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The map label for this gene is hemL1 [H]

Identifier: 218231071

GI number: 218231071

Start: 519721

End: 521019

Strand: Reverse

Name: hemL1 [H]

Synonym: BCB4264_A0536

Alternate gene names: 218231071

Gene position: 521019-519721 (Counterclockwise)

Preceding gene: 218233302

Following gene: 218231636

Centisome position: 9.61

GC content: 40.72

Gene sequence:

>1299_bases
GTGAATTTCACAAAGTCAGAAGCATTACATAAAGAAGCTTTAGAGCATATCGTTGGCGGTGTTAACAGTCCTTCTCGTTC
TTTTAAAGCAGTTGGCGGCGGCGCTCCTGTTGCTATGGAACGTGGGAAAGGCGCTTATTTCTGGGATGTAGACGGAAATA
AATATATCGATTATTTAGCAGCATACGGTCCTATTATTACTGGACATGCTCATCCGCATATAACAAAAGCAATTACAACA
GCTGCTGAAAATGGGGTACTTTATGGAACACCAACAGCGCTAGAGGTAAAATTCGCAAAAATGTTAAAAGAAGCAATGCC
TGCATTAGATAAAGTCCGTTTCGTAAACTCTGGTACAGAAGCAGTGATGACAACGATTCGTGTTGCTCGTGCTTATACAG
GTCGCACAAAAATCATGAAATTTGCTGGTTGTTACCACGGTCATTCTGATTTAGTACTTGTGGCAGCTGGATCTGGCCCT
TCTACTTTAGGAACTCCTGATTCAGCTGGCGTACCACAAAGTATCGCACAAGAAGTTATTACCGTTCCATTTAACAATGT
AGAAACTTTAAAAGAAGCTTTAGATAAATGGGGTCATGAAGTAGCAGCTATCCTTGTAGAACCGATCGTTGGAAACTTCG
GTATTGTAGAGCCTAAACCTGGATTCCTTGAAAAAGTGAATGAACTTGTTCACGAAGCTGGCGCACTAGTAATTTATGAT
GAAGTTATTACTGCTTTCCGCTTTATGTACGGCGGTGCTCAAGACTTACTTGGTGTTACACCTGACTTAACAGCGCTTGG
TAAAGTTATTGGCGGTGGCTTACCAATCGGTGCTTACGGTGGTAAGAAAGAAATTATGGAACAAGTTGCTCCGCTTGGAC
CTGCATACCAAGCTGGTACAATGGCAGGAAACCCTGCTTCTATGGCATCAGGTATCGCTTGTCTAGAAGTACTTCAACAA
GAAGGGCTTTATGAGAAATTAGATGAACTTGGTGCAATGCTTGAAAAAGGAATTTTAGAGCAAGCAGCGAAACATAATAT
CGACATTACATTAAATCGTCTAAAAGGGGCTTTAACTGTATACTTCACAACTAATACAATTGAAGATTACGATGCCGCAC
AAGATACAGACGGTGAAATGTTCGGTAAATTCTTCAAGCTTATGCTTCAAGAAGGAGTTAACTTAGCACCTTCTAAATAC
GAGGCATGGTTCTTAACTACAGAACATACAAAAGAAGATATTGAATATACAATTGAAGCTGTCGGCAGAGCATTTGCTGC
CCTAGCAGACAATAAATAA

Upstream 100 bases:

>100_bases
ACGAATAGTTTACCCAACTGCCTTCGCTATCACAAACAATACGTCTTTTCGAAAAACATGTTAGAATAATACATAGATTT
TTGTAAGGAGATGAATTGTA

Downstream 100 bases:

>100_bases
TCCCTTCATTCAAAAGGAAAAAAGAAAGCTCACCTTTCTTTTTTCCTTTTTTCTATTTCATAAATCACGTATTAATAGTA
TAATTATTCATAATTATCTG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1 [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITT
AAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVIYD
EVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQ
EGLYEKLDELGAMLEKGILEQAAKHNIDITLNRLKGALTVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGVNLAPSKY
EAWFLTTEHTKEDIEYTIEAVGRAFAALADNK

