAAIGAIMVFGIGMVKKGGLSP
LRIVLAGAAVSAFLLAISEGIGIYFKISQDVSLWTAGGVIGTTWSQLKIIIPVISISIFIAILLAKKLTVLSFSEEVAIG
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAGASFMLLADTIGRTINAPYET
PVAAIVAIVGLPFFLFIVRKGGKTFS
>Mature_346_residues
MNRKDVKRMTKDHDNPRSIAFTYKLILSLIAFFLIFMVAMVLGAADTSIKDVWLALTSSAKGDKISIIREIRLPREVAAI
FVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALTLAFNPSISYLYLTLACFIGAAIGAIMVFGIGMVKKGGLSP
LRIVLAGAAVSAFLLAISEGIGIYFKISQDVSLWTAGGVIGTTWSQLKIIIPVISISIFIAILLAKKLTVLSFSEEVAIG
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAGASFMLLADTIGRTINAPYET
PVAAIVAIVGLPFFLFIVRKGGKTFS

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=304, Percent_Identity=36.1842105263158, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1790741, Length=282, Percent_Identity=34.7517730496454, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790740, Length=295, Percent_Identity=33.8983050847458, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788004, Length=280, Percent_Identity=35.3571428571429, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786347, Length=292, Percent_Identity=29.7945205479452, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786804, Length=305, Percent_Identity=27.8688524590164, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36496; Mature: 36496

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKDVKRMTKDHDNPRSIAFTYKLILSLIAFFLIFMVAMVLGAADTSIKDVWLALTSSA
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
KGDKISIIREIRLPREVAAIFVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALT
CCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEEE
LAFNPSISYLYLTLACFIGAAIGAIMVFGIGMVKKGGLSPLRIVLAGAAVSAFLLAISEG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
IGIYFKISQDVSLWTAGGVIGTTWSQLKIIIPVISISIFIAILLAKKLTVLSFSEEVAIG
CEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAG
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
ASFMLLADTIGRTINAPYETPVAAIVAIVGLPFFLFIVRKGGKTFS
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNRKDVKRMTKDHDNPRSIAFTYKLILSLIAFFLIFMVAMVLGAADTSIKDVWLALTSSA
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
KGDKISIIREIRLPREVAAIFVGAGLAVSGAIMQGLTRNPLADPGLLGLSGGANAALALT
CCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCEEEEEE
LAFNPSISYLYLTLACFIGAAIGAIMVFGIGMVKKGGLSPLRIVLAGAAVSAFLLAISEG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
IGIYFKISQDVSLWTAGGVIGTTWSQLKIIIPVISISIFIAILLAKKLTVLSFSEEVAIG
CEEEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHC
LGQKIIVIKTILFIIIILLAGASVALVGNMAFIGLMVPHMVRPIVGPDYRFVIPMSAIAG
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHCC
ASFMLLADTIGRTINAPYETPVAAIVAIVGLPFFLFIVRKGGKTFS
CHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]