Sequences:

>Translated_432_residues
MNFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITT
AAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVIYD
EVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQ
EGLYEKLDELGAMLEKGILEQAAKHNIDITLNRLKGALTVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGVNLAPSKY
EAWFLTTEHTKEDIEYTIEAVGRAFAALADNK
>Mature_432_residues
MNFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLAAYGPIITGHAHPHITKAITT
AAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTEAVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGP
STLGTPDSAGVPQSIAQEVITVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVIYD
EVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQ
EGLYEKLDELGAMLEKGILEQAAKHNIDITLNRLKGALTVYFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGVNLAPSKY
EAWFLTTEHTKEDIEYTIEAVGRAFAALADNK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=350, Percent_Identity=34, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI37574042, Length=346, Percent_Identity=29.1907514450867, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI13994255, Length=337, Percent_Identity=28.1899109792285, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI24119277, Length=331, Percent_Identity=27.4924471299094, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI226442705, Length=345, Percent_Identity=27.2463768115942, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI226442709, Length=305, Percent_Identity=30.1639344262295, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI284507298, Length=268, Percent_Identity=32.8358208955224, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=49.5305164319249, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1789016, Length=338, Percent_Identity=30.4733727810651, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI145693181, Length=444, Percent_Identity=30.6306306306306, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789759, Length=316, Percent_Identity=31.3291139240506, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788044, Length=300, Percent_Identity=31, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1787560, Length=319, Percent_Identity=30.4075235109718, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=316, Percent_Identity=32.9113924050633, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=359, Percent_Identity=29.5264623955432, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=341, Percent_Identity=26.9794721407625, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144274, Length=306, Percent_Identity=30.0653594771242, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=168, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=348, Percent_Identity=30.4597701149425, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6324432, Length=356, Percent_Identity=24.1573033707865, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357415, Length=313, Percent_Identity=33.8658146964856, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI21356575, Length=326, Percent_Identity=28.8343558282209, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI161085790, Length=353, Percent_Identity=28.0453257790368, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574759, Length=353, Percent_Identity=28.0453257790368, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46206; Mature: 46206

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLA
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEECCCCCEEEECCCCHHHHHHH
AYGPIITGHAHPHITKAITTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTE
HHCCEEECCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQEVI
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
TVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVIYD
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEHH
EVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGT
HHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
MAGNPASMASGIACLEVLQQEGLYEKLDELGAMLEKGILEQAAKHNIDITLNRLKGALTV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEE
YFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGVNLAPSKYEAWFLTTEHTKEDIEYTIEA
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VGRAFAALADNK
HHHHHHHHCCCC
>Mature Secondary Structure
MNFTKSEALHKEALEHIVGGVNSPSRSFKAVGGGAPVAMERGKGAYFWDVDGNKYIDYLA
CCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEECCCCCEEEECCCCHHHHHHH
AYGPIITGHAHPHITKAITTAAENGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTE
HHCCEEECCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
AVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQEVI
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHH
TVPFNNVETLKEALDKWGHEVAAILVEPIVGNFGIVEPKPGFLEKVNELVHEAGALVIYD
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEHH
EVITAFRFMYGGAQDLLGVTPDLTALGKVIGGGLPIGAYGGKKEIMEQVAPLGPAYQAGT
HHHHHHHHHHCCHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
MAGNPASMASGIACLEVLQQEGLYEKLDELGAMLEKGILEQAAKHNIDITLNRLKGALTV
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEE
YFTTNTIEDYDAAQDTDGEMFGKFFKLMLQEGVNLAPSKYEAWFLTTEHTKEDIEYTIEA
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHH
VGRAFAALADNK
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA